[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332869-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332869-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-role-of-hyaluronan-modification-in-the-etiopathogenesis-of-gastric-cancer","The role of hyaluronan modification in the etiopathogenesis of gastric cancer","","Gastric cancer ranks as the second most common cancer worldwide and is associated with substantial mortality. This study investigates how elevated hyaluronan, an extracellular matrix glycosaminoglycan, may contribute mechanistically to gastric cancer development. Blood from 82 gastric cancer patients and 41 healthy volunteers was analyzed using enzyme-linked immunosorbent assays, and surgical tissues from cancer and control groups were evaluated by Western blot, immunofluorescence, and messenger RNA expression profiling. Results show increased circulating hyaluronan in patients and enhanced tumor necrosis factor-inducible gene 6 messenger RNA in tumor tissue, supporting a possible hyaluronan modification role in disease formation.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-role-of-hyaluronan-modification-in-the-etiopathogenesis-of-gastric-cancer/332869/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-role-of-hyaluronan-modification-in-the-etiopathogenesis-of-gastric-cancer/332869.png","ImageObject",300,407,{"name":42,"@type":43},"Clementine","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main objective of the study on gastric cancer?","Question",{"text":63,"@type":64},"To clarify the role of high hyaluronan levels and their mechanistic contribution to gastric cancer pathobiology.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were hyaluronan levels and tissue-related markers measured?",{"text":68,"@type":64},"Plasma hyaluronan was measured by enzyme-linked immunosorbent assay, while tissue protein and gene expression were assessed using Western blot, immunofluorescence, and messenger RNA analysis.",{"name":70,"@type":61,"acceptedAnswer":71},"What key findings link hyaluronan to gastric cancer?",{"text":72,"@type":64},"Cancer patients showed higher plasma hyaluronan levels than controls, and tumor tissues displayed strong hyaluronan binding signals and increased tumor necrosis factor-inducible gene 6 messenger RNA expression.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332869,1790196373,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":97,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},1374391974564,"https://ap-avatar.wpscdn.com/avatar/14000253aa45c000a9e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779874745381141002","ORIGINAL ARTICLE  \n[https://doi.org/10.1590/1806-9282.20241087](https://doi.org/10.1590/1806-9282.20241087)  \nThe role of hyaluronan modification in the etiopathogenesis of gastric cancer  \nAhmet Turan Durak1 , Hızır Yakup Akyıldız2 , Pınar Altın Çelik3 , Metin Aytekin4*   \nSUMMARY  \nOBJECTIVE: Gastric cancer is the second most common cancer in the world, accounting for 650,000 deaths per year, and is observed in approximately 10% of the patients diagnosed. Extracellular matrix abnormalities have been documented in gastric cancer patients. The aim of our study was to understand the role of high levels of hyaluronan, an extracellular matrix glycosaminoglycan, and its mechanistic role in gastric cancer pathobiology. METHODS: Blood samples were collected from 82 gastric cancer patients and 41 healthy volunteers. Hyaluronan measurements were performed with the help of commercially purchased enzyme-linked immunosorbent assay kits. Gastric cancer (n=27) and healthy (n=29) tissue specimens were obtained after surgery and aliquoted for Western blot, immunofluorescence, and messenger RNA expression analysis.  \nRESULTS: Increased hyaluronan levels were detected in the blood of cancer patients compared to controls [plasma hyaluronan levels mg/dL (mean±SD): gastric cancer (n=82) 549.80± 155. 68, and healthy control (n=41) 27.21±4.95 (p\u003C0 . 044)] . In addition, intense hyaluronan binding protein staining was observed in gastric cancer tissues, while tumor necrosis factor-inducible gene 6 messenger RNA expression was found to be significantly increased in gastric cancer tissues compared to healthy controls [tumor necrosis factor-inducible gene 6 messenger RNA expression: gastric cancer (n=27) 7.09± 1.94 and healthy control (n=29) 3.20±0.67 (p=0 .048)] according to the immunofluorescence staining.  \nCONCLUSION: The high hyaluronan levels in gastric cancer patients and the detection of increased messenger RNA levels of the tumor necrosis factor-inducible gene 6 enzyme in gastric cancer tissue, supporting a possible hyaluronan modification, suggest that this abnormality may have an important role in the formation of gastric cancer.  \nKEYWORDS: Hyaluronan. Gastric cancer. Heavy chain. Extracellular matrix.  \nINTRODUCTION  \nGastric cancer is the second most common type of cancer in the world1. The incidence of gastric cancer is known to increase after the age of 50 years and is reported to be equally prevalent for both sexes at the age of 70 years2.  \nExtracellular matrix (ECM) has important roles in cell proliferation and migration. There are studies showing that some cancer types, including gastric cancer, are associated with ECM abnormalities3. Identifying matrix abnormalities in gastric cancer will help us understand the course of the disease. Hyaluronan (HA), which is a free glycosaminoglycan chain, is also found in the stomach. In addition, it has been reported that the degraded products of HA also stimulate angiogenesis4.  \nThe inter-alpha-inhibitor (IαI) complex, which is a serum protein, consists of a proteoglycan called “bikunin” and two“heavy chain” molecules covalently linked by a chondroitin sulfate chain. It is secreted into the blood in high concentrations by the liver and was first found in urine and serum as a trypsin  \ninhibitor5. The functions of heavy chains connecting to IαI are still not elucidated. It is thought that only three forms of the heavy chain molecule, which has six different types, may be associated with IαI and HA6. Under the cofactor of the tumor necrosis factor-inducible gene 6 (TSG-6) enzyme, these heavy chain molecules form a skeleton by binding to HA, and this structure is known to be involved in the calling ofinflammatory cells7. We believe that HA may be involved in carcinogenesis. If this role is proven, then an alternative method can be developed to prevent the occurrence of the disease by blocking HA production.  \nComparison of HA levels in cancerous and healthy tissues has been studied before at the ","cbCaioQbpaZhv2oz","https://ap.wps.com/l/cbCaioQbpaZhv2oz","pdf",1390533,"English","# Summary\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Methods\n## Collection and storage of blood and tissue samples","[{\"question\":\"What is the main objective of the study on gastric cancer?\",\"answer\":\"To clarify the role of high hyaluronan levels and their mechanistic contribution to gastric cancer pathobiology.\"},{\"question\":\"How were hyaluronan levels and tissue-related markers measured?\",\"answer\":\"Plasma hyaluronan was measured by enzyme-linked immunosorbent assay, while tissue protein and gene expression were assessed using Western blot, immunofluorescence, and messenger RNA analysis.\"},{\"question\":\"What key findings link hyaluronan to gastric cancer?\",\"answer\":\"Cancer patients showed higher plasma hyaluronan levels than controls, and tumor tissues displayed strong hyaluronan binding signals and increased tumor necrosis factor-inducible gene 6 messenger RNA expression.\"}]","The role of hyaluronan modification in the etiopathogenesis of gastric cancer | PDF",1789999799,13]