[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331164-105":59,"doc-detail-331164-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-roles-of-tertiary-lymphoid-structures-in-genitourinary-cancers-molecular-mechanisms-therapeutic-strategies-and-clinical-applications","The roles of tertiary lymphoid structures in genitourinary cancers - molecular mechanisms, therapeutic strategies, and clinical applications","","Tertiary lymphoid structures (TLSs) are linked to distinct treatment responses and clinical prognosis across multiple cancer types, yet their mechanistic and clinical roles in genitourinary (GU) cancers remain insufficiently clarified. This review synthesizes TLS drivers of formation, structural basis, cellular composition, maturation stages, molecular characteristics, and specific functions in tumor-specific immunity. It also examines evidence on therapies targeting TLSs and explains how understanding TLS molecular and phenotypic heterogeneity can guide optimized immunotherapy strategies and maximize clinical benefit for GU cancers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-roles-of-tertiary-lymphoid-structures-in-genitourinary-cancers-molecular-mechanisms-therapeutic-strategies-and-clinical-applications/331164/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-roles-of-tertiary-lymphoid-structures-in-genitourinary-cancers-molecular-mechanisms-therapeutic-strategies-and-clinical-applications/331164.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are tertiary lymphoid structures (TLSs) and where do they typically occur?","Question",{"text":112,"@type":113},"TLSs are organized immune cell aggregates that usually form in non-lymphoid tissues with persistent chronic inflammation, such as autoimmune disease, chronic infection, and cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why are TLSs considered potentially important in genitourinary (GU) cancers?",{"text":117,"@type":113},"TLS presence in tumor lesions has been associated with clinical prognosis and survival outcomes, suggesting prognostic and predictive value tied to their role in tumor microenvironment–mediated antitumor immunity.",{"name":119,"@type":110,"acceptedAnswer":120},"What does the review emphasize about therapeutic strategies targeting TLSs?",{"text":121,"@type":113},"The review highlights emerging approaches that target TLSs and argues that TLS-targeted therapies should consider molecular and phenotypic heterogeneity and be applied in a context-dependent manner to suit different tumor microenvironments.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331164,1790146015,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","’Review Article  \nThe roles of tertiary lymphoid structures in  \ngenitourinary cancers: molecular mechanisms, therapeutic strategies, and clinical applications  \nJie Yang, MM, Xingyu Xiong, MD, Weitao Zheng, MD, Hang Xu, MD, Xinyang Liao, MD, Qiang Wei, MD*, Lu Yang, MD,PhD*  \nAbstract  \nThe presence of tertiary lymphoid structures (TLSs) associated with distinct treatment efficacy and clinical prognosis has been identified in various cancer types. However, the mechanistic roles and clinical implications of TLSs in genitourinary (GU) cancers remain incompletely explored. Despite their potential role as predictive markers described in numerous studies, it is essential to comprehensively evaluate the characteristics of TLSs, including drivers of formation, structural foundation, cellular compositions, maturation stages, molecular features, and specific functionality to maximize their positive impacts on tumor-specific immunity. The unique contributions of these structures to cancer progression and biology have fueled interest in these structures as mediators of antitumor immunity. Emerging data are trying to explore the effects of therapeutic interventions targeting TLSs. Therefore, a better understanding of the molecular and phenotypic heterogeneity of TLSs may facilitate the development of TLSs-targeting therapeutic strategies to obtain optimal clinical benefits for GU cancers in the setting of immunotherapy. In this review, the authors focus on the phenotypic and functional heterogeneity of TLSs in cancer progression, current therapeutic interventions targeting TLSs and the clinical implications and therapeutic potential of TLSs in GU cancers.  \nKeywords: antitumor immunity, genitourinary cancer, immune checkpoint blockade, tertiary lymphoid structures, tumor immune microenvironment  \nIntroduction  \nWith the development of current society and the expansion of the aging global population, the morbidity of age-related diseases, such as cardiovascular disease, chronic infection, and cancer is dramatically increasing due to the elevated mean global life expectancy[1] . According to the data from the International Agency for Research on Cancer, it is estimated that the number of newly diagnosed genitourinary (GU) cancers originating from the  \nDepartment of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People ’s Republic of China  \nJie Yang, Xingyu Xiong, Weitao Zheng, and Hang Xu contributed equally as the first author.  \nSponsorships or competing interests that maybe relevant to content are disclosed atthe end of this article.  \n*Corresponding authors. Address: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan. People’s Republic of China. Tel.: +[86 028 8542 2444. E-mail: wq933@hotmail.com](86 028 8542 2444. E-mail: wq933@hotmail.com) (Q. Wei);  \nTel.: +86 028 8542 2451. E-mail: wyclefl[ue@scu.edu.cn](ue@scu.edu.cn) (L. Yang).  \nCopyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.  \nInternational Journal of Surgery (2024) 110:5007–5021  \nReceived 14 March 2024; Accepted 30 June 2024  \nPublished online 5 July 2024  \n[http://dx.doi.org/10.1097/JS9.0000000000001939](http://dx.doi.org/10.1097/JS9.0000000000001939)  \nHIGHLIGHTS  \n• Deeper understandings on the biological functions and molecular mechanisms of tertiary lymphoid structures (TLSs) facilitate the advance of opening new avenues for targeted-therapy of cancer.  \n• Exploring potential factors contributing to the phenotypic and functional heterogeneity of TLSs will be promising to maximize their value as prognostic and predictive ","cbCaij3ABNOQ5zzA","https://ap.wps.com/l/cbCaij3ABNOQ5zzA","pdf",847850,15,"English","# Abstract\n# Introduction\n## TME and TLSs in GU cancer progression\n## Definitions and formation context of TLSs","[{\"question\":\"What are tertiary lymphoid structures (TLSs) and where do they typically occur?\",\"answer\":\"TLSs are organized immune cell aggregates that usually form in non-lymphoid tissues with persistent chronic inflammation, such as autoimmune disease, chronic infection, and cancer.\"},{\"question\":\"Why are TLSs considered potentially important in genitourinary (GU) cancers?\",\"answer\":\"TLS presence in tumor lesions has been associated with clinical prognosis and survival outcomes, suggesting prognostic and predictive value tied to their role in tumor microenvironment–mediated antitumor immunity.\"},{\"question\":\"What does the review emphasize about therapeutic strategies targeting TLSs?\",\"answer\":\"The review highlights emerging approaches that target TLSs and argues that TLS-targeted therapies should consider molecular and phenotypic heterogeneity and be applied in a context-dependent manner to suit different tumor microenvironments.\"}]","The roles of tertiary lymphoid structures in genitourinary cancers - molecular mechanisms, therapeutic strategies, and clinical applications | PDF",1789991988,38]