[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-342662-105":59,"doc-detail-342662-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-senescence-journey-in-cancer-immunoediting","The senescence journey in cancer immunoediting","","Cancer progression is continuously shaped by immune activity that can destroy emerging tumor cells or constrain metastatic spread, yet dysregulated immune function in the tumor microenvironment can also accelerate growth through cancer immunoediting. This process is organized into three phases—elimination, equilibrium, and escape—and depends on multiple cancer- and microenvironment-specific factors. Cellular senescence is a durable cell-cycle arrest program driven by pathophysiological stimuli and sustained by secreted bioactive, inflammatory mediators, acting as a potent immunomodulator that can support both immunosurveillance and immunosuppression. In this review, the authors analyze context- and timing-dependent senescence effects across all three phases, including roles in immune-cell recruitment, immune escape, tumor dormancy, and therapy resistance, with the goal of clarifying therapeutic implications of senescence modulation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-senescence-journey-in-cancer-immunoediting/342662/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-senescence-journey-in-cancer-immunoediting/342662.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is cancer immunoediting and what are its phases?","Question",{"text":112,"@type":113},"Cancer immunoediting is a process through which the immune system shapes tumor development. 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Molecular Cancer (2024) 23:68 [https://doi.org/10.1186/s12943-024-01973-5](https://doi.org/10.1186/s12943-024-01973-5)  \nMolecular Cancer  \nREVIEW Open Access  \nThe senescence journey in cancer immunoediting  \nAlessandra Zingoni 1, Fabrizio Antonangeli2, Silvano Sozzani 1, Angela Santoni 1,3, Marco Cippitelli 1* and Alessandra Soriani 1*  \nAbstract  \nCancer progression is continuously controlled by the immune system which can identify and destroy nascent tumor cells or inhibit metastatic spreading. However, the immune system and its deregulated activity in the tumor microenvironment can also promote tumor progression favoring the outgrowth of cancers capable of escaping immune control, in a process termed cancer immunoediting. This process, which has been classified into three phases, i. e.“elimination”,“equilibrium” and “escape”, is influenced by several cancer-and microenvironmentdependent factors. Senescence is a cellular program primed by cells in response to different pathophysiological stimuli, which is based on long-lasting cell cycle arrest and the secretion of numerous bioactive and inflammatory molecules. Because of this, cellular senescence is a potent immunomodulatory factor promptly recruiting immune cells and actively promoting tissue remodeling. In the context of cancer, these functions can lead to both cancer immunosurveillance and immunosuppression. In this review, the authors will discuss the role of senescence in cancer immunoediting, highlighting its context-and timing-dependent effects on the different three phases, describing how senescent cells promote immune cell recruitment for cancer cell elimination or sustain tumor microenvironment inflammation for immune escape. A potential contribution of senescent cells in cancer dormancy, as a mechanism of therapy resistance and cancer relapse, will be discussed with the final objective to unravel the immunotherapeutic implications of senescence modulation in cancer.  \nKeywords Cancer, Senescence, SASP, Immunoediting, Immunosurveillance, Dormancy, Senotherapy  \n*Correspondence: Marco Cippitelli  \nmarco.cippitelli@uniroma1.it Alessandra Soriani [alessandra.soriani@uniroma1.it](alessandra.soriani@uniroma1.it)  \n1Department of Molecular Medicine, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome 00161, Italy  \n2Institute of Molecular Biology and Pathology, National Research Council (CNR), Rome 00185, Italy  \n3IRCCS Neuromed, Pozzilli 86077, Italy  \nBackground  \nThere are several factors influencing tumor progression, including genetic alterations, epigenetic modifications, oncogenic signals, and inflammatory cytokines. Among these, the contribution of the immune response on cancer cell fate is crucial, playing a dual role potentially limiting or, paradoxically, promoting tumor growth [1, 2].  \nIn 1909, Paul Ehrlich postulated the concept that the immune system can recognize and eliminate cancer cells (Ned Tijdschr Geneeskd. 1909;5:273–290) and in the late 1950s Burnet and Thomas further expanded this concept with the immunosurveillance theory of cancer, hypothesizing that lymphocytes act as sentinels capable of recognizing and eliminating nascent tumor cells before they  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need","cbCaivndurshRhP6","https://ap.wps.com/l/cbCaivndurshRhP6","pdf",3625441,21,"English","# Abstract\n# Background\n## Immune control of cancer progression\n## Cancer immunosurveillance and cancer immunoediting\n# Cellular senescence and its link to aging and cancer\n# Licensing and reuse terms","[{\"question\":\"What is cancer immunoediting and what are its phases?\",\"answer\":\"Cancer immunoediting is a process through which the immune system shapes tumor development. It is classified into three phases: elimination, equilibrium, and escape.\"},{\"question\":\"How does cellular senescence influence cancer immunoediting?\",\"answer\":\"Cellular senescence is a program involving long-lasting cell-cycle arrest and secretion of bioactive inflammatory molecules. In cancer, it can drive immune-cell recruitment that supports elimination, while also sustaining inflammation that favors immune escape.\"},{\"question\":\"Why is senescence modulation relevant to therapy resistance and cancer relapse?\",\"answer\":\"The review discusses senescent cells as a potential contributor to cancer dormancy, which can be linked to therapy resistance and relapse, suggesting immunotherapeutic implications of targeting senescence.\"}]","The senescence journey in cancer immunoediting | PDF",1790047614,53]