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This study assessed whether miR-557 regulates cervical cancer malignancy by targeting TAOK1, using 113 paired clinical tissue samples and qRT-PCR for expression, along with functional assays and ferroptosis-related measurements in HeLa and SiHa cells. Results link low miR-557 to worse clinicopathological features and prognosis, and demonstrate tumor-suppressive and ferroptosis-modulating effects via TAOK1.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-mir-557-in-modulating-cervical-cancer-malignancy-by-targeting-taok1/346024/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-mir-557-in-modulating-cervical-cancer-malignancy-by-targeting-taok1/346024.png","ImageObject",300,407,{"name":92,"@type":93},"Clementine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the objective of the study on miR-557?","Question",{"text":113,"@type":114},"To determine whether miR-557 regulates cervical cancer progression by targeting TAOK1.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was miR-557 expression measured in clinical samples?",{"text":118,"@type":114},"miR-557 expression was detected using qRT-PCR in 113 pairs of cervical cancer tissues and adjacent tissues.",{"name":120,"@type":111,"acceptedAnswer":121},"What functional effects did miR-557 overexpression show?",{"text":122,"@type":114},"Overexpressing miR-557 inhibited cervical cancer cell proliferation, migration, and invasion, and it altered ferroptosis-related indicators by increasing Fe2+ while decreasing GSH and GSH-Px activity.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},346024,1791028353,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},1374391974564,"https://ap-avatar.wpscdn.com/avatar/14000253aa45c000a9e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779874745381141002","Yin et al. Hereditas (2026) 163:87 Hereditas  \n[https://doi.org/10.1186/s41065-026-00695-6](https://doi.org/10.1186/s41065-026-00695-6)  \nRESEARCH Open Access  \nThe role of miR-557 in modulating cervical cancer malignancy by targeting TAOK1  \nYilin Yin1†, Yingying Huang2†, Li Lin3, Mingxiu Cui4 and Linge Zhong5*  \nAbstract  \nBackground Cervical cancer (CC) remains a major threat to women’s health globally. Although miR-557 is a tumor suppressor in multiple cancers, its role in CC remains unclear.  \nObjective This study investigated whether miR-557 regulates CC progression by targeting TAOK1 .  \nMethods This study collected 113 pairs of cervical cancer tissues and adjacent tissues. The expression of miR-557 was detected by qRT-PCR, and its relationship with clinicopathological features and prognosis was analyzed. In HeLa and SiHa cell lines, we performed functional assays (CCK-8, Transwell) and measured ferroptosis-related indicators (Fe²⁺, GSH, GSH-Px) after transfecting miR-557 mimic or TAOK1 overexpression vectors. The miR-557/TAOK1 targeting relationship was validated by dual-luciferase reporter assay and rescue experiments.  \nResults miR-557 was significantly downregulated in CC tissues and cell lines. Low miR-557 expression correlated with advanced FIGO stage, LNM, and poor prognosis. Functionally, miR-557 overexpression inhibited CC cell proliferation, migration, and invasion, accompanied by increased Fe²⁺ levels and decreased GSH and GSH-Px activity. TAOK1 was identified as a direct target of miR-557, and its overexpression reversed the tumor-suppressive effects and ferroptosisrelated changes induced by miR-557 .  \nConclusions miR-557 is significantly downregulated in CC and exerts tumor-suppressive functions. By targeting TAOK1, it inhibits the malignant progression of CC cells and may act as a promising biomarker for CC.  \nKeywords miR-557, TAOK1, Cervical cancer, Proliferation, Biomarker  \n†Yilin Yin andYingying Huang have the same contribution to the article.  \n*Correspondence:  \nLinge Zhong  \n[zhonglingedr@163.com](zhonglingedr@163.com)  \n1Shanghai Medical College of Fudan University, Shanghai 200032, China 2People’s Hospital of Yangjiang, Guangdong 529500, China 3Department of Gynecology, The People’s Hospital of Longhua, Shenzhen, Shenzhen 518100, China  \n4Department of gynaecology and obstetrics, Nanjing LuHe People’s Hospital, Nanjing 211500, China  \n5Department of Obstetrics and Gynecology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 222, Huanhu West rd Road, Nanhui NewTown, Pudong New District, Shanghai 201306, China  \nIntroduction  \nCervical cancer (CC) remains a leading malignancy among women worldwide, with persistently high incidence and mortality rates, particularly in developing regions with limited medical resources [1, 2]. Although human papillomavirus screening and preventive vaccination have been implemented in most countries, the prevention and treatment of CC still face severe challenges due to the uneven distribution of medical resources and lagging public awareness [3]. Moreover, current mainstream early diagnostic methods have limitations in sensitivity and specificity, making it difficult to fully meet the demands of precision screening [1]. Therefore, identifying novel biomarkers has become a key priority for  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your in","cbCaiaYyljZPkWZ4","https://ap.wps.com/l/cbCaiaYyljZPkWZ4","pdf",4634857,"English","# Abstract\n## Background\n## Objective\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the objective of the study on miR-557?\",\"answer\":\"To determine whether miR-557 regulates cervical cancer progression by targeting TAOK1.\"},{\"question\":\"How was miR-557 expression measured in clinical samples?\",\"answer\":\"miR-557 expression was detected using qRT-PCR in 113 pairs of cervical cancer tissues and adjacent tissues.\"},{\"question\":\"What functional effects did miR-557 overexpression show?\",\"answer\":\"Overexpressing miR-557 inhibited cervical cancer cell proliferation, migration, and invasion, and it altered ferroptosis-related indicators by increasing Fe2+ while decreasing GSH and GSH-Px activity.\"}]","The role of miR-557 in modulating cervical cancer malignancy by targeting TAOK1 | PDF",1790059720]