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The review highlights SPP1 on TAMs in lung adenocarcinoma as associated with poor prognosis and chemoresistance and proposes SPP1 as a marker for monocyte-derived protumor TAM subpopulations.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-significance-of-spp1-in-lung-cancers-and-its-impact-as-a-marker-for-protumor-tumor-associated-macrophages/383510/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-significance-of-spp1-in-lung-cancers-and-its-impact-as-a-marker-for-protumor-tumor-associated-macrophages/383510.png","ImageObject",300,407,{"name":42,"@type":43},"Oliver","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",16,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What role do tumor-associated macrophages (TAMs) play in lung cancer?","Question",{"text":63,"@type":64},"TAMs support protumor functions such as invasion, metastasis, and immunosuppression, and a higher TAM density is associated with a poor clinical course.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What is SPP1 (osteopontin) and why is it important in this review?",{"text":68,"@type":64},"SPP1 is a multifunctional secreted phosphorylated glycoprotein. Its expression has been linked to poor prognosis, and the review focuses on its significance in lung cancer via TAM biology.",{"name":70,"@type":61,"acceptedAnswer":71},"How is SPP1 related to chemoresistance in lung adenocarcinoma?",{"text":72,"@type":64},"SPP1 expression on TAMs is correlated with poor prognosis and chemoresistance in lung adenocarcinoma, and the SPP1/CD44 axis is discussed as a key mechanism for cell-to-cell communication between cancer cells and TAMs.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},383510,1790413291,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","cancers   \nReview  \nThe Significance of SPP1 in Lung Cancers and Its Impact as a Marker for Protumor Tumor-Associated Macrophages  \nEri Matsubara 1,2,†, Hiromu Yano 1,†, Cheng Pan 1, Yoshihiro Komohara 1,3, *, Yukio Fujiwara 1, Shukang Zhao 1,2, Yusuke Shinchi 2, Daisuke Kurotaki 4 and Makoto Suzuki 2, *  \nCitation: Matsubara, E.; Yano, H.; Pan, C.; Komohara, Y.; Fujiwara, Y.; Zhao, S.; Shinchi, Y.; Kurotaki, D.; Suzuki, M. The Significance of SPP1 in Lung Cancers and Its Impact asa Marker for Protumor  \nTumor-Associated Macrophages. Cancers 2023, 15, 2250. [https://](https://)[ ](https://)[doi.org/10.3390/cancers15082250](doi.org/10.3390/cancers15082250)  \nAcademic Editor: Noriaki Sunaga  \nReceived: 15 March 2023  \nRevised: 7 April 2023  \nAccepted: 10 April 2023  \nPublished: 12 April 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan  \n2 Department of Thoracic Surgery and Breast Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan  \n3 Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto 860-8556, Japan  \n4 Laboratory of Chromatin Organization in Immune Cell Development, International Research Center for Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan  \n* [Correspondence: ycomo@kumamoto-u.ac.jp](Correspondence: ycomo@kumamoto-u.ac.jp) (Y.K.); [smakoto@kumamoto-u.ac.jp](smakoto@kumamoto-u.ac.jp) (M.S.);  \nTel.: +81-96-373-5095 (Y.K.); +81-96-373-5533 (M.S.)† These authors contributed equally to this work.  \nSimple Summary: Macrophages that infiltrate the cancer microenvironment are referred to as tumor-associated macrophages (TAMs) . Phosphoprotein 1 (SPP1), also known as osteopontin, is amultifunctional secreted phosphorylated glycoprotein. In this review, we summarize the significance of TAMs in lung cancers and discuss the importance of SPP1 as a new marker for the protumor subpopulation of TAMs in lung adenocarcinoma. (1) The presence of TAMs is reportedly a poor prognostic factor in lung cancer. (2) We recently revealed that SPP1 expression on TAMs is correlated with poor prognosis and chemoresistance in lung adenocarcinoma. (3) SPP1 is a potentially useful marker for detecting monocyte-derived TAMs.  \nAbstract: Macrophages are a representative cell type in the tumor microenvironment. Macrophages that infiltrate the cancer microenvironment are referred to as tumor-associated macrophages (TAMs) . TAMs exhibit protumor functions related to invasion, metastasis, and immunosuppression, and an increased density of TAMs is associated with a poor clinical course in many cancers. Phosphoprotein 1 (SPP1), also known as osteopontin, is a multifunctional secreted phosphorylated glycoprotein. Although SPP1 is produced in a variety of organs, at the cellular level, it is expressed on only a few cell types, such as osteoblasts, fibroblasts, macrophages, dendritic cells, lymphoid cells, and mononuclear cells. SPP1 is also expressed by cancer cells, and previous studies have demonstrated correlations between levels of circulating SPP1 and/or increased SPP1 expression on tumor cells and poor prognosis in many types of cancer. We recently revealed that SPP1 expression on TAMsis correlated with poor prognosis and chemoresistance in lung adenocarcinoma. In this review, we summarize the significance of TAMs in lung cancers and discuss the importance of SPP1 as a new marker for the protumor subpopulation of monocyte-derived TAMs in lung adenocarcinoma. Several studies have shown that the SPP1/CD44 axis contribute to cancer chemoresistance in solid cancers, so","cbCaiuK5z9rpUbL6","https://ap.wps.com/l/cbCaiuK5z9rpUbL6","pdf",2075364,15,"English","# Introduction\n# Tumor Microenvironment and TAMs\n# SPP1/Osteopontin in Cancer\n# SPP1 as a Marker for Protumor TAMs\n# SPP1/CD44 Axis in Chemoresistance","[{\"question\":\"What role do tumor-associated macrophages (TAMs) play in lung cancer?\",\"answer\":\"TAMs support protumor functions such as invasion, metastasis, and immunosuppression, and a higher TAM density is associated with a poor clinical course.\"},{\"question\":\"What is SPP1 (osteopontin) and why is it important in this review?\",\"answer\":\"SPP1 is a multifunctional secreted phosphorylated glycoprotein. Its expression has been linked to poor prognosis, and the review focuses on its significance in lung cancer via TAM biology.\"},{\"question\":\"How is SPP1 related to chemoresistance in lung adenocarcinoma?\",\"answer\":\"SPP1 expression on TAMs is correlated with poor prognosis and chemoresistance in lung adenocarcinoma, and the SPP1/CD44 axis is discussed as a key mechanism for cell-to-cell communication between cancer cells and TAMs.\"}]","The Significance of SPP1 in Lung Cancers and Its Impact as a Marker for Protumor Tumor-Associated Macrophages | PDF",1790257417,38]