[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-326787-105":59,"doc-detail-326787-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-role-of-trpm7-in-oncogenesis-review","The Role of TRPM7 in Oncogenesis - review","","This review summarizes current understanding of the roles of transient receptor potential melastatin-subfamily member 7 (TRPM7) channels in the pathophysiology of neoplastic diseases. It highlights TRPM family diversity within the TRP superfamily and emphasizes TRPM7’s combined channel and kinase (chanzyme) activity. Evidence links TRPM7 to tumorigenesis and major cancer hallmarks including proliferation, migration, invasion, and metastasis. The review surveys potential involvement across multiple malignancies and proposes TRPM7 as a promising therapeutic target.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-trpm7-in-oncogenesis-review/326787/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-trpm7-in-oncogenesis-review/326787.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does TRPM7 play in cancer-related processes?","Question",{"text":112,"@type":113},"TRPM7 chanzyme activity is linked to tumorigenesis and several hallmarks of cancer, including proliferation, migration, invasion, and metastasis. Increased expression and/or function of TRPM7 is reported across most malignant tumor types.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is TRPM7 different from other TRP family members?",{"text":117,"@type":113},"TRPM7 is unique in having kinase activity in addition to its channel function. The review also notes TRPM2 and TRPM6 as related proteins with similar combined characteristics.",{"name":119,"@type":110,"acceptedAnswer":120},"Which types of cancers are discussed regarding TRPM7 involvement?",{"text":121,"@type":113},"The review provides an overview across many malignancies, including nervous system tumors, head and neck cancers, upper gastrointestinal neoplasms, colorectal carcinoma, lung cancer, urinary system cancers, breast cancer, female reproductive organ tumors, prostate cancer, and other neoplastic pathologies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},326787,1790917198,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","Review  \nThe Role of TRPM7 in Oncogenesis  \nLászló Köles 1,2, Polett Ribiczey 1,2, Andrea Szebeni 1, Kristóf Kádár 1, Tibor Zelles 1,2,3 and Ákos Zsembery 1, *  \nCitation: Köles, L.; Ribiczey, P.; Szebeni, A.; Kádár, K.; Zelles, T.; Zsembery, Á . The Role of TRPM7 in Oncogenesis. Int. J. Mol. Sci. 2024, 25, 719. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms25020719  \nAcademic Editor: Pietro Campiglia  \nReceived: 28 November 2023  \nRevised: 30 December 2023  \nAccepted: 3 January 2024  \nPublished: 5 January 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary; [koles.laszlo@dent.semmelweis-univ.hu](koles.laszlo@dent.semmelweis-univ.hu) (L.K.); [aszebeni@gmail.com](aszebeni@gmail.com) (A.S.); [kadar.kristof@dent.semmelweis-univ.hu](kadar.kristof@dent.semmelweis-univ.hu) (K.K.); [zelles.tibor@dent.semmelweis-univ.hu](zelles.tibor@dent.semmelweis-univ.hu) (T.Z.)  \n2 Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary  \n3 Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, H-1083, Budapest, Hungary  \n* Correspondence: [zsembery.akos@semmelweis.hu](zsembery.akos@semmelweis.hu)  \nAbstract: This review summarizes the current understanding of the role of transient receptor potential melastatin-subfamily member 7 (TRPM7) channels in the pathophysiology of neoplastic diseases. The TRPM family represents the largest and most diverse group in the TRP superfamily. Its subtypes are expressed in virtually all human organs playing a central role in (patho)physiological events. The TRPM7 protein (along with TRPM2 and TRPM6) is unique in that it has kinase activity in addition to the channel function. Numerous studies demonstrate the role of TRPM7 chanzyme in tumorigenesis and in other tumor hallmarks such as proliferation, migration, invasion and metastasis. Here we provide an up-to-date overview about the possible role of TRMP7 in a broad range of malignancies such as tumors of the nervous system, head and neck cancers, malignant neoplasms of the upper gastrointestinal tract, colorectal carcinoma, lung cancer, neoplasms of the urinary system, breast cancer, malignant tumors of the female reproductive organs, prostate cancer and other neoplastic pathologies. Experimental data show that the increased expression and/or function of TRPM7 are observed in most malignant tumor types. Thus, TRPM7 chanzyme may be a promising target in tumor therapy.  \nKeywords: TRPM7 channel; chanzyme; tumor hallmarks; cancer; malignancy; neoplasm  \n1. TRP Channels  \nThe transient receptor potential (TRP) superfamily consists of non-selective cationpermeable channels, of which 28 polymodal ion channels have already been identified in mammals [1–4] . The TRP superfamily can be divided into seven subgroups based on sequence homology and membrane topology: the TRP-canonical (TRPC), TRP-vanilloid (TRPV), TRP-melastatin (TRPM), TRP-polycystin (TRPP) TRP-Mukolipin (TRPML), TRPAnkyrin (TRPA) and TRP-NOMPC (TRPN; “N” stands for no mechanoreceptor potential C) ion channel subfamilies [4–6] . In general, TRP proteins function as ion channels in the plasma membrane, play a key role in cellular ion homeostasis, and often have a sensory function as well. TRP channels are expressed in all human organs and appear to play a central role in the pathophysiological processes of many diseases including carcinogenesis. An increasing amount of evidence indicates the connection between the various hallmarks of cancer and the altered expression/activity of multiple TRP channels [4,7–16] . TRP channels are","cbCaigT6TH73cBPy","https://ap.wps.com/l/cbCaigT6TH73cBPy","pdf",1444076,31,"English","# Abstract\n# Keywords\n# TRP Channels","[{\"question\":\"What role does TRPM7 play in cancer-related processes?\",\"answer\":\"TRPM7 chanzyme activity is linked to tumorigenesis and several hallmarks of cancer, including proliferation, migration, invasion, and metastasis. Increased expression and/or function of TRPM7 is reported across most malignant tumor types.\"},{\"question\":\"How is TRPM7 different from other TRP family members?\",\"answer\":\"TRPM7 is unique in having kinase activity in addition to its channel function. The review also notes TRPM2 and TRPM6 as related proteins with similar combined characteristics.\"},{\"question\":\"Which types of cancers are discussed regarding TRPM7 involvement?\",\"answer\":\"The review provides an overview across many malignancies, including nervous system tumors, head and neck cancers, upper gastrointestinal neoplasms, colorectal carcinoma, lung cancer, urinary system cancers, breast cancer, female reproductive organ tumors, prostate cancer, and other neoplastic pathologies.\"}]","The Role of TRPM7 in Oncogenesis - review | PDF",1789975348,78]