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The work also assesses NEAT1’s expression and clinical relevance, proposing NEAT1 as a potential therapeutic target and biomarker to predict and overcome chemotherapy resistance, and to support future chemotherapy-sensitizer strategies.",{"@graph":14,"@context":71},[15,34,54],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-role-of-lncrna-neat1-in-human-cancer-chemoresistance/342982/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":48,"encodingFormat":47,"isAccessibleForFree":49,"interactionStatistic":50},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-role-of-lncrna-neat1-in-human-cancer-chemoresistance/342982.png","ImageObject",300,407,{"name":42,"@type":43},"Noah","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-22",true,{"@type":51,"interactionType":52,"userInteractionCount":22},"InteractionCounter",{"@type":53},"ViewAction",{"@type":55,"mainEntity":56},"FAQPage",[57,63,67],{"name":58,"@type":59,"acceptedAnswer":60},"Why is chemotherapy resistance a critical issue in cancer treatment?","Question",{"text":61,"@type":62},"Chemotherapy resistance reduces treatment effectiveness and worsens prognosis, contributing to poor clinical outcomes. 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Cancer Cell International (2024) 24:236  \n[https://doi.org/10.1186/s12935-024-03426-x](https://doi.org/10.1186/s12935-024-03426-x)  \nCancer Cell International  \nREVIEW Open Access  \nThe role of lncRNA NEAT1 chemoresistance  \nin human cancer  \nFeng Long 1†, Xue Li 1†, Jingyu Pan 1, Hailin Ye 1, Cuixia Di2, Yong Huang 1, Jiawei Li 1, Xuan Zhou 1, Huiyi Yi 1, Qiaozhen Huang 1 and Jing Si2*  \nAbstract  \nChemotherapy is currently one of the most effective methods in clinical cancer treatment. However, chemotherapy resistance is an important reason for poor chemotherapy efficacy and prognosis, which has become an urgent problem to be solved in the field of cancer chemotherapy. Therefore, it is very important to deeply study and analyze the mechanism of cancer chemotherapy resistance and its regulatory factors. Long non-coding RNA nuclear paraspeckle assembly transcript 1 (LncRNA NEAT1) has been shown to be closely associated with chemotherapy resistance in cancer. NEAT1 induces cancer cell resistance to chemotherapeutic drugs by regulating cell apoptosis, cell cycle, drug transport and metabolism, DNA damage repair, EMT, autophagy, cancer stem cell characteristics, and metabolic reprogramming. This indicates that NEAT1 may be an important target to overcome chemotherapy resistance and is expected to be a potential biomarker to predict the effect of chemotherapy.  \nThis article summarizes the expression characteristics and clinical characteristics of NEAT1 in different cancers, and deeply discusses the regulatory role of NEAT1 in cancer chemotherapy resistance and related molecular mechanisms, aiming to clarify NEAT1 as a new target to overcome cancer chemotherapy resistance and the feasibility of chemotherapy sensitizers, with a view to providing a potential therapeutic direction for overcoming the dilemma of cancer resistance in the future.  \nKeywords Cancer, Chemotherapy resistance, NEAT1, Mechanism of action  \nIntroduction  \nCancer, as the second leading cause of death in the world, is a serious threat to human health and has become a major public health problem worldwide [1]. The treatment of cancer mainly includes surgical treatment, endocrine therapy, targeted therapy, immunotherapy, radiotherapy and chemotherapy [2]. Chemotherapy is  \n†Feng Long and Xue Li should be considered joint first author  \n*Correspondence: Jing Si [sijing@impcas.ac.cn](sijing@impcas.ac.cn)  \n1School of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, China  \n2Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China  \none of the most effective means of clinical treatment of cancer at present. It can significantly reduce the risk of long-term recurrence of cancer and improve the overall survival and quality of life of patients. It has become the main treatment method for patients with systemic cancer, patients with advanced cancer without surgical indications and patients with recurrent and metastatic cancer [3–5]. However, with the continuous use of chemotherapy drugs, some patients will develop resistance to chemotherapy drugs, resulting in poor chemotherapy effect and poor prognosis, which has become a very difficult scientific problem in the field of cancer chemotherapy. Clinical data show that more than 70% of ovarian cancer patients relapse after receiving continuous chemotherapy for 12–18 months due to drug resistance to  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If mat","cbCaipq3lM1EweRo","https://ap.wps.com/l/cbCaipq3lM1EweRo","pdf",2593447,13,"English","# Introduction\n## Chemotherapy and chemoresistance in cancer\n## LncRNA NEAT1 and its regulatory roles\n## Potential targets for chemotherapy sensitization","[{\"question\":\"Why is chemotherapy resistance a critical issue in cancer treatment?\",\"answer\":\"Chemotherapy resistance reduces treatment effectiveness and worsens prognosis, contributing to poor clinical outcomes. The document highlights it as an urgent problem requiring deeper mechanistic study.\"},{\"question\":\"How does NEAT1 promote chemoresistance in cancer cells?\",\"answer\":\"NEAT1 is described as regulating multiple processes linked to resistance, including apoptosis, cell cycle, drug transport and metabolism, DNA damage repair, EMT, autophagy, cancer stem cell characteristics, and metabolic reprogramming.\"},{\"question\":\"What therapeutic or diagnostic potential does NEAT1 have according to the review?\",\"answer\":\"The review suggests NEAT1 may function as an important target to overcome chemotherapy resistance and could serve as a potential biomarker to predict chemotherapy response.\"}]","The role of lncRNA NEAT1 in human cancer chemoresistance | PDF",1790049238,33]