[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-427254-105":59,"doc-detail-427254-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-sleep-heart-brain-connection-sex-specific-modifiable-risk-factors-and-cognitive-impact-in-mid-to-late-life","THE SLEEP-HEART-BRAIN CONNECTION - Sex-specific modifiable risk factors and cognitive impact in mid-to-late life","","Poor sleep and cardiovascular health are modifiable risk factors for cognitive decline, yet their interaction with cognition—especially whether patterns differ by sex—remains insufficiently studied. This study assessed sex-specific interactive effects of sleep health and cardiovascular risk factors on cognition in mid-to-late life. Middle-aged and older adults (N=270) provided sleep measures (PSQI), medical history and demographics (including biological sex, BMI), substance use, and self-reported cognition (CFQ), with a subset performing objective cognitive tasks. Moderation analyses tested sex differences while controlling for age.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-sleep-heart-brain-connection-sex-specific-modifiable-risk-factors-and-cognitive-impact-in-mid-to-late-life/427254/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-sleep-heart-brain-connection-sex-specific-modifiable-risk-factors-and-cognitive-impact-in-mid-to-late-life/427254.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-20","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study’s main objective?","Question",{"text":112,"@type":113},"To evaluate sex-specific interactive patterns between sleep health, cardiovascular risk factors, and cognitive outcomes in mid-to-late life.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What measures were used to assess sleep health and cognition?",{"text":117,"@type":113},"Sleep health was assessed with the Pittsburgh Sleep Quality Index (PSQI), and cognition was evaluated using the Cognitive Failures Questionnaire plus objective tasks in a subset.",{"name":119,"@type":110,"acceptedAnswer":120},"How did sex influence the association between cardiovascular risk and attention?",{"text":121,"@type":113},"Sex moderated interactive associations between PSQI-Total, CVD risk score, and endogenous attentional orienting: the pattern was observed in men but not in women.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427254,1791191778,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Innovation in Aging, 2025, Vol. 9, No. S2 147  \nAbstract citation ID: igaf122.487  \nTHE SLEEP-HEART-BRAIN CONNECTION:  \nSEX-SPECIFIC MODIFIABLE RISK FACTORS AND  \nCOGNITIVE IMPACT IN MID-TO-LATE LIFE  \nAshley Curtis, Amy Costa, and Natasa Billeci, University of South Florida, Tampa, Florida, United States  \nPoor sleep and cardiovascular health are considered modifiable risk factors of cognitive decline. How these functions interact in associations with cognition, and whether there are sex differences in patterns of association remains underexplored. The present study evaluated sex-specific interactive patterns of sleep health and cardiovascular risk factors on cognition in mid-to-late life. Middle-aged and older adults (N = 270; 124 women; Mage=64.5±7.8) completed measures of sleep health [(Pittsburgh Sleep Quality Index (PSQI)], medical history and demographics (including biological sex, BMI), substance use (Alcohol Use Identification Test, smoking history), and self-reported cognition (Cognitive Failures Questionnaire) . A subset of participants (n = 67) completed objective cognitive tasks (Posner Cueing Task, Sternberg Working Memory Task, Stroop Task) . Moderation analyses examined sex differences in interactive associations between sleep health, cardiovascular disease (CVD) risk score (combined score including presence of hypertension, cancer, diabetes, smoking, hazardous alcohol use, overweight/obesity) and cognitive function, controlling for age. Sex moderated interactive associations between PSQI-Total, CVD risk score and endogenous attentional orienting. Specifically, in men, greater CVD risk  \nscore was associated with worse attentional orient∼ing only in  \nthose with worst global sleep quality (PSQI-Total 11; p=.02), and this pattern was not observed in women. Worse sleep health may exacerbate the impact of cardiovascular disease risk profile on objective spatial attention in mid-to-late life men. Sex-specific monitoring and tailoring of treatments for cardiovascular and sleep health is encouraged. Prospective studies that examine underlying mechanisms (e.g., circulating testosterone) are needed to understanding sex and sleep-specific interactive risk factors of cognitive decline.","cbCaiqEE3wii6INQ","https://ap.wps.com/l/cbCaiqEE3wii6INQ","pdf",196798,"English","# Abstract\n## Study aim and population\n## Measures and data collection\n## Moderation results by sex\n## Implications and future research","[{\"question\":\"What is the study’s main objective?\",\"answer\":\"To evaluate sex-specific interactive patterns between sleep health, cardiovascular risk factors, and cognitive outcomes in mid-to-late life.\"},{\"question\":\"What measures were used to assess sleep health and cognition?\",\"answer\":\"Sleep health was assessed with the Pittsburgh Sleep Quality Index (PSQI), and cognition was evaluated using the Cognitive Failures Questionnaire plus objective tasks in a subset.\"},{\"question\":\"How did sex influence the association between cardiovascular risk and attention?\",\"answer\":\"Sex moderated interactive associations between PSQI-Total, CVD risk score, and endogenous attentional orienting: the pattern was observed in men but not in women.\"}]","THE SLEEP-HEART-BRAIN CONNECTION - Sex-specific modifiable risk factors and cognitive impact in mid-to-late life | PDF",1790643326]