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The review explains photodynamic therapy (PDT) as a minimally invasive, side-effect-limited approach that activates a photosensitizing substance with visible light to generate cytotoxic oxygen radicals and destroy target cells. It summarizes current evidence, emphasizing growing research interest, mostly preclinical in vitro work, and the need for improved photosensitizers and optimized properties.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-use-of-photodynamic-therapy-in-the-treatment-of-endometrial-cancer-a-review-of-the-literature/333693/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-use-of-photodynamic-therapy-in-the-treatment-of-endometrial-cancer-a-review-of-the-literature/333693.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is photodynamic therapy (PDT) and how does it work?","Question",{"text":113,"@type":114},"PDT relies on a photosensitizer activated by a specific wavelength of visible light in the presence of tissue oxygen. 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The Use of Photodynamic Therapy in the Treatment of Endometrial Cancer—AReview of the Literature. Int. J. Mol. Sci. 2024, 25, 8772. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms25168772](10.3390/ijms25168772)  \nAcademic Editor: Kuo-Hu Chen  \nReceived: 27 June 2024  \nRevised: 3 August 2024  \nAccepted: 10 August 2024  \nPublished: 12 August 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Doctoral School, Medical College of the University of Rzeszów, 35-310 Rzeszów, Poland; [aleksandraz@dokt.ur.edu.pl](aleksandraz@dokt.ur.edu.pl)  \n2 Department of Midwifery, Medical College of the University of Rzeszów, 35-310 Rzeszów, Poland; [ebarnas@interia.eu](ebarnas@interia.eu)  \n3 Department of Biochemistry and General Chemistry, Medical College of the University of Rzeszów, 35-310 Rzeszów, Poland; [dbartusikaebisher@ur.edu.pl](dbartusikaebisher@ur.edu.pl)  \n4 Department of Photomedicine and Physical Chemistry, Medical College of the University of Rzeszów, 35-310 Rzeszów, Poland  \n* Correspondence: [daebisher@ur.edu.pl](daebisher@ur.edu.pl)  \nAbstract: Endometrial cancer is the most common malignant tumor of the female reproductive system. It develops in the mucous membrane lining the inside of the uterine body—the endometrium, through the abnormal and continuous growth of cancer cells originating from the uterine mucosa. In recent years, there has been a significant increase in the number of cases in European countries. Photodynamic therapy (PDT) is an innovative and dynamically developing medical procedure, useful in the treatment of cancer and non-cancer tissue conditions. The PDT reaction involves the activation of a photosensitizing substance with visible light, which in turn leads to the formation of free oxygen radicals, which contribute to the destruction of the cell. PDT is minimally invasive, has few side effects, and preserves organ anatomy and function. Both diagnostics and photodynamic therapy as modern methods of treatment are becoming more and more popular in many research units around the world. They are most often practiced and tested in in vitro experimental conditions. In clinical practice, the use of PDT is rare. Comprehensive cooperation between scientists contributes to taking steps towards obtaining new, synthetic photosensitizers, directing their physicochemical properties, and showing the impact on a given organism. This review examines the evidence for the potential and usefulness of PDT in the treatment of endometrial cancer. This review highlights that PDT is gaining popularity and is becoming a promising field of medical research.  \nKeywords: endometrial cancer; photodynamic therapy; photosensitizers  \n1. Introduction  \nThe photodynamic method is used in various fields of medicine, both in diagnostic processes (photodynamic diagnosis; PDD) and therapeutic processes (photodynamic therapy; PDT) . The therapy uses three basic components: a photosensitizer, a light source, and oxygen dissolved in the tissue. The interaction of a specific wavelength with a photosensitizer determines its activation and causes a photodynamic reaction (the chemical compound and the light are individually non-toxic, but in combination they destroy tissues) . The method is used in the diagnosis and treatment of pre-cancerous lesions and cancers of various types. PDT has a number of advantages. Photocytotoxi","cbCaibZqK3FUWwTd","https://ap.wps.com/l/cbCaibZqK3FUWwTd","pdf",882742,11,"English","# Introduction\n# Material and Methods\n# History of Photodynamic Therapy\n# Photodynamic Therapy Mechanism\n# Photosensitizers in Gynecological Oncology\n# Clinical Use and Research Perspectives","[{\"question\":\"What is photodynamic therapy (PDT) and how does it work?\",\"answer\":\"PDT relies on a photosensitizer activated by a specific wavelength of visible light in the presence of tissue oxygen. The activation produces free oxygen radicals that contribute to cell destruction.\"},{\"question\":\"What advantages of PDT are highlighted for endometrial cancer treatment?\",\"answer\":\"PDT is presented as minimally invasive, locally selective, with few side effects, and capable of preserving organ anatomy and function. It can be combined with standard treatments when appropriate.\"},{\"question\":\"How were studies selected in this literature review?\",\"answer\":\"The review used databases including Medline (via PubMed), Library, Embase, and Web of Science. Searches used terms related to endometrial cancer and photodynamic therapy, with Boolean operators, and included articles published in English and Polish.\"}]","The Use of Photodynamic Therapy in the Treatment of Endometrial Cancer - A Review of the Literature | PDF",1790003633,28]