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It is triggered by diverse signals and contributes to metabolic disorders as well as inflammatory and autoimmune diseases. As a pattern recognition receptor (PRR) expressed across immune cells, NLRP3 functions primarily in myeloid cells. Its role in myeloproliferative neoplasms (MPNs) is central, and targeting IL-1β or NLRP3 may provide a cancer-related therapeutic strategy to complement existing protocols.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-nlrp3-a-star-of-excellence-in-myeloproliferative-neoplasms-review/376585/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-nlrp3-a-star-of-excellence-in-myeloproliferative-neoplasms-review/376585.png","ImageObject",300,407,{"name":92,"@type":93},"Jiven","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":46},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is NLRP3 and why is it important in disease?","Question",{"text":112,"@type":113},"NLRP3 is an inflammasome component activated by different signals. Its overactivation contributes to inflammatory, autoimmune, metabolic disorders, and is linked to carcinoma development.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do myeloproliferative neoplasms (MPNs) develop at the cellular level?",{"text":117,"@type":113},"MPNs are uncommon neoplastic blood disorders affecting the bone marrow, driven by mutations in hematopoietic stem and progenitor cells. These mutations can cause uncontrolled proliferation and/or blocked differentiation.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic direction does the article suggest regarding IL-1β or NLRP3?",{"text":121,"@type":113},"Inhibiting IL-1β or NLRP3 is proposed as a helpful cancer-related therapeutic strategy. 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The Role of NLRP3, a Star of Excellence in Myeloproliferative Neoplasms. Int. J. Mol. Sci. 2023, 24, 4860. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms24054860  \nAcademic Editor: Ana Cristina Gonçalves  \nReceived: 5 February 2023  \nRevised: 23 February 2023  \nAccepted: 27 February 2023  \nPublished: 2 March 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Hematology Section, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari `Aldo Moro', 70124 Bari, Italy  \n2 School of Medicine, University of Bari `Aldo Moro', 70124 Bari, Italy  \n* Correspondence: [francesco.albano@uniba.it](francesco.albano@uniba.it)  \nAbstract: Nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) is the most widely investigated inflammasome member whose overactivation can be a driver of several carcinomas. It is activated in response to different signals and plays an important role in metabolic disordersand inflammatory and autoimmune diseases. NLRP3 belongs to the pattern recognition receptors (PRRs) family, expressed in numerous immune cells, and it plays its primary function in myeloid cells. NLRP3 has a crucial role in myeloproliferative neoplasms (MPNs), considered to be the diseases best studied in the inflammasome context. The investigation of the NLRP3 inflammasome complex is anew horizon to explore, and inhibiting IL-1􀀌 or NLRP3 could be a helpful cancer-related therapeutic strategy to improve the existing protocols.  \nKeywords: myeloproliferative neoplasms; nucleotide-binding domain (NOD)-like receptor protein 3; inflammasome  \n1. Introduction  \nMyeloproliferative neoplasms (MPNs) are a set of uncommon, neoplastic blood disorders that affect the bone marrow. They are characterized by a set of mutations in the hematopoietic stem cells and progenitor cells (HSPCs), from which erythrocytes, leucocytesand platelets are derived. They are genetically extremely varied and exhibit an aberrant HSPC unregulated proliferation and/or an inhibition of the differentiation in the bone marrow (BM) [1–3] . Inflammatory conditions in the BM can lead to DNA mutations and genomic instability, which contribute to or cause the initial impact on the hematopoietic stem cells and trigger the clonal evolution-related mutations in the MPN [4] . The cancerous cell can change the niche to its advantage and at the expense of healthy HSPCs [5] . Asa result, the blood cells proliferate out of control [6] . Polycythemia vera (PV), essential thrombocytemia (ET), primary myelofibrosis (PMF) and chronic myeloid leukemia (CML) are examples of MPNs. They are identified by a rise in erythrocytes, platelets, and bone marrow fibrosis, respectively [7] . CML, associated with the Philadelphia chromosome and sometimes even genomic deletions [8,9], is characterized by a clonal myeloproliferation, leading to a marked overproduction of both mature and immature granulocytes [10] . Some individuals develop PMF during the progression of PV and ET, which is frequently accompanied by complications such as thrombosis or hemorrhages. The worst poss","cbCaitgceto3car9","https://ap.wps.com/l/cbCaitgceto3car9","pdf",981962,14,"English","# Introduction\n# NLRP3 inflammasome in MPNs\n## Disease overview and mutations in MPNs\n## JAK2/CALR/MPL signaling and driver mutations\n## Genetic complexity and inflammasome activation","[{\"question\":\"What is NLRP3 and why is it important in disease?\",\"answer\":\"NLRP3 is an inflammasome component activated by different signals. Its overactivation contributes to inflammatory, autoimmune, metabolic disorders, and is linked to carcinoma development.\"},{\"question\":\"How do myeloproliferative neoplasms (MPNs) develop at the cellular level?\",\"answer\":\"MPNs are uncommon neoplastic blood disorders affecting the bone marrow, driven by mutations in hematopoietic stem and progenitor cells. These mutations can cause uncontrolled proliferation and/or blocked differentiation.\"},{\"question\":\"What therapeutic direction does the article suggest regarding IL-1β or NLRP3?\",\"answer\":\"Inhibiting IL-1β or NLRP3 is proposed as a helpful cancer-related therapeutic strategy. The article frames the NLRP3 inflammasome as a new horizon to explore for improved protocols.\"}]","The Role of NLRP3, a Star of Excellence in Myeloproliferative Neoplasms - Review | PDF",1790220088,35]