[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-376853-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-376853-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","therapeutic-and-diagnostic-applications-of-exosomal-circrnas-in-breast-cancer","Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer","","Circular RNAs (circRNAs) function as regulatory elements that orchestrate gene expression and protein activities, with established roles in multiple cancer processes. Breast cancer remains a common malignancy and a major cause of mortality in women. circRNAs contribute to initiation, progression, metastasis, and therapy resistance, including via miRNA sponge mechanisms, protein interactions, and signaling pathway modulation. The review also evaluates circRNAs as diagnostic biomarkers and therapeutic targets, focusing on exosome-related interactions and available databases and tools while addressing clinical challenges and future prospects.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/therapeutic-and-diagnostic-applications-of-exosomal-circrnas-in-breast-cancer/376853/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/therapeutic-and-diagnostic-applications-of-exosomal-circrnas-in-breast-cancer/376853.png","ImageObject",300,407,{"name":42,"@type":43},"Aurelia","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How do exosomal circRNAs contribute to breast cancer biology?","Question",{"text":63,"@type":64},"circRNAs influence breast cancer through regulatory effects on gene expression and protein functions. They participate in initiation, progression, metastasis, and drug resistance, including through miRNA sponge activity and protein/signaling interactions.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Why are circRNAs considered promising diagnostic biomarkers?",{"text":68,"@type":64},"circRNAs can differentiate disease states due to properties such as stability, specificity, and sensitivity. They can be detected in biological specimens including blood, saliva, and urine.",{"name":70,"@type":61,"acceptedAnswer":71},"What therapeutic potential is discussed for circRNAs in breast cancer?",{"text":72,"@type":64},"The review discusses circRNAs as potential therapeutic targets, supported by their ability to modulate cancer-related intracellular pathways and biological processes integral to tumor development and progression. 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Ashour2 · Gianfranco Pintus3 · Mohamed Hammad4 · Manoj Kumar Kashyap5,6 · George Priya Doss C1 · Hatem Zayed7  \nReceived: 5 October 2022 / Revised: 29 April 2023 / Accepted: 2 May 2023 / Published online: 27 May 2023  \nThis is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023  \nAbstract  \nCircular RNAs (circRNAs) are regulatory elements that are involved in orchestrating gene expression and protein functions and are implicated in various biological processes including cancer. Notably, breast cancer has a significant mortality rate and is one of the most common malignancies in women. CircRNAs have been demonstrated to contribute to the pathogenesis of breast cancer including its initiation, progression, metastasis, and resistance to drugs. By acting as miRNA sponges, circRNAs can indirectly influence gene expression by disrupting miRNA regulation of their target genes, ultimately altering the course of cancer development and progression. Additionally, circRNAs can interact with proteins and modulate their functions including signaling pathways involved in the initiation and development of cancer. Recently, circRNAs can encode peptides that play a role in the pathophysiology of breast cancer and other diseases and their potential as diagnostic biomarkers and therapeutic targets for various cancers including breast cancer. CircRNAs possess biomarkers that differentiate, such as stability, specificity, and sensitivity, and can be detected in several biological specimens such as blood, saliva, and urine. Moreover, circRNAs play an important role in various cellular processes including cell proliferation, differentiation, and apoptosis, all of which are integral factors in the development and progression of cancer. This review synthesizes the functions of circRNAs in breast cancer, scrutinizing their contributions to the onset and evolution of the disease through their interactions with exosomes and cancer-related intracellular pathways. It also delves into the potential use of circRNA as a biomarker and therapeutic target against breast cancer. It discusses various databases and online tools that offer crucial circRNA information and regulatory networks. Lastly, the challenges and prospects of utilizing circRNAs in clinical settings associated with breast cancer are explored.  \nKeywords Breast cancer · circRNA · miRNA sponges · circRNA biomarkers · Exosomal circRNAs · Tumor-suppressivecircRNAs  \n*  \n*  \n1  \n2  \n3  \nGeorge Priya Doss C [georgepriyadoss@vit.ac.in](georgepriyadoss@vit.ac.in)  \nHatem Zayed  \n[hatem.zayed@qu.edu.qa](hatem.zayed@qu.edu.qa)  \nLaboratory of Integrative Genomics, Department of Integrative Biology, School of BioSciencesand Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, India  \nDepartment of Integrative Biology, College of Arts and Sciences, University of South Florida, St. Petersburg, Florida 33701, USA  \nDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy  \n4 Department of Stem Cell Biology and Regenerative Medicine, City of Hope Beckman Research Institute, Duarte, California, USA  \n5 Amity Stem Cell Institute, Amity Medical School, Amity University Haryana, Manesar (Gurugram), Panchgaon, Haryana (HR) 122413, India  \n6 Clinical Biosamples & Research Services (CBRS), Noida, Uttar Pradesh 201301, India  \n7 Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, 2713 Doha, Qatar  \nIntroduction  \nAbout 2% of DNA transcripts in the genome of eukaryotic organisms can be translated into functional proteins (Djebali et al. 2012) . The remaining 98% of the noncoding RNA ","cbCaimEjUpJ9YzgK","https://ap.wps.com/l/cbCaimEjUpJ9YzgK","pdf",2350291,"English","# Abstract\n# Introduction\n## Key concepts of ncRNA and circRNA biogenesis\n## circRNA classifications and mechanisms\n## Biological roles in cancer progression\n# Therapeutic and diagnostic applications (review scope)","[{\"question\":\"How do exosomal circRNAs contribute to breast cancer biology?\",\"answer\":\"circRNAs influence breast cancer through regulatory effects on gene expression and protein functions. They participate in initiation, progression, metastasis, and drug resistance, including through miRNA sponge activity and protein/signaling interactions.\"},{\"question\":\"Why are circRNAs considered promising diagnostic biomarkers?\",\"answer\":\"circRNAs can differentiate disease states due to properties such as stability, specificity, and sensitivity. They can be detected in biological specimens including blood, saliva, and urine.\"},{\"question\":\"What therapeutic potential is discussed for circRNAs in breast cancer?\",\"answer\":\"The review discusses circRNAs as potential therapeutic targets, supported by their ability to modulate cancer-related intracellular pathways and biological processes integral to tumor development and progression. It also addresses clinical challenges and prospects for translating circRNAs into practice.\"}]","Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer | PDF",1790221678]