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This cross-sectional study assessed the trend of years of life lost (YLL) attributable to gastrointestinal cancers in Fars Province, southern Iran, over 2004–2019 using population-based death registration data. YLL was computed with the WHO 2015 template and joinpoint regression on a log-linear model evaluated temporal changes. Results quantified total YLL, sex distribution, and cancer-specific patterns.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-trend-of-years-of-life-lost-due-to-gastrointestinal-cancers-in-fars-iran-2004-2019/328208/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-trend-of-years-of-life-lost-due-to-gastrointestinal-cancers-in-fars-iran-2004-2019/328208.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What period and population were analyzed in this study?","Question",{"text":112,"@type":113},"The study analyzed deaths due to gastrointestinal cancers in Fars Province, southern Iran, during 2004–2019.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were years of life lost (YLL) calculated?",{"text":117,"@type":113},"YLL was calculated using the YLL template of 2015 by the WHO.",{"name":119,"@type":110,"acceptedAnswer":120},"What statistical approach was used to evaluate trends over time?",{"text":121,"@type":113},"Joinpoint regression based on a log-linear model was used to describe changing trends and the rate of increase or decrease across successive periods.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328208,1790061688,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","Iran J Public Health, Vol. 53, No.3, Mar 2024, pp.671-679  \n# Original Article\n\nThe Trend of Years of Life Lost due to Gastrointestinal Cancersin Fars (Iran) 2004-2019  \nHabibollah Azarbakhsh 1, Seyed Sina Dehghani 2, Jafar Hassanzadeh 3,Amir Hossein Hassani 2, Maryam Janfada 4, *AlirezaMirahmadizadeh 4  \n1. Department of Epidemiology, Faculty of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran  \n2. Social Medicine Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran  \n3. Department of Epidemiology, Research Centerfor Health Sciences, Institute of Health, Shiraz University of Medical Sciences, Shiraz,Iran  \n4. Non-Communicable Research Center, Shiraz University of Medical Sciences, Shiraz, Iran  \n*Corresponding Author: Email: mirahmadia@sums.ac.ir  \n(Received 20 Sep 2022; accepted 11 Dec 2022)  \n## Abstract\n\nBackground: Gastrointestinal cancers can cause major health problems globally since their burden is increas -ing in many countries. We aimed to investigate the trend of years of life lost due to gastrointestinal cancers inFars Province, southern Iran during the 2004-2019.  \nMethods: In this cross-sectional survey study, we obtained the information regarding all deaths due to gastro -intestinal cancers in Fars Province from the electronic population-based death registration system (EDRS) .Years of Life Lost (YLL) was calculated using the YLL template of 2015 by the WHO. To examine the trendfor different years, join point regression based on the log-linear model was used. Joinpoint regression analysisdescribes changing trends over successive periods of time and the increasing or decreasing rate within eachperiod.  \nResults: During the years of 2004-2019, 9742 deaths due to gastrointestinal cancers occurred in Fars Prov -ince. 6013 (61.72%) cases were male and 3729 (38.28%) cases were female (Male / Female Sex Ratio: 1.61) .Overall, 4152 cases (42.63%) were due to gastric cancer and 2112 cases (21.68%) were due to liver cancer.Total years of life lost due to premature death from gastrointestinal cancers during the 16-year study periodwas 73565 yr (2.33 per 1000 persons) in men, 52766 yr (1.71 per 1000 persons) in women, and 126331 yr (2.02per 1000 persons) in both sexes.  \nConclusion: Among all cancers, the highest mortality rates in both sexes belong to gastric cancer. This studyshowed the trend of YLL rate of malignant neoplasms of liver and intrahepatic bile ducts, esophagus, oralcavity, and colon cancer were increasing in both sexes, however, the trend of YLL rate for malignant neo -plasms ofthe small intestine was decreasing in both sexes. Variation of GI cancers patterns and trends aroundthe Fars Province indicated that a more comprehensive control plan is needed to control these variations.  \nKeywords: Gastrointestinal; Cancer; Years of life lost; Iran; Joinpoint regression  \nCopyright © 2024 Azarbakhsh et al. Published by Tehran University of Medical Sciences.  \nThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license.  \n(https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited  \n671 Available at: http://ijph.tums.ac.ir  \nAzarbakhsh et al.: The Trend of Years of Life Lost due to Gastrointestinal Cancers …  \n## Introduction\n\nCancer is one of the leading causes of death anddisability in the world. Gastrointestinal cancerscan cause major health problems globally sincetheir burden is increasing in many countries (1) .Gastric, esophageal, and colorectal cancers arethe most common gastrointestinal tract cancersand some of the leading causes of cancer-relateddeaths in the world (2) . Gastrointestinal cancersare estimated to be responsible for one-third ofall cases of dementia in developing countries (3) .Gastrointestinal cancers have poor prognosesdue to being asymptomatic in the early stages andbeing diagnosed in the advanced stages of thedisease(4","cbCaidBohJzAiL5W","https://ap.wps.com/l/cbCaidBohJzAiL5W","pdf",743363,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Material and Methods","[{\"question\":\"What period and population were analyzed in this study?\",\"answer\":\"The study analyzed deaths due to gastrointestinal cancers in Fars Province, southern Iran, during 2004–2019.\"},{\"question\":\"How were years of life lost (YLL) calculated?\",\"answer\":\"YLL was calculated using the YLL template of 2015 by the WHO.\"},{\"question\":\"What statistical approach was used to evaluate trends over time?\",\"answer\":\"Joinpoint regression based on a log-linear model was used to describe changing trends and the rate of increase or decrease across successive periods.\"}]","The Trend of Years of Life Lost due to Gastrointestinal Cancers in Fars (Iran) 2004-2019 | PDF",1789978854,23]