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Survival comparisons showed no significant differences by orbital invasion grade, while definitive tumor resection with orbit preservation significantly extended disease-free survival versus non-definitive approaches.",{"@graph":14,"@context":77},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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was the main objective of this study?","Question",{"text":63,"@type":64},"To assess prognosis of sinonasal SqCC with orbital invasion from various perspectives, including outcomes related to treatment strategy and invasion extent.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were patients selected for the analysis?",{"text":68,"@type":64},"Patients with primary sinonasal SqCC invading the orbit treated at Seoul National University Hospital and Seoul National University Bundang Hospital between 2009 and 2018 were reviewed retrospectively.",{"name":70,"@type":61,"acceptedAnswer":71},"What treatment approach showed improved outcomes for disease-free survival?",{"text":72,"@type":64},"When definitive treatment used tumor resection with orbit preservation, disease-free survival was significantly extended compared with cases where surgery was not the definitive treatment (RT or CCRT).",{"name":74,"@type":61,"acceptedAnswer":75},"Did the study find differences in outcomes across grades of orbital invasion?",{"text":76,"@type":64},"Overall survival and disease-free survival showed no significant differences based on the grade of orbital invasion.","https://schema.org",{"og:url":32,"og:type":79,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":81,"canonical":32},"index,follow",{"doc_id":83,"site_id":7},332427,1790215966,{"code":4,"msg":86,"data":87},"success",[88,92,96,100,105,110,115,118,123,126,130],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Story & 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[https://doi.org/10.21053/ceo.2024.00157](https://doi.org/10.21053/ceo.2024.00157)  \npISSN 1976-8710 eISSN 2005-0720  \nOriginal Article  \nThe Search for an Ideal Definitive Treatment of Sinonasal Squamous Cell Carcinoma With Orbit  \nInvasion  \nSeung Cheol Han1,2  ·Jeon Seong2  ·Sung-Woo Cho3  ·Hyun-Jik Kim2  ·Jeong-Whun Kim3  Dong-Young Kim2  ·Chae-Seo Rhee2,3  ·Tae-Bin Won2,3   \n1Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University Sejong Hospital, Sejong, Korea 2Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital,  \nSeoul National University College of Medicine, Seoul, Korea  \n3Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Korea  \nObjectives. Sinonasal squamous cell carcinoma (SqCC) often invades the orbit. The treatment approach for sinonasal cancer that has spread to the orbit varies across medical centers and depends on the extent of the invasion.The decision to preserve the orbit in the treatment strategy is made on a case-by-case basis and results in varying outcomes. Currently, a multimodal treatment regimen, which may include surgery, chemotherapy, radiotherapy (RT), or concurrent chemoradiotherapy (CCRT), is commonly adopted for managing sinonasal cancers.This study aims to assess the prognosis of sinonasal SqCC with orbital invasion from various perspectives.  \nMethods. We conducted a retrospective review of patients with primary sinonasal SqCC invading the orbit who were treated at Seoul National University Hospital and Seoul National University Bundang Hospital between 2009 and 2018. The extent of the tumor, orbital invasion, treatment strategies, recurrence rates, and survival rates were analyzed.  \nResults. Overall survival and disease-free survival (DFS) rates showed no significant differences based on the grade of orbital invasion.When tumor resection with orbit preservation was employed as the definitive treatment, DFS was significantly extended compared to cases where surgery was not the definitive treatment (RT or CCRT). Additionally, there was no significant difference in DFS between patients who underwent orbit exenteration and those who underwent tumor resection with orbit preservation as the definitive treatment.  \nConclusion. Tumor resection with orbit preservation as the definitive treatment appears to be the preferred approach, prolonging DFS and increasing the likelihood of longer-term survival in cases of SqCC with orbital invasion.  \nKeywords. Nasal Cancers; Survival Analysis; Disease-Free Survival; Mortality  \nINTRODUCTION  \nSinonasal cancer is a rare malignant tumor, accounting for about 3% of head and neck tumors [1,2]. The most common patholo-  \n• Received June 6, 2024 Revised July 22, 2024 Accepted July 29, 2024  \n• Corresponding author: Tae-BinWon  \nDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea  \nTel: +82-2-2072-4037, Fax: +82-2-745-2387  \n[Email: binent@hanmail.net](Email: binent@hanmail.net)  \ngy associated with sinonasal cancer is squamous cell carcinoma (SqCC) [1,3]. This cancer is often diagnosed at advanced stages because it can remain asymptomatic until the tumor invades or approaches critical areas such as the skull base, nerves, orbit, or palate [4]. Historically, the standard treatment for sinonasal cancer involved en-bloc resection of the primary tumor. However, this method can be highly invasive and may lead to unfavorable cosmetic outcomes. In cases of orbital invasion, en-bloc resection might require orbit exenteration (OE), which significantly affects a patient’s quality of life. As a result, radiotherapy (RT) and concurrent chemoradiotherapy (CCRT) have become alternative treatment options and are used in selected cases [5","cbCaintDsuo1Lj1W","https://ap.wps.com/l/cbCaintDsuo1Lj1W","pdf",864549,"English","# Objectives\n# Methods\n# Results\n# Conclusion\n# Keywords","[{\"question\":\"What was the main objective of this study?\",\"answer\":\"To assess prognosis of sinonasal SqCC with orbital invasion from various perspectives, including outcomes related to treatment strategy and invasion extent.\"},{\"question\":\"How were patients selected for the analysis?\",\"answer\":\"Patients with primary sinonasal SqCC invading the orbit treated at Seoul National University Hospital and Seoul National University Bundang Hospital between 2009 and 2018 were reviewed retrospectively.\"},{\"question\":\"What treatment approach showed improved outcomes for disease-free survival?\",\"answer\":\"When definitive treatment used tumor resection with orbit preservation, disease-free survival was significantly extended compared with cases where surgery was not the definitive treatment (RT or CCRT).\"},{\"question\":\"Did the study find differences in outcomes across grades of orbital invasion?\",\"answer\":\"Overall survival and disease-free survival showed no significant differences based on the grade of orbital invasion.\"}]","The Search for an Ideal Definitive Treatment of Sinonasal Squamous Cell Carcinoma With Orbit Invasion | PDF",1789998147,25]