[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332121-105":3,"doc-detail-332121-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-role-of-the-fibroblast-in-barretts-esophagus-and-esophageal-adenocarcinoma-review","The role of the fibroblast in Barrett’s esophagus and esophageal adenocarcinoma - Review","","Barrett’s esophagus (BE) is a leading risk factor for esophageal adenocarcinoma (EAC), a deadly cancer with limited options and rising US incidence. The review synthesizes current studies on how mesenchyme and cancer-associated fibroblasts (CAFs) contribute to BE and EAC, emphasizing translational potential for cell-targeted therapies. Single-cell RNA sequencing and organoid fibroblast co-culture reveal mesenchymal heterogeneity, CAF-like stromal programs, and fibroblast-driven effects on epithelial plasticity, BE development, cancer progression, and possible treatment resistance.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-role-of-the-fibroblast-in-barretts-esophagus-and-esophageal-adenocarcinoma-review/332121/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-role-of-the-fibroblast-in-barretts-esophagus-and-esophageal-adenocarcinoma-review/332121.png","ImageObject",300,407,{"name":42,"@type":43},"Hazel","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is Barrett’s esophagus important for esophageal adenocarcinoma?","Question",{"text":63,"@type":64},"Barrett’s esophagus is described as the number one risk factor for developing esophageal adenocarcinoma. Its progression is linked to changes that involve mesenchyme and fibroblasts.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What do recent studies show about mesenchyme and fibroblasts in BE and EAC?",{"text":68,"@type":64},"Single-cell RNA sequencing and fibroblast organoid co-culture identify heterogeneity in mesenchymal and fibroblast subgroups. These cells share stromal gene expression similarities and can directly influence epithelium to promote BE development and cancer progression.",{"name":70,"@type":61,"acceptedAnswer":71},"How could targeting cancer-associated fibroblasts be used therapeutically?",{"text":72,"@type":64},"The review highlights targeting CAFs in EAC as a promising therapeutic strategy. It also suggests direct fibroblast targeting may help treat EAC and prevent BE development by affecting epithelial plasticity.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332121,1790081002,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984",7,"REVIEW  \nUPRI RNIENTON The role of the fibroblast in Barrett’s esophagus  \nand esophageal adenocarcinoma  \nHuili Zhu and Ramon U. Jin  \nPurpose of review  \nBarrett’s esophagus (BE) is the number one risk factor for developing esophageal adenocarcinoma (EAC), a deadly cancer with limited treatment options that has been increasing in incidence in the US. In this report, we discuss current studies on the role of mesenchyme and cancer-associated fibroblasts (CAFs) in BE and EAC, and we highlight translational prospects of targeting these cells.  \nRecent findings  \nNew insights through studies using single-cell RNA sequencing (sc-RNA seq) have revealed an important emerging role of the mesenchyme in developmental signaling and cancer initiation. BE and EAC share similar stromal gene expression, as functional classifications of nonepithelial cells in BE show a remarkable similarity to EAC CAFs. Several recent sc-RNA seq studies and novel organoid fibroblast co-culture systems have characterized the subgroups of fibroblasts in BE and EAC, and have shown that these cells can directly influence the epithelium to induce BE development and cancer progression. Targeting the CAFs in EAC with may be a promising novel therapeutic strategy.  \nSummary  \nThe fibroblasts in the surrounding mesenchyme may have a direct role in influencing altered epithelial plasticity during BE development and progression to EAC.  \nKeywords  \ncancer-associated fibroblasts, intestinal metaplasia, plasticity  \nINTRODUCTION: FIBROBLASTS IN DEVELOPMENT AND CANCER  \nThe esophagus is a seemingly simple organ whose major purpose is to transport ingested food to the stomach. It is comprised of a stratified squamousepithelium supported by a connective tissue dense mesenchyme. This intimate relationship between the epithelium and the mesenchyme starts early asthe embryonic esophagus forms from the foregut endoderm [1–3] . The splanchnic mesoderm mediates developmental pathways that lead to esophageal epithelial differentiation including bone morphogenetic protein (BMP), fibroblast growth factor (FGF), Hedgehog(HH),NOTCH,retinoic acid(RA),andWnt signaling [1–3] . Importantly, the developing esophagus depends on a carefully integrated signaling network. Signals such as Wnt [4], NOTCH [5], and RA [5] need tobe activated to promote lung and esophageal specification (e.g., respiratory-esophageal separation); other pathways such as BMP signaling need tobe inhibited (by Noggin [6]) to allow development of the esophagus; and finally signals including Notch [7], BMP [8], and Wnt [9] are needed for maturation and maintenance of the developing esophagus. Recent single-cell transcriptomic data from the  \ndeveloping murine embryonic foregut shows a previously underappreciated heterogeneity of mesenchymal subtypes [10&], Table 1 . There are 17 distinct groupings ofthis developing mesoderm that are intimately related to the developing foregut endoderm during organ/tissue specification and responsive to the same signaling pathways. Specifically, there is a unique developing esophageal mesenchymal population that can be differentiated from adjacent developing stomach, lung, and intestine mesenchymal populations [10&] .  \nSection of Hematology/Oncology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA  \nCorrespondence to Ramon U. Jin, MD, PhD, Section of Hematology/ Oncology, Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, Jones Anderson 535E, Mail Stop 233, Houston, TX 77030, USA. E-mail: [Ramon.Jin@bcm.edu](Ramon.Jin@bcm.edu)  \n[Curr Opin Gastroenterol](Curr Opin Gastroenterol 2024)[ 2024](Curr Opin Gastroenterol 2024), [40:319](40:319)–[327](327)  \nDOI:10.1097/MOG.0000000000001032  \nThis is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in ","cbCais30tPWvkQFJ","https://ap.wps.com/l/cbCais30tPWvkQFJ","pdf",528720,9,"English","# Purpose of review\n# Recent findings\n# Summary\n# Introduction: fibroblasts in development and cancer\n## Key points","[{\"question\":\"Why is Barrett’s esophagus important for esophageal adenocarcinoma?\",\"answer\":\"Barrett’s esophagus is described as the number one risk factor for developing esophageal adenocarcinoma. Its progression is linked to changes that involve mesenchyme and fibroblasts.\"},{\"question\":\"What do recent studies show about mesenchyme and fibroblasts in BE and EAC?\",\"answer\":\"Single-cell RNA sequencing and fibroblast organoid co-culture identify heterogeneity in mesenchymal and fibroblast subgroups. These cells share stromal gene expression similarities and can directly influence epithelium to promote BE development and cancer progression.\"},{\"question\":\"How could targeting cancer-associated fibroblasts be used therapeutically?\",\"answer\":\"The review highlights targeting CAFs in EAC as a promising therapeutic strategy. It also suggests direct fibroblast targeting may help treat EAC and prevent BE development by affecting epithelial plasticity.\"}]","The role of the fibroblast in Barrett’s esophagus and esophageal adenocarcinoma - Review | PDF",1789996898,23,{"code":4,"msg":82,"data":100},[101,105,109,113,118,123,126,130,134,137,141],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},6,"Technology",50,"technology",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":124,"slug":125},40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":127,"show_sort_weight":128,"slug":129},"Research & Report",30,"research-report",{"id":92,"doc_module":4,"doc_module_name":25,"category_name":131,"show_sort_weight":132,"slug":133},"Religion & Spirituality",20,"religion-spirituality",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":135,"show_sort_weight":132,"slug":136},"World Cup","world-cup",{"id":138,"doc_module":4,"doc_module_name":25,"category_name":139,"show_sort_weight":138,"slug":140},10,"Lifestyle","lifestyle",{"id":142,"doc_module":4,"doc_module_name":25,"category_name":143,"show_sort_weight":114,"slug":144},19,"General","general"]