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Wheatgrass is a supplement rich in vitamins, minerals, and antioxidants, with reported roles in cardiovascular and liver health, diabetes, and inflammatory bowel conditions, and it has been investigated across several cancers. For colorectal cancer, evidence suggests possible anti-inflammatory, antioxidant, and anticancer actions, potentially as an adjunct therapy, but available data remain limited. This review compiles current evidence, outlines inflammatory pathways potentially involved, and highlights key future research needs.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-wheatgrass-in-colorectal-cancer-a-review-of-the-current-evidence-research-summary/332091/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-wheatgrass-in-colorectal-cancer-a-review-of-the-current-evidence-research-summary/332091.png","ImageObject",300,407,{"name":92,"@type":93},"Eliana","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What motivates studying wheatgrass in colorectal cancer?","Question",{"text":112,"@type":113},"CRC therapies can cause toxic effects and chemoresistance, creating a need for dietary interventions targeting immune and inflammatory processes. The review highlights wheatgrass’s anti-inflammatory and antioxidant potential and the currently limited but growing evidence in CRC.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What does the review cover regarding wheatgrass’s mechanisms?",{"text":117,"@type":113},"It compiles available evidence linking wheatgrass to colorectal cancer and describes possible roles in inflammatory pathways. It also considers wheatgrass’s potential anticarcinogenic properties and adjunctive use.",{"name":119,"@type":110,"acceptedAnswer":120},"How were studies selected for this review?",{"text":121,"@type":113},"Data were collected from MEDLINE, PubMed, Embase, and Web of Science published before December 2023. Search terms included “colorectal cancer”, “colon cancer”, “wheatgrass”, and “T. aestivum”, and only English-language articles were included.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332091,1790158582,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","Review  \nThe Role of Wheatgrass in Colorectal Cancer: A Review of the Current Evidence  \nMagie Tamraz 1, Najib Al Ghossaini 2 and Sally Temraz 3, *  \nCitation: Tamraz, M.; Al Ghossaini, N.; Temraz, S. The Role of Wheatgrass in Colorectal Cancer: AReview of the Current Evidence. Int.  \nJ. Mol. Sci. 2024, 25, 5166. [https://](https://)[ ](https://)[doi.org/10.3390/ijms25105166](doi.org/10.3390/ijms25105166)  \nAcademic Editor: Evgeny Imyanitov  \nReceived: 23 March 2024  \nRevised: 23 April 2024  \nAccepted: 2 May 2024  \nPublished: 9 May 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Nutrition and Public Health, Holy Spirit University of Kaslik, Jounieh P.O. BOX 446, Mount Lebanon, Lebanon; [magietamraz@gmail.com](magietamraz@gmail.com)  \n2 Department of Internal Medicine, Ain Wazein Medical Village,  \nChouf P.O. Box 1503-210/02, Mount Lebanon, Lebanon; [najibaal@hotmail.com](najibaal@hotmail.com)  \n3 Department of Internal Medicine, Oncology/Hematology Division, American University of Beirut Medical Center, Riad El Solh, Beirut 1107 2020, Lebanon  \n* Correspondence: [st29@aub.edu.lb](st29@aub.edu.lb); Tel.: +961-370000  \nAbstract: The etiology of colon cancer is either genetic in nature or results from inflammatory bowel diseases such as ulcerative colitis and Crohn's disease; nevertheless, dietary habits play a crucial role in the disease. Wheatgrass is a dietary supplement that is rich in vitamins, minerals, and antioxidants which contribute to health promotion in cardiovascular diseases, liver disease, blood diseases, diabetes, and inflammatory bowel diseases, as well as in several types of cancers, such as oral squamous cell cancer, cervical cancer, and breast cancer. In colorectal cancer (CRC), the prospect that wheatgrass possesses anti-inflammatory, antioxidant, and anticancer properties, and its use asan adjunctive therapy, have been minimally investigated and evidence is still limited. In this review, we compiled the available evidence pertaining to wheatgrass and its likely impact on CRC, described the pathways of inflammation in which wheatgrass could possibly play a role, and identified future research needs on the subject.  \nKeywords: chemotherapy; colorectal cancer; extracellular vesicles; inflammation; Triticum aestivum; wheatgrass  \n1. Introduction  \nColorectal cancer (CRC) is a major health concern because it ranks second in mortality among cancers worldwide [1] . The prevalence of CRC is predicted to reach up to 3.2 million new cases and 1.6 million deaths by 2040, with the majority of new cases (81%) taking place in high-income nations [1] . Heredity, genetic predisposition, food mutagens, and chronic inflammation have been implicated as possible risk factors for CRC development [2,3] . Moreover, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are associated with CRC development [4] .  \nCurrently, the treatment strategies for CRC include surgical resection, chemotherapy, and radiotherapy. However, these therapies are often accompanied by adverse toxic effects, chemoresistance, and off-target effects. Thus, there is an urgent need for dietary interventions that target the immune system, control inflammatory processes, and mitigate the adverse effects of chemotherapy. Nutraceuticals, which is a term derived from the words “nutrition” and “pharmaceuticals”, have been shown to exert their effects on the proliferation, metastasis, apoptosis, autophagy, and angiogenesis pathways in CRC [5] . Nutraceuticals include a wide range of dietary supplements, secondary plant metabolites, medicinal herbs, and microorganisms [6] . They control DNA-damaging factors in cancer cell","cbCaivPjbvaYO6AT","https://ap.wps.com/l/cbCaivPjbvaYO6AT","pdf",982622,14,"English","# Introduction\n## Colorectal cancer burden and risk factors\n## Nutraceuticals and dietary interventions in CRC\n# Wheatgrass and study rationale\n# Methods\n## Literature sources and search strategy","[{\"question\":\"What motivates studying wheatgrass in colorectal cancer?\",\"answer\":\"CRC therapies can cause toxic effects and chemoresistance, creating a need for dietary interventions targeting immune and inflammatory processes. The review highlights wheatgrass’s anti-inflammatory and antioxidant potential and the currently limited but growing evidence in CRC.\"},{\"question\":\"What does the review cover regarding wheatgrass’s mechanisms?\",\"answer\":\"It compiles available evidence linking wheatgrass to colorectal cancer and describes possible roles in inflammatory pathways. It also considers wheatgrass’s potential anticarcinogenic properties and adjunctive use.\"},{\"question\":\"How were studies selected for this review?\",\"answer\":\"Data were collected from MEDLINE, PubMed, Embase, and Web of Science published before December 2023. Search terms included “colorectal cancer”, “colon cancer”, “wheatgrass”, and “T. aestivum”, and only English-language articles were included.\"}]","The Role of Wheatgrass in Colorectal Cancer: A Review of the Current Evidence - Research Summary | PDF",1789996701,35]