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This study evaluates Thin Layer Cytology (TLC) for diagnosing metastatic neoplasms and their origins in pericardial effusions, and for monitoring chemotherapy response. Methods: 184 pericardial fluids were analyzed using the ThinPrep liquid-based technique with immunocytochemical markers; 53 lung and breast cancer patients were assessed for treatment response. Results: 113/184 were malignant; 71 were negative. After the third cisplatin orthiotepa dose, a marked reduction in neoplastic burden was observed. Conclusions: TLC with immunocytochemistry supports diagnosis, management, and monitoring of intrapericardial chemotherapy responsiveness.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-value-of-thin-layer-cytology-in-cancer-patients-pericardial-effusions-research-study/365937/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-value-of-thin-layer-cytology-in-cancer-patients-pericardial-effusions-research-study/365937.png","ImageObject",300,407,{"name":92,"@type":93},"วิน","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main clinical purpose of using Thin Layer Cytology in this study?","Question",{"text":112,"@type":113},"To diagnose metastatic pericardial malignancy, determine the origin of metastatic neoplasms in pericardial effusions, and help monitor response to chemotherapy to reduce risk of cardiac tamponade.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were pericardial fluid specimens processed and evaluated?",{"text":117,"@type":113},"A total of 184 pericardial fluids collected by pericardiocentesis were processed using the ThinPrep liquid-based Thin Layer Cytology technique, with immunocytochemical markers to determine tumor origin.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment-response finding was reported for chemotherapy in the pericardial fluid?",{"text":121,"@type":113},"In 53 chemotherapy-treated patients, cytologic examination showed a remarkable reduction in neoplastic burden after the third dose of cisplatin orthiotepa instilled into the pericardial cavity.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},365937,1790457595,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336475104736,"https://ap-avatar.wpscdn.com/avatar/22000c4c5e0e5b17e70?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786591360781797222","Article  \nThe Value of Thin Layer Cytology in Cancer Patients’Pericardial Effusions  \nChristos Lafaras 1, *, Evdokia Mandala 2, Kyranna Lafara 2, Ioannis Kalafatis 1, Thomas Achladas 2, Vasiliki Koukoulitsa 1, Chrysoula Gouta 3, Theodora Tsiouda 4 and Soultana Skevoudi 3  \nReceived: 9 March 2025  \nRevised: 13 May 2025  \nAccepted: 22 May 2025  \nPublished: 26 May 2025  \nCitation: Lafaras, C.; Mandala, E.; Lafara, K.; Kalafatis, I.; Achladas, T.; Koukoulitsa, V.; Gouta, C.; Tsiouda, T.; Skevoudi, S. The Value of Thin Layer Cytology in Cancer Patients’Pericardial Effusions. Curr. Oncol. 2025, 32, 306. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/curroncol32060306](10.3390/curroncol32060306)  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Cardiology-Oncology Department, Theagenion Cancer Hospital, PC54623 Thessaloniki, Greece; [jkal71@gmail.com](jkal71@gmail.com) (I.K.); [vkoukoul@yahoo.gr](vkoukoul@yahoo.gr) (V.K.)  \n2 Division of Hematology, Forth Department of Medicine, School of Medicine Aristotle University of Thessaloniki, PC54623 Thessaloniki, Greece; [eudokiamandala@gmail.com](eudokiamandala@gmail.com) (E.M.); [kyralafa@gmail.com](kyralafa@gmail.com) (K.L.); [axladtom@gmail.com](axladtom@gmail.com) (T.A.)  \n3 Department of Cytopathology, Theagenion Cancer Hospital, PC54623 Thessaloniki, Greece; [ch.gouta@gmail.com](ch.gouta@gmail.com) (C.G.); [tskevoudi@gmail.com](tskevoudi@gmail.com) (S.S.)  \n4 Pulmonology-Oncology Department, Theagenion Cancer Hospital, PC54623 Thessaloniki, Greece; [doratsiouda@yahoo.gr](doratsiouda@yahoo.gr)  \n* Correspondence: [lafarasc@gmail.com](lafarasc@gmail.com); Tel.: +30-2310224428  \nAbstract: Objective: Early diagnosis and treatment of metastatic pericardial disease are crucial to prevent the life-threatening complication of cardiac tamponade. Thin Layer Cytology (TLC), a widely adopted technique in cytology, has gained significant acceptance for most specimens. Our study aimed to assess the utility of TLC in diagnosing metastatic neoplasms and their origins in pericardial effusions, as well as monitoring response to chemotherapy. Methods: We examined 184 pericardial fluids collected by pericardiocentesis and processed using the ThinPrep liquid-based technique. Various immunocytochemical markers were used to determine the site of metastatic neoplasms. We also evaluated the response to therapy in 53 patients with lung and breast cancer. Results: Out of 184 specimens, 113 pericardial fluids were diagnosed as positive for malignancy, while 71 were negative. Twenty-three cases of unknown primary site were included in the total positive cases. Ninety cases positive for malignancy had a known primary site of origin, including 31 lung carcinomas, 22 breast carcinomas, 10 ovarian carcinomas, 6 T-cell lymphomas, 3 urinary bladder carcinomas, 4 renal carcinomas, 5 adenocarcinomas of the colon, 5 prostate carcinomas, 2 parotid adenocarcinomas, and 2 melanomas. Regarding the 53 cases with chemotherapy treatment, the cytologic examination of pericardial fluid showed a remarkable reduction in neoplastic burden after the third dose of cisplatin orthiotepa instilled into the pericardial cavity. ThinPrep provided excellent preservation of cytomorphological features, high cellularity per slide, and a clear background. This comprehensive analysis provides crucial information about the types and distribution of cancerous cells present in the samples. Conclusions: Thin Layer Cytology (TLC) is a valuable diagnostic tool for detecting metastatic pericardial malignancy. It allows the examination of exfoliated cells from the pericardial fluid, providing crucial information for diagnosis, management, and monit","cbCaitT6VcY87plW","https://ap.wps.com/l/cbCaitT6VcY87plW","pdf",1375459,15,"English","# Abstract\n# Introduction\n## Pericardial disease in cancer patients\n## Diagnosis and treatment approaches","[{\"question\":\"What is the main clinical purpose of using Thin Layer Cytology in this study?\",\"answer\":\"To diagnose metastatic pericardial malignancy, determine the origin of metastatic neoplasms in pericardial effusions, and help monitor response to chemotherapy to reduce risk of cardiac tamponade.\"},{\"question\":\"How were pericardial fluid specimens processed and evaluated?\",\"answer\":\"A total of 184 pericardial fluids collected by pericardiocentesis were processed using the ThinPrep liquid-based Thin Layer Cytology technique, with immunocytochemical markers to determine tumor origin.\"},{\"question\":\"What treatment-response finding was reported for chemotherapy in the pericardial fluid?\",\"answer\":\"In 53 chemotherapy-treated patients, cytologic examination showed a remarkable reduction in neoplastic burden after the third dose of cisplatin orthiotepa instilled into the pericardial cavity.\"}]","The Value of Thin Layer Cytology in Cancer Patients’ Pericardial Effusions - Research Study | PDF",1790163016,38]