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Twenty-four trials were included. CKI improved complete and partial remission and enhanced quality of life and performance status. It also reduced lung-cancer pain, increased immunity, and alleviated adverse reactions.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-safety-and-efficacy-of-compound-kushen-injection-with-chemoradiotherapy-for-the-outcomes-of-lung-and-gastrointestinal-cancers-a-primsa-compliant-meta-analysis/330389/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-safety-and-efficacy-of-compound-kushen-injection-with-chemoradiotherapy-for-the-outcomes-of-lung-and-gastrointestinal-cancers-a-primsa-compliant-meta-analysis/330389.png","ImageObject",300,407,{"name":42,"@type":43},"Olivia Brown","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is Compound Kushen Injection (CKI) and what cancers does it target in this study?","Question",{"text":63,"@type":64},"CKI is a mixture of natural compounds extracted from Radix Sophorae and Smilax glabra. It is evaluated as an antitumor preparation for lung and gastrointestinal cancers.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the meta-analysis conducted and what sources were searched?",{"text":68,"@type":64},"Electronic databases including CNKI, Wanfang, PubMed, EMBASE, and Web of Science were searched. Included studies were evaluated using the Cochrane Handbook and meta-analyses were performed with RevMan 5.3.",{"name":70,"@type":61,"acceptedAnswer":71},"What benefits did CKI adjuvant therapy show when combined with chemoradiotherapy?",{"text":72,"@type":64},"The combination improved complete remission and partial response, and showed advantages in quality of life and performance status. It also reduced pain in lung-cancer patients, increased immunity levels, and alleviated adverse reactions.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},330389,1790463120,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":113},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","®  \nSystematic Review and Meta-Analysis   \nThe safety and efficacy of Compound Kushen Injection with chemoradiotherapy for the outcomes of lung and gastrointestinal cancers A PRIMSA-compliant meta-analysis  \nYing Chena , Mingyue Ma, PhDb , Feng Xuc ,*  \n\n| Abstract\u003Cbr>Background: Compound Kushen injection (CKI) is a mixture of natural compounds extracted from Radix Sophorae and Smilax glabra Roxb. CKI, as an antitumor preparation, plays a vital role in the clinical treatment of lung and gastrointestinal cancers. Methods: Electronic databases such as the China National Knowledge Infrastructure, Wanfang data, PubMed, EMBASE, and Web of Science were searched for studies. The included studies were evaluated according to the Cochrane Handbook for Systematic Reviews, and meta-analyses were performed using RevMan 5.3 software.\u003Cbr>Results: Twenty-four randomized controlled trials were selected for meta-analysis. The outcomes showed that CKI adjuvant therapy significantly improved complete remission (CR) and partial response (PR) compared to patients without CKI treatment in gastrointestinal cancers (CR: odds ratio [OR] = 1.76, 95% confidence interval [CI]: [1 .29, 2.41], P = .0004; PR: OR = 1.64, 95% CI: [1 .29, 2.07], P = .0001), and lung cancer (CR: OR = 2. 18, 95% CI: [1 .36, 3.51], P = .001); PR: OR = 1.81, 95% CI: [1 .31, 2.50], P = .0003) . CKI adjuvant therapy had a statistically significant advantage in optimizing life and health status (quality of life [QOL] for gastrointestinal cancers: MD = 1.76, 95% CI: [6 .41, 13.80], P = .001, and Karnofsky performance status [KPS] for gastrointestinal cancers: MD = 4.64, 95% CI: [2 .72, 6.57], P = .001; KPS for lung cancer: MD = 6.24, 95% CI [1 .78, 10.71], P =.006) . CKI reduced the pain in lung cancer patients (MD = −1 .76, 95% CI: [−1 .94, −1 .58], P \u003C .00001), increased immunity level (MD = 2.51, 95% CI: [2 . 17, 2.85], P \u003C .00001), and alleviated the adverse reactions for lung and gastrointestinal cancers (MD = 0.38, 95% CI: (0 .32, 0.46); P \u003C .00001) .\u003Cbr>Conclusion: The combination of CKI and chemoradiotherapy for treating lung and gastrointestinal cancer has positive effects on short-term and long-term outcomes and has advantages over chemoradiotherapy alone regarding safety and efficacy. Abbreviations: CI = confidence interval, CKI = Compound Kushen Injection, CR = complete remission, KPS = Karnofsky Performance Status Scale, OR = odds ratio, OS = overall survival, PFS = progression-free survival, PR = partial remission, QOL = quality of life, VAS = visual analog scale. |\n| --- |\n| Keywords: chemoradiotherapy, Compound Kushen Injection, gastrointestinal cancer, lung cancer, meta-analysis |\n\n1. Introduction  \nGlobal cancer epidemiological data show 19.29 million cancer cases were diagnosed in 2020, with China accounting for 4.57 million (about 23.7%) of all new cases.[1] Major cancers associated with mortality and increased socioeconomic burden in China are lung, liver, stomach, colorectal, and esophageal cancers.[2] Surgical resection is currently the only means of radical treatment; however, many patients are not eligible due to  \nsystemic co-morbidities. Nonsurgical therapy, including chemotherapy and radiation, is also available for patients with lung and gastrointestinal cancers. Although these have beneficial effects, they are associated with adverse reactions, including bone marrow suppression, gastrointestinal reactions, and liver damage. Thus, there is an urgent need to develop comprehensive and effective treatment strategies.  \nThe Compound Kushen Injection (CKI) is a mixture of natural compounds extracted from Radix Sophorae and Smilax  \nThis research was financially supported by Ningbo Clinical Medicine Research Center Project (grant no. 2019A21003).  \nThe authors have no conflicts of interest to disclose.  \nAll data generated or analyzed during this study are included in this published article [and its supplementary information files].  \na Department of Pharmacy, Ji","cbCaik8xlhCcpRcg","https://ap.wps.com/l/cbCaik8xlhCcpRcg","pdf",2827394,12,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Epidemiology and treatment needs\n## Compound Kushen Injection (CKI)","[{\"question\":\"What is Compound Kushen Injection (CKI) and what cancers does it target in this study?\",\"answer\":\"CKI is a mixture of natural compounds extracted from Radix Sophorae and Smilax glabra. It is evaluated as an antitumor preparation for lung and gastrointestinal cancers.\"},{\"question\":\"How was the meta-analysis conducted and what sources were searched?\",\"answer\":\"Electronic databases including CNKI, Wanfang, PubMed, EMBASE, and Web of Science were searched. Included studies were evaluated using the Cochrane Handbook and meta-analyses were performed with RevMan 5.3.\"},{\"question\":\"What benefits did CKI adjuvant therapy show when combined with chemoradiotherapy?\",\"answer\":\"The combination improved complete remission and partial response, and showed advantages in quality of life and performance status. It also reduced pain in lung-cancer patients, increased immunity levels, and alleviated adverse reactions.\"}]","The safety and efficacy of Compound Kushen Injection with chemoradiotherapy for the outcomes of lung and gastrointestinal cancers - A PRIMSA-compliant meta-analysis | PDF",1789988602]