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Methods: In a prospective study of 45 subjects (22 lung cancer, 2 precancerous, 14 healthy controls, 7 benign lung lesions), circulating tumor cells were detected using an innovated conical microfilter integrated microfluidic system. ROC AUCs were calculated for circulating tumor cells, cytokeratin19 fragment, CEA, SCC, NSE, their combination, and compared between venous and arterial samples. Results: Sensitivity and specificity were 81.8% and 90.5%; the highest AUC was achieved by CTC plus four markers (0.847). Conclusion: Conical microfilter microfluidics supports high-accuracy lung cancer diagnosis; venous blood is suitable for routine CTC detection.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-value-of-circulating-tumor-cells-and-tumor-markers-detection-in-lung-cancer-diagnosis-article/405584/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-value-of-circulating-tumor-cells-and-tumor-markers-detection-in-lung-cancer-diagnosis-article/405584.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",16,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How were circulating tumor cells detected in this study?","Question",{"text":113,"@type":114},"They were detected using an innovated conical microfilter integrated microfluidic system embedded in a microfluidic chip to improve CTC detection capability.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What subjects were included in the prospective study?",{"text":118,"@type":114},"The study recruited 45 subjects: 22 lung cancer patients, 2 precancerous patients, 14 healthy participants as controls, and 7 patients with benign lung lesions.",{"name":120,"@type":111,"acceptedAnswer":121},"Which biomarkers produced the best diagnostic performance?",{"text":122,"@type":114},"The combination of circulating tumor cells and four conventional tumor markers achieved the highest ROC AUC value (0.847), exceeding the AUC of individual markers.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},405584,1790824283,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","The Value of Circulating Tumor Cells and Tumor Markers Detection in Lung Cancer Diagnosis  \nSumin Guo, MD 1, Jingyu Chen, BS2, Po Hu, MD3, Chen Li, MD3, Xiang Wang, MD3, Ning Chen, PhD4, Jiale Sun5, Yongfeng Wang, BS3, Jianling Wang, BS3, Weikuan Gu, PhD6 , and Shucai Wu, MD 1,7  \nTechnology in Cancer Research & Treatment  \nVolume 22: 1-11  \n© The Author(s) 2023  \nArticle reuse guidelines: [sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/15330338231166754](DOI: 10.1177/15330338231166754)[ ](DOI: 10.1177/15330338231166754)[journals.sagepub.com/home/tct](journals.sagepub.com/home/tct)  \nAbstract  \nObjective: Circulating tumor cells are complete tumor cells with multi-scale analysis values that present a high potential for lung cancer diagnosis. To enhance the accuracy of lung cancer diagnosis, we detected circulating tumor cells by the innovated conical micro filter integrated microfluidic system. Methods: We recruited 45 subjects of study, including 22 lung cancer patients, 2 precancerous patients, the control group including 14 healthy participants, and 7 patients with lung benign lesions in this prospective study. We calculated the area under the receiver operating characteristic curve of circulating tumor cells, cytokeratin19 fragment, carcinoma embryonic antigen, squamous cell carcinoma, neuron-specific enolase, and their combination, respectively, while compared the circulating tumor cells levels between vein blood and arterial blood. A conical shape filter embedded in a microfluidic chip was used to improve the detection capability of circulating tumor cells. Results: The study indicated that the sensitivity, specificity, positive predictive value, and negative predictive value of circulating tumor cells detection were 81.8%, 90.5%, 90.0%, and 82.6%, respectively. The circulating tumor cells level of lung cancer patient was significantly higher than that of the control group (P \u003C .05). The area under the curve of circulating tumor cells, cytokeratin19 fragment, carcinoma embryonic antigen, squamous cell carcinoma, and neuron-specific enolase alone was 0.838, 0.760, 0.705, 0.614, and 0.636, respectively. The combination area under the curve of the 4 tumor markers (cytokeratin19 fragment, carcinoma embryonic antigen, squamous cell carcinoma, and neuron-specific enolase) was 0.805 less than that of circulating tumor cells alone. Together, the total area under the curve of circulating tumor cell and the 4 tumor markers were 0.847, showing the highest area under the curve value among all biomarkers. In addition, this study found that there was no significant difference in positive rate of circulating tumor cell between arterial and venous blood samples. Conclusion: The circulating tumor cells detection technology by conical micro filter integrated microfluidic could be used for lung cancer diagnosis with high sensitivity and specificity. Complementary combination of circulating tumor cells and conventional 4 lung cancer markers could enhance the clinical application accuracy. Venous blood should be used as a routine sample for circulating tumor cells detections.  \n1 Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China  \n2 Department of Chinese Medicine Internal Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China  \n3 Department of Oncology, Hebei Chest Hospital, Lung Cancer Prevention and Research Center of Hebei Province, Shijiazhuang, Hebei, People’s Republic of China  \n4 Department of Pathology, Hebei Chest Hospital, Lung Cancer Prevention and Research Center of Hebei Province, Shijiazhuang, Hebei, People’s Republic of China  \n5 College of Lab Medicine, Hebei North University, Zhangjiakou, Hebei, People’s Republic of China  \n6 Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, USA  \n7 Department o","cbCaibMHCMpxRmNf","https://ap.wps.com/l/cbCaibMHCMpxRmNf","pdf",6930411,11,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Materials and Methods\n# Results\n# Discussion\n# Conclusion","[{\"question\":\"How were circulating tumor cells detected in this study?\",\"answer\":\"They were detected using an innovated conical microfilter integrated microfluidic system embedded in a microfluidic chip to improve CTC detection capability.\"},{\"question\":\"What subjects were included in the prospective study?\",\"answer\":\"The study recruited 45 subjects: 22 lung cancer patients, 2 precancerous patients, 14 healthy participants as controls, and 7 patients with benign lung lesions.\"},{\"question\":\"Which biomarkers produced the best diagnostic performance?\",\"answer\":\"The combination of circulating tumor cells and four conventional tumor markers achieved the highest ROC AUC value (0.847), exceeding the AUC of individual markers.\"}]","The Value of Circulating Tumor Cells and Tumor Markers Detection in Lung Cancer Diagnosis - Article | PDF",1790560742,28]