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MicroRNAs show promise as blood biomarkers and also as tissue or urine markers.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-role-of-microrna-in-the-prognosis-and-diagnosis-of-ovarian-cancer/375978/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-role-of-microrna-in-the-prognosis-and-diagnosis-of-ovarian-cancer/375978.png","ImageObject",300,407,{"name":42,"@type":43},"Fahsai","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-25","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main purpose of this review?","Question",{"text":63,"@type":64},"To evaluate how microRNAs can contribute to prognosis and diagnosis in ovarian cancer by synthesizing results from published studies.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do the included prognostic studies assess microRNA relevance?",{"text":68,"@type":64},"They report patient survival associated with microRNAs using Kaplan–Meier curves.",{"name":70,"@type":61,"acceptedAnswer":71},"How is diagnostic performance of microRNAs evaluated in the review?",{"text":72,"@type":64},"Diagnostic studies present results using ROC curves, with microRNAs assessed often as blood biomarkers and sometimes as tissue or urine markers.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},375978,1790538860,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":108},549768702563,"https://ap-avatar.wpscdn.com/avatar/8000c4aa63b76e948b?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786536092046926083","Review  \nThe Role of microRNA in the Prognosis and Diagnosis of Ovarian Cancer  \nMateusz Kozłowski *, Dominika Borzyszkowska , Anna Golara , Jerzy Lubikowski and Aneta Cymbaluk-Płoska  \nAcademic Editors: Laura Mariuzzi, Alessandro Mangogna and Maria Orsaria  \nReceived: 26 February 2025  \nRevised: 1 April 2025  \nAccepted: 4 April 2025  \nPublished: 5 April 2025  \nCitation: Kozłowski, M.;  \nBorzyszkowska, D.; Golara, A.; Lubikowski, J.; Cymbaluk-Płoska, A. The Role of microRNA in the Prognosis and Diagnosis of Ovarian Cancer. Int. J. Mol. Sci. 2025, 26, 3413 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms26073413  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \nDepartment of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powsta ´nców Wielkopolskich 72, 70-111 Szczecin, Poland  \n* [Correspondence: mateusz.kozlowski@pum.edu.pl](Correspondence: mateusz.kozlowski@pum.edu.pl)  \nAbstract: Ovarian cancer (OC) is one of the most common cancers in women. Biomarkers for OC are still being sought. The aim of this review was to evaluate microRNAs in the prognosis and diagnosis of OC. We conducted a literature review searching for articles published from January 2014 to September 2024 . We included articles presenting the association of microRNAs with ovarian cancer prognosis, where patient survival was shown by the Kaplan–Meier curve, and articles presenting the association of microRNAs with ovarian cancer diagnosis, where the results were presented as an ROC curve. MicroRNAs are promising clinical markers in ovarian cancer patients. As is shown here, expression (high or low) of various miRNAs was differentially associated with survival in OC patients, with some miRNAs being associated with a longer survival and some with a shorter survival. In the absence of diagnostic markers for OC, the raised role of miRNAs in diagnosis seems all the more important. The diagnostic value of miRNAs has been shown, mostly as blood biomarkers, although they have also been evaluated as tissue or urine markers. MiRNAs have an important role as clinical biomarkers for ovarian cancer, not only as single molecules, but also as biomarker pairs or panels of miRNAs. It should be noted that most of the miRNAs reviewed here have been studied once, so despite the promising results, it seems necessary to conduct studies to confirm or negate the results obtained.  \nKeywords: ovarian cancer; cancer; prognosis; diagnosis; biomarker; marker; survival; microRNA; miRNA  \n1. Introduction  \nOvarian cancer (OC) is the eighth most common and fifth most lethal cancer among women worldwide. Despite being the third most common gynecological cancer after uterine and cervical cancers, this illness is more deadly [1,2] . OC has three main histopathological types (epithelial ovarian cancer, germ cell tumors, and sex cord and stromal tumors), which differ in pathogenesis, biological behavior, histological morphology, clinical presentation, treatment methods, and prognosis. According to statistics, approximately 93% of patients can live longer than 5 years after diagnosis if the disease is detected with a small tumor volume or in a localized stage (stages IA and IB) [3,4] . Therefore, the development of a sensitive and specific biomarker enabling early diagnosis and screening for OC is of great importance. Diagnostics include a physical examination and transvaginal ultrasound (TVUS) . Unfortunately, the screening strategy for the earlier detection of OC still requires further research and standardization. The most commonly used biomarker in clinical practice for detecting ovarian cancer is cancer antigen 125 (CA1","cbCaipWPK1TEcJHN","https://ap.wps.com/l/cbCaipWPK1TEcJHN","pdf",1966485,16,"English","# Introduction\n## Biomarkers and clinical context in ovarian cancer\n## MicroRNAs and their biological basis\n# Review aim and evidence selection\n## Prognostic evidence criteria\n## Diagnostic evidence criteria","[{\"question\":\"What is the main purpose of this review?\",\"answer\":\"To evaluate how microRNAs can contribute to prognosis and diagnosis in ovarian cancer by synthesizing results from published studies.\"},{\"question\":\"How do the included prognostic studies assess microRNA relevance?\",\"answer\":\"They report patient survival associated with microRNAs using Kaplan–Meier curves.\"},{\"question\":\"How is diagnostic performance of microRNAs evaluated in the review?\",\"answer\":\"Diagnostic studies present results using ROC curves, with microRNAs assessed often as blood biomarkers and sometimes as tissue or urine markers.\"}]","The Role of microRNA in the Prognosis and Diagnosis of Ovarian Cancer | PDF",1790216889]