[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330718-105":59,"doc-detail-330718-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-use-of-photodynamic-therapy-in-medical-practice","The use of photodynamic therapy in medical practice","","Cancer therapy, especially for tumors close to sensitive anatomical areas, requires accurate, targeted treatment. This review analyzes photodynamic therapy (PDT), explaining how photosensitizers, specific wavelength light, and oxygen work together to selectively attack cancer cells. It highlights evidence supporting PDT efficacy through reactive oxygen species and ROS-driven cancer cell death, and traces the evolution of PDT from early research to current clinical applications across dermatology, oncology, and dentistry. ",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-use-of-photodynamic-therapy-in-medical-practice/330718/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-use-of-photodynamic-therapy-in-medical-practice/330718.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is photodynamic therapy (PDT) and how is it delivered to the patient?","Question",{"text":112,"@type":113},"PDT combines a photosensitizer with dissolved oxygen and a specific wavelength of light. A patient is injected with the photosensitizer, followed by illumination of the diseased region after the drug-light interval.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does PDT cause cancer cell death?",{"text":117,"@type":113},"PDT generates reactive agents such as superoxide and hydroxyl radicals, which are responsible for eliciting cancer cell death. The process involves ROS generation that drives targeted cytotoxic effects.",{"name":119,"@type":110,"acceptedAnswer":120},"How did PDT develop historically and what role did ALA-based PDT play?",{"text":121,"@type":113},"The early observation was that microorganisms in an acridine orange solution died after sunlight exposure. 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Oncol. 14:1373263 .  \ndoi: 10.3389/fonc.2024.1373263  \nCOPYRIGHT  \n© 2024 Aebisher, Rogo´z˙, My´sliwiec, Dynarowicz, Wiench, Cie´slar, Kawczyk-Krupka and Bartusik-Aebisher. This is an open-access article distributed under the terms of the  \nCreative Commons Attribution License (CC BY) .  \nThe use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nThe use of photodynamic therapy in medical practice  \nDavid Aebisher 1*, Kacper Rogo´ ˙z2, Angelika My´sliwiec 3, Klaudia Dynarowicz 3, Rafał Wiench 4, Grzegorz Cie´slar 5, Aleksandra Kawczyk-Krupka 5 and Dorota Bartusik-Aebisher 6  \n1 Department of Photomedicine and Physical Chemistry, Medical College of The Rzeszo´w University, Rzeszo´w, Poland, 2 English Division Science Club, Medical College of The Rzeszo´w University, Rzeszo´w, Poland, 3Center for Innovative Research in Medical and Natural Sciences, Medical College of The University of Rzeszów, Rzeszo´w, Poland, 4 Department of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Zabrze, Poland, 5 Department of Internal Medicine, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Medical University of Silesia, Bytom, Poland, 6 Department of Biochemistry and General Chemistry, Medical College of The Rzeszo´ w University, Rzeszo´ w, Poland  \nCancer therapy, especially for tumors near sensitive areas, demands precise treatment. This review explores photodynamic therapy (PDT), a method leveraging photosensitizers (PS), specific wavelength light, and oxygen to target cancer effectively. Recent advancements affirm PDT’s efficacy, utilizing ROS generation to induce cancer cell death. With a history spanning over decades, PDT ’ s dynamic evolution has expanded its application across dermatology, oncology, and dentistry. This review aims to dissect PDT ’ s principles, from its inception to contemporary medical applications, highlighting its role in modern cancer treatment strategies.  \nKEYWORDS  \nphotodynamic therapy (PDT), medical practice, photosensitizers, treatment cancer, oncology  \n1 Introduction  \nPhotodynamic Therapy (PDT) is a treatment that uses a combination of lightabsorbing photosensitizers (PS) and dissolved oxygen to kill diseased cells. Briefly, a patient is injected with PS and, after a period of time known as the drug-light interval, the diseased region is illuminated with a specific wavelength of laser light. Superoxide (O2•-) and hydroxyl radical (OH · ), are the active agents responsible for eliciting cancer cell death as opposed to agents which are toxic to the body as a whole such as chemotherapy drugs and radiation. Photosensitizers- A photosensitizer is a chemical or compound that increases the sensitivity of the body or tissues to light, especially ultraviolet (UV) radiation or visible light. The effects of a photosensitizer may include hypersensitivity to light, allergic reactions or damage to skin cells under the influence of light radiation. For this reason, photosensitizers are used in photodynamic therapy. Reactive oxygen specie","cbCaiaAtaoEJWShv","https://ap.wps.com/l/cbCaiaAtaoEJWShv","pdf",1615840,25,"English","# 1 Introduction\n## Photosensitizers and ROS\n## History and clinical development\n## ALA-based photodynamic therapy (ALAPDT)","[{\"question\":\"What is photodynamic therapy (PDT) and how is it delivered to the patient?\",\"answer\":\"PDT combines a photosensitizer with dissolved oxygen and a specific wavelength of light. A patient is injected with the photosensitizer, followed by illumination of the diseased region after the drug-light interval.\"},{\"question\":\"How does PDT cause cancer cell death?\",\"answer\":\"PDT generates reactive agents such as superoxide and hydroxyl radicals, which are responsible for eliciting cancer cell death. The process involves ROS generation that drives targeted cytotoxic effects.\"},{\"question\":\"How did PDT develop historically and what role did ALA-based PDT play?\",\"answer\":\"The early observation was that microorganisms in an acridine orange solution died after sunlight exposure. Later, PDT gained attraction in cancer treatment, and ALA-based PDT was introduced clinically in 1990 by Kennedy and Pottier, followed by rapid development.\"}]","The use of photodynamic therapy in medical practice | PDF",1789989836,63]