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Evidence indicates that shifts in intestinal microbiome composition and abundance may influence GI cancer development, yet the underlying mechanisms remain incompletely defined. This review synthesizes the significance of intestinal microbiomes in colorectal, gastric, hepatic, and esophageal cancers and examines how microbiomes affect treatment approaches, including chemotherapy, immunotherapy, and radiotherapy, by detailing proposed molecular and immunological pathways.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-microbiomes-in-gastrointestinal-cancers-new-insights/333154/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-microbiomes-in-gastrointestinal-cancers-new-insights/333154.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main focus of this review?","Question",{"text":112,"@type":113},"The review examines the significance of microbiomes in gastrointestinal cancers and how intestinal microbes may affect cancer progression and treatment outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which GI cancer types are discussed?",{"text":117,"@type":113},"It discusses several common GI malignancies, including colorectal, gastric, hepatic (liver) and esophageal cancers, as part of the link between microbiome alterations and disease progression.",{"name":119,"@type":110,"acceptedAnswer":120},"How might gut microbiomes influence cancer therapies?",{"text":121,"@type":113},"The review explores mechanisms through which intestinal microbes can alter the efficacy of chemotherapy, immunotherapy, and radiotherapy, including effects on immune responses and inflammation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333154,1790142820,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","TYPE Review  \nPUBLISHED 01 February 2024 DOI 10.3389/fonc.2023.1344328  \nOPEN ACCESS  \nEDITED BY  \nRalf Weiskirchen,  \nRWTH Aachen University, Germany  \nREVIEWED BY Neha Nanda,  \nHarvard Medical School, United States Ali H Zaidi,  \nAllegheny Health Network, United States  \n*CORRESPONDENCE Hamed Afkhami  \n [hamedafkhami70@gmail.com](hamedafkhami70@gmail.com)  \nRECEIVED 01 December 2023  \nACCEPTED 20 December 2023  \nPUBLISHED 01 February 2024  \nCITATION  \nYarahmadi A and Afkhami H (2024) The role of microbiomes in gastrointestinal cancers: new insights.  \nFront. Oncol. 13:1344328 .  \ndoi: 10.3389/fonc.2023.1344328  \nCOPYRIGHT  \n© 2024 Yarahmadi and Afkhami. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nThe role of microbiomes in gastrointestinal cancers:  \nnew insights  \nAref Yarahmadi 1 and Hamed Afkhami 2,3,4*  \n1 Department of Biology, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran, 2 Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran, 3Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran, 4 Department of Medical Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran  \nGastrointestinal (GI) cancers constitute more than 33% of new cancer cases worldwide and pose a considerable burden on public health. There exists a growing body of evidence that has systematically recorded an upward trajectory in GI malignancies within the last 5 to 10 years, thus presenting a formidable menace to the health of the human population. The perturbations in GI microbiota may have a noteworthy influence on the advancement of GI cancers; however, the precise mechanisms behind this association are still not comprehensively understood. Some bacteria have been observed to support cancer development, while others seem to provide a safeguard against it. Recent studies have indicated that alterations in the composition and abundance of microbiomes could be associated with the progression of various GI cancers, such as colorectal, gastric, hepatic, and esophageal cancers . Within this comprehensive analysis, we examine the significance of microbiomes, particularly those located in the intestines, in GI cancers. Furthermore, we explore the impact of microbiomes on various treatment modalities for GI cancer, including chemotherapy, immunotherapy, and radiotherapy. Additionally, we delve into the intricate mechanisms through which intestinal microbes influence the efficacy of GI cancer treatments.  \nKEYWORDS  \ngastrointestinal cancer, gut microbiome, microbiota, cancer therapy, inflammation  \nFrontiers in Oncology 01 [frontiersin.org](frontiersin.org)  \nYarahmadi and Afkhami 10.3389/fonc.2023.1344328  \nGRAPHICAL ABSTRACT  \nMicrobiomes in Gastrointestinal Cancers.  \nIntroduction  \nGastrointestinal (GI) malignancies constitute approximately one-third of all newly diagnosed cancer cases globally and pose asignificant public health challenge. Colorectal cancer (CRC), Gastric cancer (GC), liver cancer, and esophageal cancer are the most commonly observed GI malignancies across the globe (1, 2) . Since GI malignancies have been on the rise over the past 5 to 10 years, there is a severe health risk to people due to this trend. The past decade has witnessed the substantiation of the role played by genetic and epigenetic factors in the development of cancer. This has been achieved through the extensive genomic and transcriptome sequencing endeavors undertaken by multiple multinational research initiatives (3) . According to current studies, 2.7 million individuals worldwid","cbCaiucntmXC8Bv2","https://ap.wps.com/l/cbCaiucntmXC8Bv2","pdf",5515088,27,"English","# Introduction\n## Microbiomes and GI cancer overview\n## Risk factors and microbiota homeostasis\n## Microbiome roles in carcinogenesis\n## Impact on treatment modalities\n### Chemotherapy, immunotherapy, and radiotherapy","[{\"question\":\"What is the main focus of this review?\",\"answer\":\"The review examines the significance of microbiomes in gastrointestinal cancers and how intestinal microbes may affect cancer progression and treatment outcomes.\"},{\"question\":\"Which GI cancer types are discussed?\",\"answer\":\"It discusses several common GI malignancies, including colorectal, gastric, hepatic (liver) and esophageal cancers, as part of the link between microbiome alterations and disease progression.\"},{\"question\":\"How might gut microbiomes influence cancer therapies?\",\"answer\":\"The review explores mechanisms through which intestinal microbes can alter the efficacy of chemotherapy, immunotherapy, and radiotherapy, including effects on immune responses and inflammation.\"}]","The role of microbiomes in gastrointestinal cancers: new insights | PDF",1790001154,68]