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Lipidomic investigations have identified widespread disruptions in lipid profiles across cancers, and CRC studies suggest lipidomic signatures can support discovery of novel diagnostic and prognostic indicators. This systematic review evaluates recent literature on lipidomic markers for CRC by searching PubMed for eligible studies. Thirty-six articles were included, highlighting phosphatidylcholine, phosphatidylethanolamine, ceramides, and triacylglycerols as promising diagnostic candidates. The review also notes that standardized methods and large-scale studies are required for clinical translation, and that deeper mechanistic validation often depends on both cell culture and animal experiments.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-utility-of-lipidomic-analysis-in-colorectal-cancer-diagnosis-and-prognosis-a-systematic-review-of-recent-literature/332271/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-utility-of-lipidomic-analysis-in-colorectal-cancer-diagnosis-and-prognosis-a-systematic-review-of-recent-literature/332271.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the purpose of this systematic review on CRC lipidomics?","Question",{"text":112,"@type":113},"It reviews recent literature on lipidomic markers for colorectal cancer and assesses how lipidomic signatures may support diagnosis and prognosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which lipid species show notable diagnostic accuracy signals in the included studies?",{"text":117,"@type":113},"Phosphatidylcholine, phosphatidylethanolamine, ceramides, and triacylglycerols (TAGs) are described as offering the highest diagnostic accuracy.",{"name":119,"@type":110,"acceptedAnswer":120},"What steps are needed before lipidomic markers can be used clinically?",{"text":121,"@type":113},"Standardized methods and large-scale studies are necessary to enable clinical application, and thorough mechanistic analysis typically requires cell culture and animal studies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332271,1790912196,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nThe Utility of Lipidomic Analysis in Colorectal Cancer Diagnosis and Prognosis—A Systematic Review of Recent Literature  \nJakub Klekowski 1,2, Mariusz Chabowski 2,3, *, Małgorzata Krzystek-Korpacka 4 and Mariusz Fleszar 4,5  \nCitation: Klekowski, J.; Chabowski, M.; Krzystek-Korpacka, M.; Fleszar, M. The Utility of Lipidomic Analysis in Colorectal Cancer Diagnosis and Prognosis—A Systematic Review of Recent Literature. Int. J. Mol. Sci. 2024, 25, 7722. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms25147722  \nAcademic Editor: Zoltán Wiener  \nReceived: 13 May 2024  \nRevised: 7 July 2024  \nAccepted: 12 July 2024  \nPublished: 14 July 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Nursing and Obstetrics, Division of Anesthesiological and Surgical Nursing, Faculty of Health Science, Wroclaw Medical University, 50-367 Wroclaw, Poland; [klekowski.jakub@gmail.com](klekowski.jakub@gmail.com)  \n[2](2 Department of Surgery)[ Department of Surgery](2 Department of Surgery), [4th Military Clinical Hospital](4th Military Clinical Hospital), [50-981 Wroclaw](50-981 Wroclaw), [Poland](Poland)  \n3 Department of Clinical Surgical Sciences, Faculty of Medicine, Wroclaw University of Science and Technology, 50-556 Wroclaw, Poland  \n4 Department of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland; [malgorzata.krzystek-korpacka@umw.edu.pl](malgorzata.krzystek-korpacka@umw.edu.pl) (M.K.-K.); [mariusz.fleszar@umw.edu.pl](mariusz.fleszar@umw.edu.pl) (M.F.)  \n5 Omics Research Center, Wroclaw Medical University, 50-368 Wroclaw, Poland  \n* [Correspondence: mariusz.chabowski@gmail.com](Correspondence: mariusz.chabowski@gmail.com); Tel.: +48-261660247  \nAbstract: Colorectal cancer (CRC) is among the most prevalent and lethal malignancies. Lipidomic investigations have revealed numerous disruptions in lipid profiles across various cancers. Studies on CRC exhibit potential for identifying novel diagnostic or prognostic indicators through lipidomic signatures. This review examines recent literature regarding lipidomic markers for CRC. PubMed database was searched for eligible articles concerning lipidomic biomarkers of CRC. After selection, 36 articles were included in the review. Several studies endeavor to establish sets of lipid biomarkers that demonstrate promising potential to diagnose CRC based on blood samples. Phosphatidylcholine, phosphatidylethanolamine, ceramides, and triacylglycerols (TAGs) appear to offer the highest diagnostic accuracy. In tissues, lysophospholipids, ceramides, and TAGs were among the most altered lipids, while unsaturated fatty acids also emerged as potential biomarkers. In-depth analysis requires both cell culture and animal studies. CRC involves multiple lipid metabolism alterations. Although numerous lipid species have been suggested as potential diagnostic markers, the establishment of standardized methods and the conduct of large-scale studies are necessary to facilitate their clinical application.  \nKeywords: colorectal cancer; lipidomics; diagnosis; prognosis; biomarkers; mass spectrometry  \n1. Introduction  \nColorectal cancer (CRC) ranks as the third most prevalent malignant neoplasm globally and is the second leading cause of cancer-related mortality. The socioeconomic impact of the CRC is steadily rising, particularly in developed nations, largely attributed to lifestyle factors as primary risk determinants for its development. In 2020, there were an estimated 1.88 billion new cases of CRC diagnosed worldwide. Although CRC typically affects adults aged 60 and above, there is a growing incidence observed amon","cbCaifLTZj4ROgtZ","https://ap.wps.com/l/cbCaifLTZj4ROgtZ","pdf",774681,18,"English","# Introduction\n## Lipid-related context in CRC\n# Abstract\n## Diagnostic and prognostic value of lipidomic markers\n# Keywords\n## Lipidomic biomarkers and analytical approaches","[{\"question\":\"What is the purpose of this systematic review on CRC lipidomics?\",\"answer\":\"It reviews recent literature on lipidomic markers for colorectal cancer and assesses how lipidomic signatures may support diagnosis and prognosis.\"},{\"question\":\"Which lipid species show notable diagnostic accuracy signals in the included studies?\",\"answer\":\"Phosphatidylcholine, phosphatidylethanolamine, ceramides, and triacylglycerols (TAGs) are described as offering the highest diagnostic accuracy.\"},{\"question\":\"What steps are needed before lipidomic markers can be used clinically?\",\"answer\":\"Standardized methods and large-scale studies are necessary to enable clinical application, and thorough mechanistic analysis typically requires cell culture and animal studies.\"}]","The Utility of Lipidomic Analysis in Colorectal Cancer Diagnosis and Prognosis - A Systematic Review of Recent Literature | PDF",1789997614,45]