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MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate gene expression through post-transcriptional mechanisms. By modulating miRNA expression, TCMs have been shown to provide protective effects, particularly by promoting apoptosis. 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MicroRNAs (miRNAs) are endogenous, non-coding RNA (ncRNA) molecules that regulate genetic expression via post-transcriptional mechanisms. By modulating miRNA expression, TCMs have been proven to confer protective benefits, notably by facilitating apoptosis induction. Thus, exploring the molecular mechanisms implicating miRNAs within TCMs could offer potential avenues for developing novel strategies to mitigate various lethal illnesses. In this study, we aim to provide a concise overview delineating the contemporary understanding of the functions of TCMs in miRNA-mediated apoptosis across malignant and non-malignant pathologies, including cancer, neurological disorders, and cardiovascular diseases. This review will furnish valuable insights concerning the clinical utilization of TCMs in treatment and prevention across a spectrum of clinically relevant diseases and serve as a catalyst for the innovation of novel therapeutic agents to address these pathologies.\u003Cbr>Keywords: traditional Chinese medicine, miRNAs, apoptosis, malignant and non-malignant pathologies, molecular basis of TCMs in disease |\n| --- |\n| Introduction\u003Cbr>Examining the evolution of pharmaceutical development over the preceding fifty years reveals that natural resources constitute a noteworthy sector within the pharmaceutical industry when synthesized without specific design.1,2 Natural extracts and medicinal plants constitute a significant reservoir for advancing pharmaceutical research and developing therapeutic agents. TCM is a prominent exemplar among natural remedies, enjoying extensive global utilization as an adjunctive therapeutic approach across diverse maladies. TCMs have been extensively employed for millennia in China and neighboring Asian regions as integral modalities for preventive measures and therapeutic interventions across various diseases.3–9 Naturally occurring substances and medicinal plants represent a significant reservoir of biologically active compounds with therapeutic potential. Sourcing pharmaceutical agents from natural origins has enjoyed a longstanding tradition within medicine. Despite being employed for millennia in China and having significantly advanced human health, TCM continues to harbor substantial ambiguity regarding its molecular-level therapeutic mechanisms. Therefore, it is imperative to ascertain the primary components and comprehend the molecular m","cbCaiqStBXMfIMPM","https://ap.wps.com/l/cbCaiqStBXMfIMPM","pdf",7083481,31,"English","# Introduction\n## Evolution of natural resources in drug development\n## Therapeutic role and molecular uncertainty of TCM\n# microRNA-Modulated Mechanisms of TCM\n## miRNAs as regulators of post-transcriptional gene expression\n## miRNA-mediated apoptosis and disease contexts\n# Therapeutic implications across diseases\n## Malignant pathologies such as cancer\n## Non-malignant pathologies such as neurological and cardiovascular diseases","[{\"question\":\"Why is understanding TCM molecular mechanisms considered important?\",\"answer\":\"Despite long-term use and public health benefits, TCM still has substantial ambiguity regarding its molecular-level mechanisms. Identifying primary components and mechanisms is presented as necessary to guide development of new therapeutic agents.\"}]","Therapeutic Implications of Traditional Chinese Medicine in Clinically Relevant Diseases - Perspectives From microRNA-Modulated Apoptotic Signaling | PDF",1790192741,78]