[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-455711-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-455711-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","the-role-of-sphingolipids-in-myocardial-recovery-original-research-clinical","The Role of Sphingolipids in Myocardial Recovery - Original Research-Clinical","","Myocardial recovery after left ventricular assist device (LVAD) support enables advanced heart failure patients to retain their native heart. The study quantifies targeted sphingolipids in serum and cardiac tissue from patients with recovery post-LVAD and compares responders with nonresponders. Circulating ceramide levels remain elevated in nonresponders, while responders show reduced sphingosine-1-phosphate (S1P). Cardiac tissue in nonresponders shows increased S1P. The findings indicate diminished ceramide and S1P as contributors to recovery likelihood and suggest the sphingolipid metabolic pathway as a therapeutic target.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-role-of-sphingolipids-in-myocardial-recovery-original-research-clinical/455711/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-role-of-sphingolipids-in-myocardial-recovery-original-research-clinical/455711.png","ImageObject",300,407,{"name":42,"@type":43},"Genevieve","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-04","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What is studied regarding myocardial recovery after LVAD support?","Question",{"text":62,"@type":63},"The study examines how sphingolipid profiles in blood and cardiac tissue relate to myocardial recovery following LVAD support in advanced heart failure patients.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How do sphingolipid markers differ between responders and nonresponders?",{"text":67,"@type":63},"Responders show reduced circulating S1P levels, while nonresponders have sustained elevated circulating ceramides. In cardiac tissue, nonresponders display increased S1P levels.",{"name":69,"@type":60,"acceptedAnswer":70},"Why might ceramide and S1P be important for recovery?",{"text":71,"@type":63},"The study suggests diminished ceramide and S1P may increase the likelihood of myocardial recovery after LVAD support, implicating sphingolipid metabolic pathways in the process.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},455711,1791072949,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":26,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":127,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","J A C C : B A S I C T O T R A N S L A T I O N A L S C I E N C E V O L . 1 1 , N O . 1 , 2 0 2 6  \n© 2 0 2 6 T H E A U T H O R S . P U B L I S H E D BY E L S E V I E R O N B E H A L F O F T H E A M E R I C A NC O L L E G E O F C A R D I O L O GY F O U N D A T I O N . T H I S I S A N O P E N A C C E S S A R T I C L E U N D E RT H E C C B Y L I C E N S E ( [h t t p : / / c r e a t i v e c o m m o n s . o r g / l i c e n s e s / b y / 4 . 0 /](h t t p : / / c r e a t i v e c o m m o n s . o r g / l i c e n s e s / b y / 4 . 0 /) ) .  \nORIGINAL RESEARCH-CLINICAL  \nThe Role of Sphingolipids in Myocardial Recovery Mediated by Mechanical Unloading and Circulatory Support  \nRana Hamouche, MD,a,b Sean M. Tatum, PHD,c Elizabeth Dranow, PHD,a J. Alan Maschek, PHD,c  \nChristos P. Kyriakopoulos, MD,a Thirupura S. Shankar, PHD,a,b Joseph R. Visker, PHD,a,b Jing Ling, AS,a,b Konstantinos Sideris, MD,a Craig H. Selzman, MD,a,b Abdallah G. Kfoury, MD,a Josef Stehlik, MD, MPH,a  \nRami Alharethi, MD,a James C. Fang, MD,a TingTing Hong, MD, PHD,b,d Sutip Navankasattusas, PHD,a,b Matthew T. Rondina, MD,e,f,g William L. Holland, PHD,c Scott A. Summers, PHD,c Stavros G. Drakos, MD, PHD,a,b Eleni Tseliou, MD, PHDa,b  \nHIGHLIGHTS  \n• The circulating and cardiac sphingolipid profiles in patients showing myocardial recovery following LVAD support are described.  \n• Circulating dhCer(16:0) associated with functional and structural changes in advanced HF following LVAD support.  \n• We identify circulating and cardiac Cerand S1P as potential therapeutic targets for myocardial recovery.  \nISSN 2452-302X [https://doi.org/10.1016/j.jacbts.2025.101435](https://doi.org/10.1016/j.jacbts.2025.101435)  \n2  \nHamouche et al J A C C : B A S I C T O T R A N S L A T I O N A L S C I E N C E V O L . 1 1 , N O . 1 , 2 0 2 6  \nSphingolipids in Myocardial Recovery J A N U A R Y 2 0 2 6 : 1 0 1 4 3 5  \nA B B R E V I A T I O N SA N D A C R O NY M S  \nCer = ceramides  \ndhCer = dihydroceramide dhSM = dihydrosphingomyelin dMRM = dynamic multiple reaction monitoring  \nFA = fatty acid  \nGlcCer = glucosylceramide HF = heart failure  \nLC = liquid chromatography LVAD = left ventricular assist device  \nLVEDD = left ventricular end-diastolic diameter  \nLVEF = left ventricular ejection fraction  \nMS = mass spectrometry PC = phosphatidylcholine QC = quality control  \nS1P = sphingosine-1-phosphate  \nSa1P = sphinganine-1-  \nphosphate  \nSL = sphingolipid SM = sphingomyelin  \nSUMMARY  \nMyocardial recovery after left ventricular assist device (LVAD) support is a critical phenomenon that allows advanced heart failure patients to retain their native heart. We quantified targeted sphingolipids in serum and cardiac tissue of patients who exhibited recovery post-LVAD. Our analysis revealed sustained elevated circulating ceramides levels in nonresponders post-LVAD, whereas responders showed reduced sphingosine-1-phosphate (S1P) levels. In contrast, cardiac tissue from nonresponders displayed increased S1P levels. We suggest that diminished ceramide and S1P may contribute to an increased likelihood of recovery after LVAD support. Collectively, our findings implicate the sphingolipid metabolic pathway as a potential therapeutic target to promote myocardial recovery after mechanical support. (JACC Basic Transl Sci. 2026;11:101435)© 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY license ([http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/)).  \nH  \neart failure (HF) remains the leading cause of death worldwide.1 Whereas heart transplantation is  \nan established treatment for advanced HF, the limited availability of donor hearts has led to the use of left ventricular assist devices (LVADs) as an alternative bridge to transplant.2 Based on previous studies, 10%-30% of patients with advanced HF who undergo LVAD support improve significantly their cardiac function and stru","cbCaihUhNTOjROM2","https://ap.wps.com/l/cbCaihUhNTOjROM2","pdf",6394821,"English","# Highlights\n# Abbreviations and Acronyms\n## Key sphingolipid and clinical biomarkers\n# Summary\n# Background and Rationale\n## Heart failure burden and LVAD as bridge therapy\n## Metabolic inflexibility and energetic remodeling in heart failure\n## Mechanical unloading and circulatory support mechanisms\n## Role of sphingolipids in cellular function and disease","[{\"question\":\"What is studied regarding myocardial recovery after LVAD support?\",\"answer\":\"The study examines how sphingolipid profiles in blood and cardiac tissue relate to myocardial recovery following LVAD support in advanced heart failure patients.\"},{\"question\":\"How do sphingolipid markers differ between responders and nonresponders?\",\"answer\":\"Responders show reduced circulating S1P levels, while nonresponders have sustained elevated circulating ceramides. In cardiac tissue, nonresponders display increased S1P levels.\"},{\"question\":\"Why might ceramide and S1P be important for recovery?\",\"answer\":\"The study suggests diminished ceramide and S1P may increase the likelihood of myocardial recovery after LVAD support, implicating sphingolipid metabolic pathways in the process.\"}]","The Role of Sphingolipids in Myocardial Recovery - Original Research-Clinical | PDF",1790743943,48]