[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-405534-105":59,"doc-detail-405534-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-role-of-lipid-metabolic-reprogramming-in-tumor-microenvironment","The role of lipid metabolic reprogramming in tumor microenvironment","","Metabolic reprogramming is a defining hallmark of malignant tumors, and lipid metabolic reprogramming strongly shapes cancer progression and therapy outcomes by remodeling the tumor microenvironment (TME). Immunotherapy has transformed treatment for advanced cancers, yet its efficacy depends on the immune microenvironment. This review systematically summarizes how lipid metabolic reprogramming influences lipid handling in tumor and immune cells, evaluates links to cell-death modes such as ferroptosis, and consolidates antitumor strategies that target lipid metabolism to potentially sensitize immunotherapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-lipid-metabolic-reprogramming-in-tumor-microenvironment/405534/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-lipid-metabolic-reprogramming-in-tumor-microenvironment/405534.png","ImageObject",300,407,{"name":92,"@type":93},"Eliana","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is lipid metabolic reprogramming important in malignant tumors?","Question",{"text":112,"@type":113},"It remodels the tumor microenvironment, influencing cancer progression and therapeutic response by reshaping how tumor and immune cells handle lipids.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does lipid metabolic reprogramming relate to immunotherapy outcomes?",{"text":117,"@type":113},"It regulates the immune microenvironment and thus affects how well cancer immunotherapy works, with the goal that targeting lipid reprogramming may sensitize immunotherapy.",{"name":119,"@type":110,"acceptedAnswer":120},"What cell-death mode does the review specifically consider in relation to lipid metabolism?",{"text":121,"@type":113},"The review highlights the effects of various cell death modes, especially ferroptosis, on lipid metabolism.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},405534,1791151010,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","Review  \nIvyspring  \nInternational Publisher  \nTheranostics  \n2023; 13(6): 1774-1808. doi: 10.7150/thno.82920  \nThe role of lipid metabolic reprogramming in tumor microenvironment  \nKai Yang1,2,*, Xiaokun Wang1,*, Chenghu Song1, Zhao He1, Ruixin Wang1, Yongrui Xu1, Guanyu Jiang1, Yuan Wan3,􀀍, Jie Mei2,􀀍, Wenjun Mao1,􀀍  \n1. Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China.  \n2. Department of Oncology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing, 210029, China.  \n3. The Pq Laboratory of BiomeDx/Rx, Department of Biomedical Engineering, Binghamton University, Binghamton 13850, USA.  \n* equal contribution  \n􀀍 Corresponding authors: Wenjun Mao, M.D., Department of Cardiothoracic Surgery, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, No. 299 Qingyang Rd., Wuxi, 214023, [China. E-mail: maowenjun1@njmu.edu.cn. Jie Mei](China. E-mail: maowenjun1@njmu.edu.cn. Jie Mei), M.D., Department of Oncology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, No. 299 Qingyang Rd., Wuxi, 214023, [China. E-mail: meijie1996@njmu.edu.cn. Yuan Wan](China. E-mail: meijie1996@njmu.edu.cn. Yuan Wan), Ph.D., The Pq Laboratory of BiomeDx/Rx, Department of Biomedical Engineering, Binghamton University, No. 65 Murray Hill Rd., Binghamton, 13850, USA. E-mail: [ywan@binghamton.edu](ywan@binghamton.edu)  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [http://ivyspring.com/terms](http://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2023.01.25; Accepted: 2023.03.07; Published: 2023.03.13  \nAbstract  \nMetabolic reprogramming is one of the most important hallmarks of malignant tumors. Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and therapeutic response by remodeling the tumor microenvironment (TME) . In the past few decades, immunotherapy has revolutionized the treatment landscape for advanced cancers. Lipid metabolic reprogramming plays pivotal role in regulating the immune microenvironment and response to cancer immunotherapy. Here, we systematically reviewed the characteristics, mechanism, and role of lipid metabolic reprogramming in tumor and immune cells in the TME, appraised the effects of various cell death modes (specifically ferroptosis) on lipid metabolism, and summarized the antitumor therapies targeting lipid metabolism. Overall, lipid metabolic reprogramming has profound effects on cancer immunotherapy by regulating the immune microenvironment; therefore, targeting lipid metabolic reprogramming may lead to the development of innovative clinical applications including sensitizing immunotherapy.  \nKeywords: lipid metabolic reprogramming; tumor microenvironment; immunotherapy; therapeutic target  \nBackground  \nThe history of drug therapy for malignancies, such as cancer, has developed from chemotherapy to targeted therapy and then to immunotherapy. Currently, immunotherapy is the most promising antitumor treatment [1] . Unlike patients on conventional therapies, those who respond to immunotherapy are more likely to achieve high-quality long-term survival with fewer side effects [2] . The\"immunosurveillance theory\" states that the immune system has a complete surveillance function to distinguish and remove \"non-self\" tumors [3] . The core of tumor immunotherapy is to enhance the antitumor immunity by targeting the cancer-immune cycle. This mainly includes the release and  \npresentation of tumor antigens to activate tumor-associated immune cells, and these antigens are delivered and infiltrated into the tumor tissues to enhance their recognition and subsequent elimination [4] . However, immune escape and immunosuppression reduce the effectiveness of immunotherapy because of abnormal reg","cbCailShUOr80Nhk","https://ap.wps.com/l/cbCailShUOr80Nhk","pdf",4356970,35,"English","# Abstract\n# Keywords\n# Background\n## Drug therapy evolution: chemotherapy to targeted therapy to immunotherapy\n## Tumor immunity frameworks: immunosurveillance and immunoediting theories\n## Metabolic reprogramming and the role of lipid metabolism\n## Lipid classes and connections to metabolic regulation","[{\"question\":\"Why is lipid metabolic reprogramming important in malignant tumors?\",\"answer\":\"It remodels the tumor microenvironment, influencing cancer progression and therapeutic response by reshaping how tumor and immune cells handle lipids.\"},{\"question\":\"How does lipid metabolic reprogramming relate to immunotherapy outcomes?\",\"answer\":\"It regulates the immune microenvironment and thus affects how well cancer immunotherapy works, with the goal that targeting lipid reprogramming may sensitize immunotherapy.\"},{\"question\":\"What cell-death mode does the review specifically consider in relation to lipid metabolism?\",\"answer\":\"The review highlights the effects of various cell death modes, especially ferroptosis, on lipid metabolism.\"}]","The role of lipid metabolic reprogramming in tumor microenvironment | PDF",1790560462,88]