[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331703-105":59,"doc-detail-331703-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-significance-of-aldehyde-dehydrogenase-1-in-cancers","The Significance of Aldehyde Dehydrogenase 1 in Cancers","","The paper reviews how ALDH isozymes contribute to cancer biology, focusing on ALDH1 as an important factor in tumor initiation and progression. It summarizes research showing that ALDH is frequently overexpressed across diverse cancers and that distinct isoforms display cancer-specific expression patterns linked to patient prognosis. The review also connects ALDH1 to key cellular functions—metabolism, oxidative stress control, detoxification, and differentiation—while explaining mechanisms driving elevated ALDH expression during cancer development.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-significance-of-aldehyde-dehydrogenase-1-in-cancers/331703/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-significance-of-aldehyde-dehydrogenase-1-in-cancers/331703.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of this paper regarding ALDH and cancers?","Question",{"text":112,"@type":113},"The paper discusses the roles of ALDH isozymes in different cancers, reviews advances in ALDH1-targeting therapies, and examines mechanisms that explain why ALDH expression increases during cancer development.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does ALDH expression relate to cancer stem cells and differentiation?",{"text":117,"@type":113},"ALDH1 is highlighted as a cancer stem cell marker because it supports stemness and stem cell differentiation. The review connects ALDH activity to mechanisms that help explain how stem cells persist and how differentiation can become altered in tumors.",{"name":119,"@type":110,"acceptedAnswer":120},"Which cancers and clinical outcomes does the review connect to ALDH dysregulation?",{"text":121,"@type":113},"The review presents abnormal ALDH expression across multiple cancer types, including breast, colorectal, lung, gastric, cervical, melanoma, prostate, and renal cancer, and correlates these patterns with patient prognosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331703,1790196351,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1794309523707217728","Review  \nThe Significance of Aldehyde Dehydrogenase 1 in Cancers  \nAnh L. Nguyen 1,2, Caroline O. B. Facey 2 and Bruce M. Boman 1,2,3, *  \nAcademic Editors: Beata Želazowska-Rutkowska and Karolina Orywal  \nReceived: 14 November 2024  \nRevised: 16 December 2024  \nAccepted: 26 December 2024  \nPublished: 30 December 2024  \nCitation: Nguyen, A.L.; Facey,  \nC.O.B.; Boman, B.M. The Significance of Aldehyde Dehydrogenase 1 in Cancers. Int. J. Mol. Sci. 2025, 26, 251 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms26010251  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA; [nguyena@udel.edu](nguyena@udel.edu)  \n[2](2 Center for Translational Cancer Research)[ Center for Translational Cancer Research](2 Center for Translational Cancer Research), [Helen F](Helen F). Graham Cancer Center and Research Institute, 4701 Ogletown-Stanton Road, Newark, DE 19713, USA; [caroline.facey@christianacare.org](caroline.facey@christianacare.org)  \n3 Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA  \n* [Correspondence: brboman@udel.edu](Correspondence: brboman@udel.edu); Tel.: +1-267-303-9241  \nAbstract: The goal of this paper is to discuss the role of ALDH isozymes in different cancers, review advances in ALDH1-targeting cancer therapies, and explore a mechanism that explains how ALDH expression becomes elevated during cancer development. ALDHis often overexpressed in cancer, and each isoform has a unique expression pattern and a distinct role in different cancers. The abnormal expression of ALDHs in different cancer types (breast, colorectal, lung, gastric, cervical, melanoma, prostate, and renal) is presented and correlated with patient prognosis. ALDH plays a significant role in various cellular functions, such as metabolism, oxidative stress response, detoxification, and cellular differentiation. Among the ALDH families, ALDH1 has gained considerable attention as a cancer stem cell (CSC) marker due to its significant role in the maintenance of stemness and the differentiation of stem cells (SCs), along with its involvement in tumorigenesis. A description of the cellular mechanisms and physiology of ALDH1 that underlies cancer development is provided. Moreover, current advances in ALDH1-targeting cancer therapies are discussed.  \nKeywords: aldehyde dehydrogenase; ALDH isoenzymes; retinoic acid; cancer stem cells; colorectal cancer; breast cancer; lung cancer; gastric cancer; cervical cancer; melanoma; prostate cancer; renal cancer  \n1. Background Information  \nThe aim of this background is to discuss the function and superfamily structure of aldehyde dehydrogenase (ALDH) proteins in relation to cancer development, growth, and treatment. The ALDH group of genes functions as enzymes that catalyze the oxidation of endogenous and exogenous aldehyde substrates to carboxylic acids in certain life processes. In this paper, we start with a description of how ALDH function might be crucial to the development of cancer. We then provide a description of ALDH superfamilies, isoenzymes, protein structure, and cellular physiology. Finally, a deliberation on the role that ALDH1 plays in the development of breast, colorectal, lung, gastric, and other cancers is delivered. ALDH1A proteins play a key role in many biological processes, such as development, homeostasis, and tumorigenesis, through their enzymatic activity in retinoic acid (RA) signaling by converting retinal to RA (Figure 1) . This ALDH-based step in the RA pathway is important because RA signaling controls cellular differentiation. ","cbCaii3hdkND8hXg","https://ap.wps.com/l/cbCaii3hdkND8hXg","pdf",1265933,27,"English","# Background Information\n## ALDH superfamily structure and function in cancer\n## ALDH1 in retinoic acid (RA) signaling and differentiation\n## ALDEFLUOR and ALDH activity as a stem cell marker\n## Mechanistic feedback model linking CYP26A1, RA signaling, and stemness\n## Proposed role of ALDH1 in tumorigenesis","[{\"question\":\"What is the main purpose of this paper regarding ALDH and cancers?\",\"answer\":\"The paper discusses the roles of ALDH isozymes in different cancers, reviews advances in ALDH1-targeting therapies, and examines mechanisms that explain why ALDH expression increases during cancer development.\"},{\"question\":\"How does ALDH expression relate to cancer stem cells and differentiation?\",\"answer\":\"ALDH1 is highlighted as a cancer stem cell marker because it supports stemness and stem cell differentiation. The review connects ALDH activity to mechanisms that help explain how stem cells persist and how differentiation can become altered in tumors.\"},{\"question\":\"Which cancers and clinical outcomes does the review connect to ALDH dysregulation?\",\"answer\":\"The review presents abnormal ALDH expression across multiple cancer types, including breast, colorectal, lung, gastric, cervical, melanoma, prostate, and renal cancer, and correlates these patterns with patient prognosis.\"}]","The Significance of Aldehyde Dehydrogenase 1 in Cancers | PDF",1789994772,68]