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Ninety-four female patients with 94 breast lesions underwent B-mode ultrasound and SWE, evaluating elastic modulus standard deviation (ESD) and maximum elasticity (Emax). Results show Emax and ESD correlate with tumor size and are higher with lymph node metastasis and Ki-67 positivity. Combined BIRADS and quantitative parameters show moderate diagnostic efficacy for predicting lymph node metastasis.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/three-dimensional-and-two-dimensional-shear-wave-elastography-associations-of-quantitative-elasticity-values-with-prognostic-factors-of-breast-cancer/417297/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/three-dimensional-and-two-dimensional-shear-wave-elastography-associations-of-quantitative-elasticity-values-with-prognostic-factors-of-breast-cancer/417297.png","ImageObject",300,407,{"name":92,"@type":93},"hdkawk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the aim of this study?","Question",{"text":113,"@type":114},"To assess correlations between 3D and 2D quantitative shear-wave elastography values and prognostic factors in invasive breast cancer.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How many patients and lesions were included?",{"text":118,"@type":114},"Ninety-four female patients with 94 breast lesions were tested using B-mode ultrasound and SWE.",{"name":120,"@type":111,"acceptedAnswer":121},"Which SWE parameters were evaluated and what associations were found?",{"text":122,"@type":114},"Emax and ESD were evaluated. Both showed correlations with tumor size subgroups and lymph node metastasis status, and were higher in Ki-67-positive cancers.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},417297,1790794186,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},3985747859855,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","| Original Article |\n| --- |\n|  |\n\nThree‑dimensional and Two‑dimensional Shear Wave Elastography: Associations of Quantitative Elasticity Values with Prognostic Factors of Breast Cancer  \nJie Tian1, Xin Liu2, Chun Yu Chai2, Jian Qiao Zhou1*  \n1Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2Department of General Surgery, Ruijin Hospital,  \nShanghai Jiao Tong University School of Medicine, Shanghai, China  \nAbstract  \nBackground: The aim of the study was to investigate the correlation of three‑dimensional (3D) and two‑dimensional (2D) quantitative shear‑ wave elastography (SWE) with prognostic factors in invasive breast cancer. Methods: Ninety‑four female patients with 94 breast lesions were tested using B‑mode ultrasound and SWE. 3D and 2D quantitative SWE characteristics, including elastic modulus standard deviation (ESD) and maximum elasticity (Emax), were evaluated. The pathological prognostic indicators for breast cancer were assessed, encompassing factors such as tumor dimensions, histological grade, lymph node involvement, the status of histologic biomarkers, and the classification of tumor subtypes. Associations between 3D and 2D quantitative SWE values and prognostic factors of breast tumors were analyzed. Results: The quantitative parameters Emax and ESD exhibited a notable correlation with tumor size subgroups (3D: P = 0.002 and P = 0.024; 2D: P = 0.003 and P = 0.008), and had a positive correlation with tumor size (3D: Emax P = 0.379, P = 0.0002, ESD P = 0.234, P = 0.023; 2D: Emax P = 0.398, P = 0.000, ESD P = 0.361, P = 0.004) . The Emax and ESD of breast cancer patients exhibiting lymph node metastasis were markedly elevated in comparison to those without lymph node metastasis (3D: P = 0.024 and P = 0.036; 2D: P = 0.031 and P = 0.011) . Emax and ESD except for ESDin 3D SWE were markedly elevated in Ki‑67‑positive breast cancers than in negatively expressed breast cancers (3D: P = 0.033 and P = 0.105; 2D: P = 0.044 and P = 0.029) . Combined BIRADS and 3D and 2D quantitative parameters demonstrated moderate diagnostic efficacy in predicting lymph node metastasis (area under the curve = 0.714) . Conclusion: 3D and 2D quantitative parameters Emax and ESD demonstrate significant associations with prognostic factors in invasive breast cancer, including tumor size, lymph node involvement, and Ki‑67 expression.  \nKeywords: Breast, elastography, prognostic factors, three‑dimensional, ultrasound  \nIntroductIon  \nAccording to the 2024 cancer statistics report, breast cancer is the most prevalent cancer globally among women,[1] characterized by its heterogeneity in clinical, histological, and molecular features that influence prognosis and treatment. [2] The primary prognostic factors for invasive breast tumors are tumor size, histological grade, and lymph node stage. Carcinomas larger than 20 mm, high nuclear grade, and positive lymph node status typically indicate aggressive biological behavior, characterized by high recurrence and low survival rates. [3,4] Biological markers such as estrogen receptors (ER), progesterone receptors (PR), human epidermal growth factor receptor 2 (HER2) and  \nReceived: 01‑12‑2024 Revised: 21‑01‑2025 Accepted: 20‑03‑2025 Available Online: 16‑06‑2025  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code:\u003Cbr>| Website:\u003Cbr>[https://journals.lww.com/jmut](https://journals.lww.com/jmut) |\n|  | DOI:\u003Cbr>10.4103/jmu.JMU‑D‑24‑00023 |\n\nKi‑67 index help anticipate treatment response and patient prognosis. In addition, classifying disease subtypes–luminal A, luminal B, HER2‑enriched, and triple‑negative breast cancer (TNBC)–is crucial. This classification is contingent on fluorescence in situ hybridization (FISH) or immunohistochemical results of ER, PR, HER2, and Ki‑67 expression. [5]  \nUltrasound elastography serves as an important diagnostic instrument for the evaluation of tissue rigidity. Current  \nAddress for correspond","cbCaip5PNnHN270L","https://ap.wps.com/l/cbCaip5PNnHN270L","pdf",2908095,"English","# Background\n# Methods\n# Results\n# Conclusion\n# Keywords","[{\"question\":\"What was the aim of this study?\",\"answer\":\"To assess correlations between 3D and 2D quantitative shear-wave elastography values and prognostic factors in invasive breast cancer.\"},{\"question\":\"How many patients and lesions were included?\",\"answer\":\"Ninety-four female patients with 94 breast lesions were tested using B-mode ultrasound and SWE.\"},{\"question\":\"Which SWE parameters were evaluated and what associations were found?\",\"answer\":\"Emax and ESD were evaluated. Both showed correlations with tumor size subgroups and lymph node metastasis status, and were higher in Ki-67-positive cancers.\"}]","Three-dimensional and Two-dimensional Shear Wave Elastography - Associations of Quantitative Elasticity Values with Prognostic Factors of Breast Cancer | PDF",1790608751,25]