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This review focuses on the mitogen-activated protein kinase (MAPK) pathway as a key driver of gastric cancer development, regulating proliferation, invasion, migration, and metastasis. It summarizes how pathway alterations arise from genetic and epigenetic changes, links MAPK crosstalk to Helicobacter pylori- and Epstein-Barr virus-driven carcinogenesis, and highlights modulation by miRNAs and lncRNAs. It also surveys therapeutic opportunities including herbal medicines, MAPK inhibitors, and immunosuppressants.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-mapk-pathway-in-gastric-cancer-unveiling-molecular-crosstalk-and-therapeutic-prospects/329671/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-mapk-pathway-in-gastric-cancer-unveiling-molecular-crosstalk-and-therapeutic-prospects/329671.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is the MAPK pathway important in gastric cancer?","Question",{"text":112,"@type":113},"The review explains that MAPK signaling transmits extracellular cues to intracellular responses and its cascades are altered by genetic and epigenetic variations, driving key malignant behaviors such as proliferation, invasion, migration, and metastasis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do Helicobacter pylori and Epstein-Barr virus relate to MAPK signaling in gastric cancer?",{"text":117,"@type":113},"The document highlights that MAPK pathway involvement extends to Helicobacter pylori-mediated gastric carcinogenesis and Epstein-Barr virus-induced tumorigenic processes, indicating molecular crosstalk between pathogens and MAPK-driven biology.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic strategies are discussed for targeting the MAPK pathway?",{"text":121,"@type":113},"The review covers promising therapeutic impacts of herbal medicines, MAPK pathway inhibitors, and immunosuppressants aimed at mitigating gastric cancer progression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329671,1790111410,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Yuan et al. Journal of Translational Medicine (2024) 22:1142  \n[https://doi.org/10.1186/s12967-024-05998-8](https://doi.org/10.1186/s12967-024-05998-8)  \nJournal of Translational Medicine  \n REVIEW Open Access  \nThe role of MAPK pathway in gastric cancer:   unveiling molecular crosstalk and therapeutic prospects  \nWeiwei Yuan1† , Yin Shi2†, Shiping Dai3, Mao Deng3, Kai Zhu3, Yuanmin Xu4, Zhangming Chen4, Zhou Xu1*, Tianlong Zhang5* and Song Liang6*  \nAbstract  \nGastric cancer remains a significant health burden globally, especially prevalent in Asian and European regions. Despite a notable decline in incidence in the United States and Western Europe over recent decades, the disease’s persistence underscores the urgency for advanced research in its pathogenesis and treatment strategies. Central to this pursuit is the exploration of the mitogen-activated protein kinase (MAPK) pathway, a pivotal cellular mechanism implicated in the complex processes of gastric cancer development, including cellular proliferation, invasion, migration, and metastasis. The MAPK or extracellular signal-regulated kinase pathway serves as a crucial conduit for transmitting extracellular signals to elicit intracellular responses, with its signaling cascades subject to alterations due to genetic and epigenetic variations across various diseases, prominently cancer. This review delves into the intricate role of the MAPK signaling pathway in the pathogenesis of gastric cancer, drawing upon the most recent and critical studies that shed light on MAPK pathway alterations as a gateway to the disease. It highlights the pathway’s involvement in Helicobacter pylori-mediated gastric carcinogenesis and the tumorigenic processes induced by the Epstein-Barr virus, showcasing the substantial influence of miRNAs and lncRNAs in modulating gastric cancer’s biological properties through their interaction with the MAPK pathway. Furthermore, the review extends into the therapeutic arena, discussing the promising impacts of herbal medicines, MAPK pathway inhibitors, and immunosuppressants on mitigating gastric cancer’s progression. Through an exhaustive examination of the MAPK pathway’s multifaceted role in gastric cancer, from molecular crosstalks to therapeutic prospects, this review aspires to contribute to the ongoing efforts in understanding and combating this global health challenge, paving the way for novel therapeutic interventions and improved patient outcomes.  \nKeywords Gastric carcinogenesis, Mitogen-activated protein kinase signaling, H. pylori and EBV-induced oncogenesis, miRNAs and lncRNAs, Targeted therapy and molecular inhibitors  \n†Weiwei Yuan andYin Shi contributed equally to this work.  \n*Correspondence:  \nZhou Xu [xuzhou9260@163.com](xuzhou9260@163.com)[ ](xuzhou9260@163.com)Tianlong Zhang [zhangtianlong@zju.edu.cn](zhangtianlong@zju.edu.cn)[ ](zhangtianlong@zju.edu.cn)Song Liang [kyzz-1234567@163.com](kyzz-1234567@163.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of ","cbCaiisGaRIIqBuW","https://ap.wps.com/l/cbCaiisGaRIIqBuW","pdf",3586265,18,"English","# Abstract\n# Background","[{\"question\":\"Why is the MAPK pathway important in gastric cancer?\",\"answer\":\"The review explains that MAPK signaling transmits extracellular cues to intracellular responses and its cascades are altered by genetic and epigenetic variations, driving key malignant behaviors such as proliferation, invasion, migration, and metastasis.\"},{\"question\":\"How do Helicobacter pylori and Epstein-Barr virus relate to MAPK signaling in gastric cancer?\",\"answer\":\"The document highlights that MAPK pathway involvement extends to Helicobacter pylori-mediated gastric carcinogenesis and Epstein-Barr virus-induced tumorigenic processes, indicating molecular crosstalk between pathogens and MAPK-driven biology.\"},{\"question\":\"What therapeutic strategies are discussed for targeting the MAPK pathway?\",\"answer\":\"The review covers promising therapeutic impacts of herbal medicines, MAPK pathway inhibitors, and immunosuppressants aimed at mitigating gastric cancer progression.\"}]","The role of MAPK pathway in gastric cancer - unveiling molecular crosstalk and therapeutic prospects | PDF",1789985150,45]