[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-458430-105":59,"doc-detail-458430-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","thermoresponsive-magnetic-hydrogel-for-local-thermal-ablation-treatment-of-rectal-cancer","Thermoresponsive Magnetic Hydrogel for Local Thermal Ablation Treatment of Rectal Cancer","","Thermal ablation treats cancer by elevating local tumor temperature above 50 °C to trigger coagulative necrosis, but conventional delivery relies on invasive needle-like applicators that can limit rectal use. This study develops a magnetic hydrogel for localized rectal cancer ablation and preoperative tumor downsizing using superparamagnetic iron oxide nanoparticles dispersed in the thermoresponsive polymer Pluronic F127. External alternating magnetic fields activate the SPIONs to generate heat in situ. The formulation gels rapidly at physiological temperature, reduces spread, reaches above-threshold temperatures within minutes, and shows tumor volume reductions ex vivo and in vivo in colorectal cancer xenograft mice, supporting its role as an alternative when surgery or chemoradiotherapy is infeasible.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/thermoresponsive-magnetic-hydrogel-for-local-thermal-ablation-treatment-of-rectal-cancer/458430/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/thermoresponsive-magnetic-hydrogel-for-local-thermal-ablation-treatment-of-rectal-cancer/458430.png","ImageObject",300,407,{"name":92,"@type":93},"Bintang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does the magnetic hydrogel enable localized thermal ablation for rectal cancer?","Question",{"text":112,"@type":113},"The formulation uses superparamagnetic iron oxide nanoparticles embedded in a thermoresponsive Pluronic F127 gel. After the gel is immobilized at the application site, an external alternating magnetic field activates the nanoparticles to generate heat in situ and raise local tumor temperature above 50 °C.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What thermoresponsive behavior does Pluronic F127 provide in this treatment?",{"text":117,"@type":113},"Pluronic F127 exhibits sol-to-gel behavior at physiological temperature. Upon contact with tissue, the formulation rapidly gels and becomes immobilized, helping minimize spread to adjacent healthy tissue.",{"name":119,"@type":110,"acceptedAnswer":120},"What heating performance was observed under an alternating magnetic field?",{"text":121,"@type":113},"When exposed to a 14 mT alternating magnetic field at 596.2 kHz, the magnetic hydrogel reached temperatures above the thermal ablation threshold (50 °C) within 3 minutes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},458430,1790794202,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962085564381,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","| [www.acsami.org](www.acsami.org)  Research Article \u003Cbr>Thermoresponsive Magnetic Hydrogel for Local Thermal Ablation Treatment of Rectal Cancer\u003Cbr>Yuming Zhang, Christina Paraskeva, Isha Shaffir, Marco Tjakra, Vasiliki Koliaraki, and Alexandra Teleki *\u003Cbr> Cite This: [https://doi.org/10.1021/acsami.5c22174](https://doi.org/10.1021/acsami.5c22174)\u003Cbr>\u003Cbr> Read Online |  |  |  |  |  |\n| --- | --- | --- | --- | --- | --- |\n| ACCESS   | Metrics & More |  |  Article Recommendations |  | *sı Supporting Information |\n\nThis article is licensed under CC-BY 4.0  \nThis article is licensed under CC-BY 4.0   \nABSTRACT: Thermal ation treats cancer by raising local  \ntumor temperature above 50 °C to induce coagulative necrosis. However, current approaches are invasive, as they typically require needle-like applicators to deliver thermal energy directly into the tumor. In this study, a magnetic hydrogel was developed as anoninvasive strategy for localized rectal cancer ablation aimed at preoperative tumor downsizing. The formulation comprises superparamagnetic iron oxide nanoparticles (SPIONs: Mn0.6Zn0.4Fe2O4) dispersed in Pluronic F127 (PF127). PF127 confers thermoresponsive sol−gel behavior at physiological temperature: upon contact with tissue, the formulation rapidly gels and becomes immobilized at the application site, minimizing  \nspread to adjacent healthy tissue. After gel placement, an alternating magnetic field (AMF) is applied externally to activate the SPIONs to generate heat in situ, inducing local thermal ablation at the disease site. The gel can be administered either by syringe injection or by topical application, depending on tumor geometry. Adding SPIONs to the PF127 matrix did not alter the critical gelation temperature (CGT, 27.7 °C) but increased gel hardness and adhesiveness. When exposed to a 14 mT AMF at 596.2 kHz, the magnetic hydrogel exhibited excellent heating performance, reaching temperatures above the thermal ablation threshold (50 °C) within 3 min. The thermal ablation efficacy of the magnetic hydrogel was evaluated both ex vivo and in vivo using colorectal cancer xenograft mouse models. Ex vivo studies showed that a 15 min thermal ablation treatment resulted in an immediate 30% reduction in tumor volume. In vivo, a more pronounced effect was observed, with tumor volume decreased 69% 2 days after a single 20 min treatment. The finding highlighted the potential of the magnetic hydrogel as an alternative treatment for localized rectal cancer, either for preoperative tumor down-sizing or in cases where standard therapies such as surgery or chemo-radiotherapy are not feasible.  \nKEYWORDS: superparamagnetic iron oxide nanoparticle, magnetic hyperthermia, alternating magnetic field, critical gelation temperature, nanomedicine, doped ferrite, thermoresponsive polymer, flame spray pyrolysis  \n■ INTRODUCTION  \nColorectal cancer (CRC) is the second most frequently diagnosed cancer and the second leading cause of cancerrelated death in the European Union.1 Rectal cancer accounts for approximately 35% of all CRC cases.2 Standard management is stage-dependent and typically includes local excision with adjuvant or neoadjuvant chemoradiotherapy to downsize tumors and improve resectability, particularly in stage II−III disease.3 However, several weeks of chemoradiation can substantially diminish patients’ quality of life prior to surgery, and a considerable proportion of patients develop resistance during treatment. In addition, some tumors are considered surgically inaccessible because of proximity to critical pelvic structures or patient comorbidities.  \nThermal ablation is an alternative local treatment that eradicates malignant tissue by elevating intratumoral temperature (typically ≥ 50 °C). Common clinical modalities include radiofrequency, microwave, laser, and focused ultrasound  \nablation, delivered via image-guided, needle-like applicators positioned within the tumor.4 While effective and applicable in certain tumo","cbCaiqjL1rvn2l0I","https://ap.wps.com/l/cbCaiqjL1rvn2l0I","pdf",14445624,13,"English","# Abstract\n# Introduction\n## Current rectal cancer management\n## Limitations of conventional thermal ablation modalities\n## Motivation for less invasive localized heating","[{\"question\":\"How does the magnetic hydrogel enable localized thermal ablation for rectal cancer?\",\"answer\":\"The formulation uses superparamagnetic iron oxide nanoparticles embedded in a thermoresponsive Pluronic F127 gel. After the gel is immobilized at the application site, an external alternating magnetic field activates the nanoparticles to generate heat in situ and raise local tumor temperature above 50 °C.\"},{\"question\":\"What thermoresponsive behavior does Pluronic F127 provide in this treatment?\",\"answer\":\"Pluronic F127 exhibits sol-to-gel behavior at physiological temperature. Upon contact with tissue, the formulation rapidly gels and becomes immobilized, helping minimize spread to adjacent healthy tissue.\"},{\"question\":\"What heating performance was observed under an alternating magnetic field?\",\"answer\":\"When exposed to a 14 mT alternating magnetic field at 596.2 kHz, the magnetic hydrogel reached temperatures above the thermal ablation threshold (50 °C) within 3 minutes.\"}]","Thermoresponsive Magnetic Hydrogel for Local Thermal Ablation Treatment of Rectal Cancer | PDF",1790753019,33]