[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331422-105":59,"doc-detail-331422-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-role-of-national-population-based-registries-in-pancreatic-cancer-surgery-research-critical-review","The role of national population-based registries in pancreatic cancer surgery research - Critical review","","Research and innovation drive progress in multidisciplinary pancreatic cancer management. Registry-based studies complement randomized clinical trials by offering cost-effectiveness, larger sample sizes, and broader representation of real-world practice. National population-based registries aim to cover the entire national population and, compared with non-NPBR sources, reduce selection bias. Over the past decade, their use in pancreatic cancer surgery research has increased sharply, adding key evidence. Methodological limits may threaten study quality, including uncontrolled data collection and insufficient reporting on registry validation, coverage completeness, and data accuracy, plus risks of double publication and inclusion of irrelevant historical data.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-national-population-based-registries-in-pancreatic-cancer-surgery-research-critical-review/331422/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-national-population-based-registries-in-pancreatic-cancer-surgery-research-critical-review/331422.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are registry-based studies important for pancreatic cancer management research?","Question",{"text":112,"@type":113},"They complement randomized clinical trials by being cost-effective, enabling larger samples, and reflecting real-world clinical practice. They help address research questions that other study formats may not handle optimally.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What advantages do national population-based registries (NPBRs) offer compared with non-NPBRs?",{"text":117,"@type":113},"NPBRs aim to cover entire national populations, allowing incidence and prevalence calculations. They are also described as less prone to selection bias than studies using data from non-NPBR registries.",{"name":119,"@type":110,"acceptedAnswer":120},"What methodological shortcomings can compromise registry-based study quality?",{"text":121,"@type":113},"Limitations include lack of control over data collection and insufficient reporting about the source registry or database’s validation, coverage, and data completeness and accuracy. The text also flags risks of double publication and the use of historical data that may not match current research questions.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331422,1790381194,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","’Invited Special Paper   \nThe role of national population-based registries in pancreatic cancer surgery research  \nEduard Jonas, MB, ChB, MMed, PhD, Christo Kloppers, MB, ChB, MMed, MPhil  \nAbstract  \nResearch and innovation are critical for advancing the multidisciplinary management of pancreatic cancer. Registry-based studies (RBSs) are a complement to randomized clinical trials (RCTs) . Compared with RCTs, RBSs offer cost-effectiveness, larger sample sizes, and representation of real-world clinical practice. National population-based registries (NPBRs) aim to cover the entire national population, and studies based on NPBRs are, compared to non-NPBRs, less prone to selection bias. The last decade has witnessed a dramatic increase in NPBRs in pancreatic cancer surgery, which has undoubtedly added invaluable knowledge to the body of evidence on pancreatic cancer management. However, several methodological shortcomings may compromise the quality of registry-based studies. These include a lack of control over data collection and a lack of reporting on the quality of the source registry or database in terms of validation of coverage and data completeness and accuracy. Furthermore, there is a significant risk of double publication from the most commonly used registries as well as the inclusion of historical data that is not relevant or representative of research questions addressing current practices.  \nKeywords: database, national, pancreatic cancer, population-based, registry, surgery  \nIntroduction  \nPancreatic surgery is a central component of the multidisciplinary management of pancreatic malignancies. Pancreatic surgery maybe challenging due to complicated anatomy, proximity to vital structures, and advanced disease stage, and is associated with potential serious postoperative complications, resulting in mortality and morbidity [1] . Research that creates high-level evidence through well-designed clinical studies and trials is invaluable for advancing the multidisciplinary management of pancreatic malignancies. Randomized clinical trials (RCTs) are still regarded as the most powerful clinical research tool, generating the highest levels of evidence that often result in  \nDepartment of Surgery, University of Cape Town Faculty of Health Sciences, Surgical  \nGastroenterology Unit, Groote Schuur Hospital, Cape Town, South Africa Sponsorships or competing interests that maybe relevant to content are disclosed atthe end of this article.  \n*Corresponding author. Address: E23 Room 37, New Main Building, University of Cape Town and Groote Schuur Hospital, Observatory, 7925, Cape Town, South Africa. Tel.: + 27 21 404 3156; Tel.: + 27 720 611 659;  \nE-mail: [eduard.jonas@uct.ac.za](eduard.jonas@uct.ac.za) (E. Jonas).  \nCopyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms.  \nInternational Journal of Surgery (2024) 110:6155–6162  \nReceived 6 July 2023; Accepted 11 March 2024  \nSupplemental Digital Content is available for this article. Direct URL citations are provided in the HTML and PDF versions of this article on the journal's website, [www.lww.com/international-journal-of-surgery](www.lww.com/international-journal-of-surgery).  \nPublished online 4 April 2024  \n[http://dx.doi.org/10.1097/JS9.0000000000001405](http://dx.doi.org/10.1097/JS9.0000000000001405)  \nHIGHLIGHTS  \n• Registry-based studies are a complement to randomized controlled clinical trials.  \n• Studies based on national population-based registries have several advantages, for example, being less prone to selection bias.  \n• A steep increase was seen in pancreatic cancer surgery studies based on national population-based registries over the last decade.  \n• A minorit","cbCainjeHCtDcIFg","https://ap.wps.com/l/cbCainjeHCtDcIFg","pdf",349516,"English","# Abstract\n# Introduction\n## Healthcare registries and registry-based research\n## Healthcare registries\n# Highlights","[{\"question\":\"Why are registry-based studies important for pancreatic cancer management research?\",\"answer\":\"They complement randomized clinical trials by being cost-effective, enabling larger samples, and reflecting real-world clinical practice. They help address research questions that other study formats may not handle optimally.\"},{\"question\":\"What advantages do national population-based registries (NPBRs) offer compared with non-NPBRs?\",\"answer\":\"NPBRs aim to cover entire national populations, allowing incidence and prevalence calculations. They are also described as less prone to selection bias than studies using data from non-NPBR registries.\"},{\"question\":\"What methodological shortcomings can compromise registry-based study quality?\",\"answer\":\"Limitations include lack of control over data collection and insufficient reporting about the source registry or database’s validation, coverage, and data completeness and accuracy. The text also flags risks of double publication and the use of historical data that may not match current research questions.\"}]","The role of national population-based registries in pancreatic cancer surgery research - Critical review | PDF",1789993216]