[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-378431-105":59,"doc-detail-378431-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","the-role-of-peroxidasin-in-solid-cancer-progression","The role of peroxidasin in solid cancer progression","","Peroxidasin (PXDN) is a heme-containing peroxidase that catalyzes sulfilimine crosslinking of collagen IV in basement membranes, using hydrogen peroxide and bromide to generate HOBr. During solid tumour progression, basement membrane proteins such as PXDN and collagen IV disperse through the tumour microenvironment, where they interact with cancer cells and change cellular behaviour. This review synthesizes evidence on PXDN functions in normal tissues, its regulation, and reported associations between PXDN expression and patient outcomes, including links to metastasis.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-peroxidasin-in-solid-cancer-progression/378431/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-peroxidasin-in-solid-cancer-progression/378431.png","ImageObject",300,407,{"name":92,"@type":93},"Franzy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is peroxidasin’s primary biological role in basement membranes?","Question",{"text":113,"@type":114},"Peroxidasin catalyzes HOBr-dependent sulfilimine crosslink formation in collagen IV networks, stabilizing basement membrane structure.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why is PXDN relevant during solid tumour progression?",{"text":118,"@type":114},"As the basement membrane is degraded, PXDN and collagen IV can spread through the tumour microenvironment and interact with cancer cells, altering cell behaviour.",{"name":120,"@type":111,"acceptedAnswer":121},"How does PXDN’s HOBr production differ from other heme peroxidases?",{"text":122,"@type":114},"MPO and LPO generate HOCl and HOSCN respectively, while PXDN primarily generates HOBr, which is described as efficient for forming the collagen IV sulfilimine cross-links needed for network stabilization.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},378431,1790464955,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},2336478945519,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Biochemical Society Transactions (2023) 51 1881–1895 [https://doi.org/10.1042/BST20230018](https://doi.org/10.1042/BST20230018)  \nReview Article  \nThe role of peroxidasin in solid cancer progression  \nKaitlin Wyllie1,2, Vasilios Panagopoulos3,4 and Thomas R. Cox1,2  \n1Matrix & Metastasis Lab, The Garvan Institute of Medical Research & the Kinghorn Cancer Centre, Cancer Ecosystems Program, Sydney, NSW 2010, Australia; 2School of Clinical Medicine, St Vincent’s Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia; 3Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, University of Adelaide, Adelaide, Australia; 4Precision Cancer Medicine Theme, Solid Tumour Program, South Australian Health and Medical Research Institute, Adelaide, Australia  \nCorrespondence: Vasilios Panagopoulos ([bill.panagopoulos@adelaide.edu.au](bill.panagopoulos@adelaide.edu.au)) or Thomas R. Cox ([t.cox@garvan.org.au](t.cox@garvan.org.au)  \nReceived: 24 May 2023  \nRevised: 24 September 2023  \nAccepted: 26 September 2023  \nVersion of Record published:  \n6 October 2023  \nPeroxidasin is a heme-containing peroxidase enzyme that plays a vital role in the crosslinking of collagen IV molecules in basement membranes. Collagen IV cross-links are essential for providing structure and mechanical stability throughout tissue development, homeostasis, and wound healing. During cancer progression, the basement membrane is degraded, and proteins typically found in the basement membrane, including peroxidasin and collagen IV, can be found spread throughout the tumour microenvironment where they interact with cancer cells and alter cell behaviour. Whilst peroxidasin is reported tobe up-regulated in a number of different cancers, the role that it plays in disease progression and metastasis has only recently begun to be studied. This review highlights the current literature exploring the known roles of peroxidasin in normal tissues and cancer progression, regulators of peroxidasin expression, and the reported relationships between peroxidasin expression and patient outcome in cancer.  \nIntroduction  \nThe basement membrane is a thin layer of highly specialised extracellular matrix that underlies epithelial and endothelial cells. It plays many important roles including providing structural support, determining the polarity of anchored cells, regulating cell growth and differentiation, and acting as a filter to regulate the movement of molecules between the bloodstream and the tissue [1,2] . During injury and tissue repair, the basement membrane also facilitates aligning cells for migration andre-epithelialization [1] . Collagen IV is the most abundant component present and plays an important role in providing structure to the basement membrane. To stabilise the collagen IV network, collagen IV trimers are cross-linked via their NC1 domains through sulfilimine bond formation between the sulfur group of Met93 and the amine nitrogen on hydroxy-Lys211 (Figure 1A) [3] . This cross-linking is mediated by the potent oxidant hypobromous acid (HOBr), generated by the peroxidase enzyme, peroxidasin (PXDN), and relies on the presence of both hydrogen peroxide and bromide [4,5] . This PXDN-catalysed sulfilimine bond formation is an evolutionarily conserved structural feature of collagen IV networks that is known to be essential for tissue development and function [6] .  \nPXDN is a heme-containing enzyme first identified in the cardiovascular system [7] . Other members of the mammalian heme peroxidase family include myeloperoxidase (MPO), eosinophil peroxidase (EPX or EPO) and lactoperoxidase (LPO) . Peroxidases utilise hydrogen peroxide to form highly reactive intermediates, which then oxidise halide ions (such as bromide, chloride, and thiocyanate) to form hypohalous acids. Both MPO and EPO are key elements of the innate immune response, while LPO is found in exocrine secretions. The hypohalous acids generated by","cbCaisZOtXharsQ0","https://ap.wps.com/l/cbCaisZOtXharsQ0","pdf",2676165,15,"English","# Introduction\n## Basement membrane functions and collagen IV network\n## PXDN as a heme peroxidase and catalytic specificity\n## Comparison with other heme peroxidases in generating HOX acids\n## PXDN regulation and roles in cancer progression","[{\"question\":\"What is peroxidasin’s primary biological role in basement membranes?\",\"answer\":\"Peroxidasin catalyzes HOBr-dependent sulfilimine crosslink formation in collagen IV networks, stabilizing basement membrane structure.\"},{\"question\":\"Why is PXDN relevant during solid tumour progression?\",\"answer\":\"As the basement membrane is degraded, PXDN and collagen IV can spread through the tumour microenvironment and interact with cancer cells, altering cell behaviour.\"},{\"question\":\"How does PXDN’s HOBr production differ from other heme peroxidases?\",\"answer\":\"MPO and LPO generate HOCl and HOSCN respectively, while PXDN primarily generates HOBr, which is described as efficient for forming the collagen IV sulfilimine cross-links needed for network stabilization.\"}]","The role of peroxidasin in solid cancer progression | PDF",1790230075,38]