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MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and are increasingly investigated as biomarker candidates across cancers. Literature evidence indicates that miRNA expression patterns can reflect key processes involved in carcinogenesis. The article synthesizes findings on selected miRNAs and their mechanistic roles in endometrial cancer development, emphasizing their potential use for diagnostic and prognostic applications.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-mirnas-in-the-development-proliferation-and-progression-of-endometrial-cancer-research-focus/381381/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-mirnas-in-the-development-proliferation-and-progression-of-endometrial-cancer-research-focus/381381.png","ImageObject",300,407,{"name":92,"@type":93},"Aria Callaghan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-24",true,{"@type":101,"interactionType":102,"userInteractionCount":8},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"Why are microRNAs considered important in endometrial cancer?","Question",{"text":111,"@type":112},"miRNAs regulate gene expression post-transcriptionally, influencing biological processes linked to carcinogenesis. 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The Role of miRNAs in the Development, Proliferation, and Progression of Endometrial Cancer. Int. J. Mol. Sci. 2023, 24, 11489 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms241411489  \nAcademic Editor: Marcin Majka  \nReceived: 31 May 2023  \nRevised: 30 June 2023  \nAccepted: 13 July 2023  \nPublished: 15 July 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Gynecology, Gynecology Oncology and Obstetrics, Fryderyk Chopin University Hospital,  \nF.Szopena 2, 35-055 Rzeszow, Poland; [annabogaczyk@interia.pl](annabogaczyk@interia.pl) (A.B.); [tomasz.zuzak@gmail.com](tomasz.zuzak@gmail.com) (T.Z.);  \n[jtkluz@interia.pl](jtkluz@interia.pl) (T.K.)  \n2 Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Medical College of Rzeszow University, Warzywna 1a, 35-959 Rzeszow, Poland; [izazawlik@gmail.com](izazawlik@gmail.com)  \n[3](3 Institute of Medical Sciences)[ Institute of Medical Sciences](3 Institute of Medical Sciences), [Medical College of Rzeszow University](Medical College of Rzeszow University), [Kopisto 2a](Kopisto 2a), [35-959 Rzeszow](35-959 Rzeszow), [Poland](Poland)[ ](Poland)[4](4 Department of Pathology)[ Department of Pathology](4 Department of Pathology), [Fryderyk Chopin University Hospital](Fryderyk Chopin University Hospital), [F.Szopena 2](F.Szopena 2), [35-055 Rzeszow](35-055 Rzeszow), [Poland](Poland);  \n[marta.kluz@interia.pl](marta.kluz@interia.pl)  \n* [Correspondence: npotocka@ur.edu.pl](Correspondence: npotocka@ur.edu.pl)  \nAbstract: Endometrial cancer is one of the most common cancers in developing and developed countries. Although the detection of this cancer is high at the early stages, there is still a lack of markers to monitor the disease, its recurrence, and metastasis. MiRNAs are in charge of the post-transcriptional regulation of genes responsible for the most important biological processes, which is why they are increasingly used as biomarkers in many types of cancer. Many studies have demonstrated the influence of miRNAs on the processes related to carcinogenesis. The characteristics of miRNA expression profiles in endometrial cancer will allow their use as diagnostic and prognostic biomarkers. This paper focuses on the discussion of selected miRNAs based on the literature and their role in the development of endometrial cancer.  \nKeywords: miRNA; endometrial cancer; epigenetics; carcinogenesis  \n1. Introduction  \n1.1. Endometrial Cancer  \nEndometrial cancer (EC) was diagnosed in 417,367 women worldwide in 2020, with the highest burden of the disease recorded in North America and Western Europe. The incidence of EC is rapidly increasing. As of 2020, uterine cancer is the fourth most common female cancer in Europe, with an incidence of 12.9–20.2 per 100,000 women and a mortality rate of 2.0–3.7 per 100,000 women [1] . The high incidence rate in North America and Western Europe can be attributed to the high prevalence of lifestyle risk factors for EC, such as high standard of living, aging population, and obesity, which are associated with approximately 50% of EC cases [2] .  \nIn the historical morphological division (according to Bokhman's dualistic theory), EC was classified as type I, the so-called endometroid, which is associated with excessive estrogen stimulation, develops on the basis of endometrial hy","cbCaigKou09EjwgO","https://ap.wps.com/l/cbCaigKou09EjwgO","pdf",652140,24,"English","# Abstract\n# 1. Introduction\n## 1.1. Endometrial Cancer\n## 1.2. MicroRNAs","[{\"question\":\"Why are microRNAs considered important in endometrial cancer?\",\"answer\":\"miRNAs regulate gene expression post-transcriptionally, influencing biological processes linked to carcinogenesis. Their expression profiles are increasingly studied as biomarker signals for diagnosis and prognosis.\"},{\"question\":\"What problem does the article highlight regarding endometrial cancer management?\",\"answer\":\"Although early detection rates are high, there is still a lack of effective markers to monitor disease progression, recurrence, and metastasis.\"},{\"question\":\"How does the article connect miRNAs to endometrial cancer development and progression?\",\"answer\":\"It reviews selected miRNAs reported in the literature and discusses their roles in processes driving endometrial cancer development, supporting their potential relevance to therapeutic and clinical strategies.\"}]","The Role of miRNAs in the Development, Proliferation, and Progression of Endometrial Cancer - Research Focus | PDF",1790245077]