[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331946-105":59,"doc-detail-331946-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","the-role-of-muc1-in-renal-cell-carcinoma","The Role of MUC1 in Renal Cell Carcinoma","","Mucins are high-molecular-weight glycoproteins, and MUC1 is widely studied in diverse cancers. In many human epithelial malignancies, MUC1 is frequently overexpressed, and intracellular activities influence cell biology. Overexpression can enhance cancer cell proliferation by modulating metabolism, and loss of epithelial polarity disperses mucins across the membrane, disrupting the mucin interactome. Tumor-associated MUC1 often shows lost apical localization and aberrant glycosylation that may generate tumor-related antigen epitopes. Renal cell carcinoma is the most common kidney cancer, yet the precise role of MUC1 remains unclear, with evidence suggesting involvement in oncogenic pathways including proliferation, metabolic reprogramming, chemoresistance, and angiogenesis. This review explores MUC1 function and the meaning of its overexpression in epithelial tumors, focusing on RCC.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-muc1-in-renal-cell-carcinoma/331946/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-muc1-in-renal-cell-carcinoma/331946.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",16,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is MUC1 and why is it important in cancer biology?","Question",{"text":113,"@type":114},"MUC1 is a transmembrane mucin protein widely studied across cancers. It is frequently overexpressed in epithelial malignancies and participates in signaling pathways related to growth, proliferation, metabolism, and apoptosis.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does MUC1 overexpression contribute to tumor progression?",{"text":118,"@type":114},"MUC1 overexpression can enhance cancer cell proliferation by modulating cell metabolism. It also relates to disrupted epithelial polarity, producing abnormal mucin interactions with the membrane.",{"name":120,"@type":111,"acceptedAnswer":121},"What is the proposed role of MUC1 in renal cell carcinoma (RCC)?",{"text":122,"@type":114},"The exact role of MUC1 in RCC is unknown, but evidence suggests involvement in oncogenic pathways such as proliferation, metabolic reprogramming, chemoresistance, and angiogenesis.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},331946,1790076141,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","biomolecules  \nReview  \nThe Role of MUC1 in Renal Cell Carcinoma  \nMartina Milella 1, Monica Rutigliano 1, Francesco Lasorsa 1, Matteo Ferro 2, Roberto Bianchi 2, Giuseppe Fallara 2, Felice Crocetto 3, Savio Domenico Pandolfo 3,4, Biagio Barone 5, Antonio d’Amati 6, Marco Spilotros 1, Michele Battaglia 1, Pasquale Ditonno 1 and Giuseppe Lucarelli 1, *  \nCitation: Milella, M.; Rutigliano, M.; Lasorsa, F.; Ferro, M.; Bianchi, R.; Fallara, G.; Crocetto, F.; Pandolfo, S.D.; Barone, B.; d’Amati, A.; et al. The Role of MUC1 in Renal Cell Carcinoma. Biomolecules 2024, 14, 315. [https://](https://)[ ](https://)[doi.org/10.3390/biom14030315](doi.org/10.3390/biom14030315)  \nAcademic Editor: Lu-Gang Yu  \nReceived: 21 January 2024  \nRevised: 4 March 2024  \nAccepted: 6 March 2024  \nPublished: 7 March 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Urology, Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70124 Bari, Italy; pasquale.ditonno@uniba.it (P.D.)  \n2 Division of Urology, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 71013 Milan, Italy  \n3 Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy  \n4 Department of Urology, University of L’Aquila, 67010 L’Aquila, Italy  \n5 Division of Urology, Department of Surgical Sciences, AORN Sant’Anna e San Sebastiano, 81100 Caserta, Italy  \n6 Pathology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari“Aldo Moro”, 70124 Bari, Italy  \n* Correspondence: [giuseppe.lucarelli@uniba.it](giuseppe.lucarelli@uniba.it)  \nAbstract: Mucins are a family of high-molecular-weight glycoproteins. MUC1 is widely studied for its role in distinct types of cancers. In many human epithelial malignancies, MUC1 is frequently overexpressed, and its intracellular activities are crucial for cell biology. MUC1 overexpression can enhance cancer cell proliferation by modulating cell metabolism. When epithelial cells lose their tight connections, due to the loss of polarity, the mucins become dispersed on both sides of the epithelial membrane, leading to an abnormal mucin interactome with the membrane. Tumor-related MUC1 exhibits certain features, such as loss of apical localization and aberrant glycosylation that might cause the formation of tumor-related antigen epitopes. Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies and it is the most common kidney cancer. The exact role of MUC1 in this tumor is unknown. Evidence suggests that it may play a role in several oncogenic pathways, including proliferation, metabolic reprogramming, chemoresistance, and angiogenesis. The purpose of this review is to explore the role of MUC1 and the meaning of its overexpression in epithelial tumors and in particular in RCC.  \nKeywords: mucin-1; MUC1; cancers; renal cell carcinoma; CA15-3; therapy  \n1. Introduction  \nMucins are a family of high-molecular-weight glycoproteins. Among them, transmembrane protein mucin-1 (MUC1) is widely studied for its role in several kinds of cancers [1] . Usually, epithelial cells’ surfaces are covered in MUC1, which creates a dense mesh that protects cells from harsh external circumstances, forming a protective barrier across the mucosal surface [2] . In many epithelial malignancies, including breast, colon, liver, lung, ovarian, and pancreatic cancer, MUC1 is frequently overexpressed, and its intracellular activities are crucial for cell biology. Indeed, this protein takes part in several signaling pathways involved","cbCaiaXMMZHoDsUf","https://ap.wps.com/l/cbCaiaXMMZHoDsUf","pdf",721508,17,"English","# Introduction\n# MUC1 Structure and Biological Properties","[{\"question\":\"What is MUC1 and why is it important in cancer biology?\",\"answer\":\"MUC1 is a transmembrane mucin protein widely studied across cancers. It is frequently overexpressed in epithelial malignancies and participates in signaling pathways related to growth, proliferation, metabolism, and apoptosis.\"},{\"question\":\"How does MUC1 overexpression contribute to tumor progression?\",\"answer\":\"MUC1 overexpression can enhance cancer cell proliferation by modulating cell metabolism. It also relates to disrupted epithelial polarity, producing abnormal mucin interactions with the membrane.\"},{\"question\":\"What is the proposed role of MUC1 in renal cell carcinoma (RCC)?\",\"answer\":\"The exact role of MUC1 in RCC is unknown, but evidence suggests involvement in oncogenic pathways such as proliferation, metabolic reprogramming, chemoresistance, and angiogenesis.\"}]","The Role of MUC1 in Renal Cell Carcinoma | PDF",1789995924,43]