[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-470010-105":59,"doc-detail-470010-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","the-trna-editing-complex-adat23-promotes-cancer-cell-growth-and-codon-biased-mrna-translation","The tRNA Editing Complex ADAT2/3 Promotes Cancer Cell Growth and Codon-biased mRNA Translation","","Transfer RNAs (tRNAs) carry chemical modifications that affect stability and function, including adenosine-to-inosine (A-to-I) editing at anticodon position A34. The tRNA editing complex ADAT2/3 catalyzes this modification and expands wobble-position decoding. The study shows ADAT2/3 genes are commonly amplified or overexpressed across tumor types, including liposarcoma, where ADAT2/3 editing activity supports cell growth and tumorigenicity.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-trna-editing-complex-adat23-promotes-cancer-cell-growth-and-codon-biased-mrna-translation/470010/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-trna-editing-complex-adat23-promotes-cancer-cell-growth-and-codon-biased-mrna-translation/470010.png","ImageObject",300,407,{"name":92,"@type":93},"moss~","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What role does A-to-I tRNA editing at A34 play in translation?","Question",{"text":113,"@type":114},"A-to-I editing in the tRNA anticodon at position A34 expands anticodon–codon recognition at the wobble position, altering decoding and the balance between codon usage and tRNA availability.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How are ADAT2/3 related to cancer cell growth in this study?",{"text":118,"@type":114},"Genes encoding the ADAT2/3 deaminase complex are commonly amplified or overexpressed in multiple tumor types, and liposarcoma growth and tumorigenicity depend on ADAT2/3 tRNA editing activity.",{"name":120,"@type":111,"acceptedAnswer":121},"What happens when ADAT2 is depleted?",{"text":122,"@type":114},"ADAT2 depletion decreases tRNA editing, causes defective translation of a subset of mRNAs, and leads to altered protein homeostasis, supporting the conclusion that ADAT2 promotes oncogenesis.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},470010,1791347771,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},962090895452,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Author Manuscr ipt Author Manuscr ipt Author Manuscr ipt Author Manuscript  \n\n| | HHS Public Access\u003Cbr>Author manuscript\u003Cbr>J Mol Biol. Author manuscript; available in PMC 2026 January 09. |\n| --- | --- |\n\nPublished in final edited form as:  \nJ Mol Biol. 2025 November 01; 437(21): 169414. doi:10.1016/j.jmb.2025.169414 .  \nThe tRNA Editing Complex ADAT2/3 Promotes Cancer Cell Growth and Codon-biased mRNA Translation☆  \nJulia Ramirez-Moya 1,2,3 , Titi Rindi Antika 1,2,3,4 , Qi Liu 1,2,3,5,6 , Xushen Xiong 1,2,3,7 , Raja Ali2 , Alejandro Gutierrez2,8,9 , Richard I. Gregory 1,2,3,4,8,10  \n1Stem Cell Program, Boston Children’s Hospital, Boston, MA 02115, USA  \n2 Division of Hematology/Oncology, Boston Children’s Hospital, Boston, MA 02115, USA  \n3 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA  \n4Molecular, Cell, and Cancer Biology Department, UMass Chan Medical School, Worcester, MA 01605, USA  \n5 Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640 Guangdong Province, China  \n6Guangdong Key Laboratory of New Technology in Rice Breeding, Guangzhou 510640 Guangdong Province, China  \n7Zhejiang University Medical Center, Hangzhou, Zhejiang Province, China  \n8 Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA  \n9 Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA  \n10 Harvard Initiative for RNA Medicine, Boston, MA 02115, USA  \nAbstract  \nTransfer RNAs (tRNAs) are subject to various chemical modifications that influence their stability or function. Adenosine to Inosine (A-to-I) editing in the tRNA anticodon at position A34 isan important modification that expands anticodon-codon recognition at the wobble position and  \n☆This article is part of a special issue entitled: ‘tRNA modifications (2025)’ published in Journal of Molecular Biology.  \nThis is an open access article under the CC BY license ([https://creativecom-mons.org/licenses/by/4.0/](https://creativecom-mons.org/licenses/by/4.0/)).  \nCorrespondence to Richard I. Gregory: Stem Cell Program, Boston Children’s Hospital, Boston, MA 02115, USA.  \n[richard.gregory1@umassmed.edu](richard.gregory1@umassmed.edu) (R.I. Gregory).  \nDECLARATION OF COMPETING INTEREST  \nThe authors declare the following financial interests/personal relationships which may be considered as potential competing interests:‘R.I.G. is a co-founder, scientific advisory board member, and equity holder of Redona Therapeutics (formerly 28/7 Therapeutics), and advisor to Alida Biosciences, and to O2nix Bio. The Gregory lab has received research funding from Sanofi, Astellas, and Ono. All other authors declare no competing interests.’.  \nCRediT authorship contribution statement  \nJulia Ramirez-Moya: Writing – original draft, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Titi Rindi Antika: Writing – review & editing, Formal analysis, Data curation. Qi Liu: Methodology, Formal analysis, Data curation. Xushen Xiong: Formal analysis, Data curation. Raja Ali: Methodology, Investigation, Formal analysis. Alejandro Gutierrez:  \nSupervision, Project administration, Funding acquisition, Formal analysis, Conceptualization. Richard I. Gregory: Writing – review & editing, Writing – original draft, Supervision, Project administration, Funding acquisition, Formal analysis, Data curation, Conceptualization.  \nAuthor Manuscr ipt Author Manuscr ipt Author Manuscr ipt Author Manuscript  \nRamirez-Moya et al. Page 2  \nis required for normal mRNA translation. The relevance of tRNA editing in cancer remains unexplored. Here we show that the genes encoding the ADAT2/3 deaminase complex, responsible for A-to-I tRNA editing in humans, are commonly amplified and/or overexpressed in several tumor types including liposarcoma (LPS). We find that LPS cell growth and tumorigenicity is dependent on ADAT2/3 tRNA editing activity. Mechanistically, we find decreased tRNA editi","cbCaitjMlI5ZQBw3","https://ap.wps.com/l/cbCaitjMlI5ZQBw3","pdf",2251037,25,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"What role does A-to-I tRNA editing at A34 play in translation?\",\"answer\":\"A-to-I editing in the tRNA anticodon at position A34 expands anticodon–codon recognition at the wobble position, altering decoding and the balance between codon usage and tRNA availability.\"},{\"question\":\"How are ADAT2/3 related to cancer cell growth in this study?\",\"answer\":\"Genes encoding the ADAT2/3 deaminase complex are commonly amplified or overexpressed in multiple tumor types, and liposarcoma growth and tumorigenicity depend on ADAT2/3 tRNA editing activity.\"},{\"question\":\"What happens when ADAT2 is depleted?\",\"answer\":\"ADAT2 depletion decreases tRNA editing, causes defective translation of a subset of mRNAs, and leads to altered protein homeostasis, supporting the conclusion that ADAT2 promotes oncogenesis.\"}]","The tRNA Editing Complex ADAT2/3 Promotes Cancer Cell Growth and Codon-biased mRNA Translation | PDF",1790776556,63]