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This open-access case report describes a metachronous triple primary cancer sequence, detailing diagnostic workup, imaging follow-up, and treatment across the three organ 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and Renal in a Single Patient: A Case Report  \nAmir Alinejad Khorram1  | Mohammad Soleimani2  | Ali Amani-Beni1  | Tahmineh Mollasharifi3  | Reza Amani-Beni4  | Farzad Allameh2   \n1Laser Application in Medical Sciences Research Center, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran,  \nIran | 2Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran | 3Department of Pathology, Shahid Modarres Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran | 4School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran  \nCorrespondence: Farzad Allameh ([farzadallame@gmail.com](farzadallame@gmail.com))  \nReceived: 27 April 2024 | Revised: 16 September 2024 | Accepted: 29 January 2025  \nFunding: The authors received no specific funding for this work.  \nKeywords: breast neoplasms | esophageal neoplasms | kidney neoplasms | metachronous | multiple primary cancer  \n\n| ABSTRACT\u003Cbr>There are different combinations of multiple primary cancers; however, the combination of breast, esophagus, and renal cancer has been reported in a few cases. Given the rising prevalence of multiple primary cancers over the past decade, understanding the risk factors for early detection is crucial. |  |\n| --- | --- |\n| 1 | Introduction | left breast in July 2020 (Figure 1) . Under ultrasound guidance, a core needle biopsy was performed, revealing ductal |\n| Patients with cancer may develop multiple cancers during their | carcinoma in situ (DCIS) (Figure 2). Following this diagnosis, |\n| lifetime. When more than one cancer is identified for a patient, | she underwent a left lumpectomy to remove the breast tumor. |\n| it is called multiple primary cancers.“Multiple primary cancers” | The patient underwent 40 courses of radiotherapy until 2021. |\n| means the occurrence of synchronous or metachronous cancer | About 2 years after the lumpectomy, she complained of pro- |\n| in one patient, but it does not include metastases of primary | gressive dysphagia, because of which she underwent an en- |\n| cancer [1] . With the expansion of screening programs and im- | doscopy in August 2022. During the endoscopy, a submucosal |\n| provements in early detection, the incidence of multiple primary | polypoid lesion was observed in the middle third of the esoph- |\n| cancers is increasing worldwide [2]. Also, the increase in cancer | agus (Figure 3), and a biopsy was taken from it. The pathology |\n| survivors due to the progress of treatment measures and side ef- | report was squamous cell carcinoma (SCC) (pT2) . Microscopic |\n| fects of chemotherapy and radiation therapy have been factors | examination images are presented in Figure 4. She also under- |\n| influencing the increase in the occurrence of multiple primary | went an endoscopic ultrasound for the assessment of esoph- |\n| cancers [3] . Herein, we report a rare case of metachronous triple | ageal cancer, which revealed an esophageal SCC located at |\n| primary tumors, including breast, esophagus, and renal cancer. | 24–26 cm from the lower incisors (staging: T2-N0-Mx) . She was started on nonsurgical treatment, including chemotherapy and radiation therapy. |\n| 2 | Case/Examination |  |\n| A 65-year-old woman was first diagnosed with a palpable solid | Afterward, the patient periodically underwent imaging studies for follow-up. About 1 month later, she was incidentally di- |\n| mass measuring approximately 2 × 3.3 cm in diameter in her | agnosed with an enhancing solid lesion in the posteromedial |\n| This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.\u003Cbr>© 2025 The Author(s).","cbCaiq5VHEssjyWr","https://ap.wps.com/l/cbCaiq5VHEssjyWr","pdf",1039589,"English","# Introduction\n# Case/Examination\n# Differential Diagnosis, Investigations, and Treatment\n# Outcome and Follow-Up","[{\"question\":\"What does “multiple primary cancers” mean in this case report?\",\"answer\":\"It refers to the occurrence of more than one primary cancer in a single patient as synchronous or metachronous disease, without including metastases of a primary cancer.\"},{\"question\":\"How were the three primary cancers identified over time?\",\"answer\":\"The patient was initially diagnosed with breast carcinoma in situ after biopsy and lumpectomy, later developed esophageal squamous cell carcinoma after evaluation of progressive dysphagia, and was then found to have a renal mass diagnosed as papillary renal cell carcinoma after imaging and renal mass biopsy.\"},{\"question\":\"What treatments were used for the patient’s cancers?\",\"answer\":\"Management included breast lumpectomy and radiotherapy, non-surgical therapy for the esophageal cancer with chemotherapy and radiation, and right partial nephrectomy for the renal cancer.\"}]","Three Different Primary Cancers, Including Breast, Esophagus, and Renal in a Single Patient - A Case Report | PDF",1790191617,13]