[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-342608-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-342608-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","therapeutic-potential-of-fungal-terpenes-and-terpenoids-application-in-skin-diseases","Therapeutic Potential of Fungal Terpenes and Terpenoids: Application in Skin Diseases","","Terpenes and terpenoids from fungi are highlighted as a diverse set of natural compounds with versatile medicinal value. The review outlines their general characteristics, including structure and biogenesis, then synthesizes evidence on therapeutic properties, mechanisms of action, and potential dermatological uses. Reported isolated compounds show anti-inflammatory and anti-microbial activity and may rival or exceed current therapies. Antioxidant and anti-cancer effects support roles in skin cancer prevention and treatment, while tyrosinase inhibition suggests relevance to pigmentation disorders and melanogenesis-related cancers, integrating clinical and in vivo findings.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/therapeutic-potential-of-fungal-terpenes-and-terpenoids-application-in-skin-diseases/342608/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/therapeutic-potential-of-fungal-terpenes-and-terpenoids-application-in-skin-diseases/342608.png","ImageObject",300,407,{"name":42,"@type":43},"Lucas Martin","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What compounds does the review focus on, and why are they significant for medicine?","Question",{"text":63,"@type":64},"The review focuses on fungal terpenes and terpenoids, emphasizing their diverse structures and versatile medicinal properties, including anti-inflammatory, anti-microbial, antioxidant, and anti-cancer activities.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which therapeutic benefits are reported for fungal terpenes and terpenoids in skin conditions?",{"text":68,"@type":64},"Isolated compounds are reported to reduce inflammation and inhibit microbes. They also show antioxidant and anti-cancer potential, and inhibit tyrosinase, which may help with pigmentation disorders and melanogenesis-related cancers.",{"name":70,"@type":61,"acceptedAnswer":71},"How does the review describe the mechanisms and research evidence behind these effects?",{"text":72,"@type":64},"It explains that fungal terpenoids may modulate signaling pathways, affect gene expression, and interact with key molecular targets. The review also disseminates findings from clinical and in vivo studies gathered so far.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},342608,1790619848,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":127,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","molecules   \nReview  \nTherapeutic Potential of Fungal Terpenes and Terpenoids: Application in Skin Diseases  \nMonika Trepa 1,2, Katarzyna Sułkowska-Ziaja 1, *, Katarzyna Kała 1 and Boena Muszy ´nska 1  \nCitation:  \nTrepa, M.; Sułkowska-Ziaja, K.; Kała, K.; Muszy ´nska, B. Therapeutic Potential of Fungal Terpenes and Terpenoids: Application in Skin Diseases. Molecules 2024, 29, 1183 . [https://doi.org/10.3390/molecules](https://doi.org/10.3390/molecules)[ ](https://doi.org/10.3390/molecules)29051183  \nAcademic Editors: Arjun H. Banskota and Francisco Leon  \nReceived: 23 December 2023  \nRevised: 3 March 2024  \nAccepted: 4 March 2024  \nPublished: 6 March 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Pharmaceutical Botany, Faculty of Pharmacy, Collegium Medicum, Jagiellonian University, 9 Medyczna St., 30-688 Kraków, Poland; [monika.trepa@doctoral.uj.edu.pl](monika.trepa@doctoral.uj.edu.pl) (M.T.); [k.kala@uj.edu.pl](k.kala@uj.edu.pl) (K.K.); [bozena.muszynska@uj.edu.pl](bozena.muszynska@uj.edu.pl) (B.M.)  \n2 Doctoral School of Medical and Health Sciences, Collegium Medicum, Jagiellonian University,  \n16 ´Sw. Łazarza St., 30-530 Kraków, Poland  \n* Correspondence: [katarzyna.sulkowska-ziaja@uj.edu.pl](katarzyna.sulkowska-ziaja@uj.edu.pl)  \nAbstract: Terpenes and their derivatives comprise a diverse group of natural compounds with versatile medicinal properties. This article elucidates the general characteristics of fungal terpenes and terpenoids, encompassing their structure and biogenesis. The focal point of this work involves a comprehensive overview of these compounds, highlighting their therapeutic properties, mechanisms of action, and potential applications in treating specific skin conditions. Numerous isolated terpenes and terpenoids have demonstrated noteworthy anti-inflammatory and anti-microbial effects, rivalling or surpassing the efficacy of currently employed treatments for inflammation or skin infections. Due to their well-documented antioxidant and anti-cancer attributes, these compounds exhibit promise in both preventing and treating skin cancer. Terpenes and terpenoids sourced from fungi display the capability to inhibit tyrosinase, suggesting potential applications in addressing skin pigmentation disorders and cancers linked to melanogenesis dysfunctions. This paper further disseminates the findings of clinical and in vivo research on fungal terpenes and terpenoids conducted thus far.  \nKeywords: fungal terpenes and terpenoids classification; skin diseases; skin cancer; anti-inflammatory; inhibition of tyrosinase  \n1. Introduction  \nFungi represent a valuable reservoir of bioactive molecules, serving as secondary metabolites with promising therapeutic attributes [1] . These molecules encompass various compounds, including terpenes and terpenoids, which are distinguished by their diverse chemical structures [2] . The heterogeneity within terpene compound classes contributes to a wide array of biological activities. From the well-established anti-cancer and antiinflammatory properties of sesquiterpenes to the anti-microbial activity of monoterpenes, the chemical diversity exhibited by fungal terpenes and terpenoids provides a versatile toolkit for potential therapeutic applications [3] .  \nThe skin, being the largest human organ, plays a pivotal role as a barrier against ex-ternal environmental factors and potential pathogens [4] . Conventional treatments often come with limitations such as side effects and incomplete efficacy. In response to these challenges, there has been a heightened search for alternative and complementary therapeutic agents, with a growing focus on natural compou","cbCaicXHF4zGpbJT","https://ap.wps.com/l/cbCaicXHF4zGpbJT","pdf",1027461,"English","# 1. Introduction\n## Fungal terpenes and terpenoids as bioactive molecules\n## Skin diseases and need for alternative therapies\n# Abstract\n# Keywords","[{\"question\":\"What compounds does the review focus on, and why are they significant for medicine?\",\"answer\":\"The review focuses on fungal terpenes and terpenoids, emphasizing their diverse structures and versatile medicinal properties, including anti-inflammatory, anti-microbial, antioxidant, and anti-cancer activities.\"},{\"question\":\"Which therapeutic benefits are reported for fungal terpenes and terpenoids in skin conditions?\",\"answer\":\"Isolated compounds are reported to reduce inflammation and inhibit microbes. They also show antioxidant and anti-cancer potential, and inhibit tyrosinase, which may help with pigmentation disorders and melanogenesis-related cancers.\"},{\"question\":\"How does the review describe the mechanisms and research evidence behind these effects?\",\"answer\":\"It explains that fungal terpenoids may modulate signaling pathways, affect gene expression, and interact with key molecular targets. The review also disseminates findings from clinical and in vivo studies gathered so far.\"}]","Therapeutic Potential of Fungal Terpenes and Terpenoids: Application in Skin Diseases | PDF",1790047365,48]