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This retrospective case-control study evaluated whether the GPX1 gene polymorphism rs1050450 is associated with ovarian cancer susceptibility in a Turkish population, using real-time PCR genotyping. Among 90 patients and 90 controls, the CC genotype reduced risk, while TT and the T allele increased risk. Findings suggest GPX1 variants may serve as risk markers, pending larger validation studies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-gpx1-rs1050450-variants-in-ovarian-cancer-susceptibility-within-a-turkish-population/365315/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-gpx1-rs1050450-variants-in-ovarian-cancer-susceptibility-within-a-turkish-population/365315.png","ImageObject",300,407,{"name":92,"@type":93},"Jake","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-26","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the objective of this study?","Question",{"text":112,"@type":113},"To examine the association between the GPX1 (rs1050450) polymorphism and ovarian cancer risk in a Turkish population.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was rs1050450 genotyped?",{"text":117,"@type":113},"The study used real-time PCR (RT-PCR) to perform genotyping of the GPX1 (rs1050450) polymorphism.",{"name":119,"@type":110,"acceptedAnswer":120},"Which GPX1 rs1050450 genotypes were linked to ovarian cancer susceptibility?",{"text":121,"@type":113},"The CC genotype was associated with a reduced risk, whereas the TT genotype and the T allele were linked to increased risk.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},365315,1790196375,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962084928904,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","| The Role of GPX1 (rs1050450) Variants in Ovarian Cancer Susceptibility Within a Turkish Population | Cancer Control Volume 32: 1–10 © The Author(s) 2025 Article reuse guidelines:\u003Cbr>[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/10732748251332441](DOI: 10.1177/10732748251332441)\u003Cbr>[journals.sagepub.com/home/ccx](journals.sagepub.com/home/ccx)\u003Cbr>\u003Cbr>|\n| --- | --- |\n| Baker Alsheikh, PhD 1 􀀁, Rukset Attar, MD, PhD2, Seda Güleç Yilmaz, PhD3, Sara Yaser Barham4, and Selvi Duman Bakırezer, PhD5\u003Cbr>Abstract\u003Cbr>Introduction: Ovarian cancer (OC) remains one of the most lethal gynecological malignancies, primarily due to challenges in early detection and the consequent poor prognosis. Genetic predisposition plays a critical role in OC development, with the Glutathione Peroxidase 1 (GPX1) gene receiving increasing attention. The GPX1 gene polymorphism rs1050450 has been implicated in various cancers, potentially through its impact on oxidative stress mechanisms.\u003Cbr>Objective: This study aimed to investigate the association between the GPX1 (rs1050450) polymorphism and the risk of developing OC in a Turkish population.\u003Cbr>Methods: A retrospective case-control study was conducted involving 90 women diagnosed with OC and 90 healthy controls. Genotyping of the GPX1 (rs1050450) polymorphism was performed using real-time PCR (RT-PCR). Statistical analyses were conducted using the SPSS software, with chi-square and t-tests applied where appropriate.\u003Cbr>Results: The CC genotype of the GPX1 (rs1050450) polymorphism was significantly associated with a reduced risk of OC (P = 0.002; OR = 0.304; 95% CI = 0.161-0.577), whereas the TT genotype was linked to an increased risk, demonstrating a threefold elevation in susceptibility (P = 0.036; OR = 3.308; 95% CI = 1.024-10.682). Additionally, the T allele was associated with an approximately threefold increased risk of developing OC (P = 0.0002).\u003Cbr>Conclusion: These findings suggest that the GPX1 (rs1050450) polymorphism may play a significant role in OC susceptibility, with the CC genotype offering potential protective effects and the TT genotype indicating increased risk. This genetic variant may serve as a useful marker for assessing OC risk; however, further studies involving larger and more diverse populations are needed to validate these results.\u003Cbr>Plain Language Summary\u003Cbr>Ovarian cancer (OC) is one of the deadliest gynecological cancers, largely due to its late diagnosis and poor prognosis. Several factors contribute to the development of OC, including genetic susceptibility. Glutathione Peroxidase 1 (GPX1) is an important antioxidant enzyme that protects cells from oxidative stress, which can damage DNA and contribute to cancer development. However, the role of GPX1 in ovarian cancer remains unclear, as it may either suppress or promote tumor growth depending on the context. A specific genetic variation in the GPX1 gene, known as rs1050450, has been linked to the risk of several types of cancer. In this study, we investigated whether this genetic variant is associated with an increased or decreased risk of ovarian |  |\n| 1 Department of Molecular Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey\u003Cbr>2Department of Obstetrics and Gynecology, Faculty of Medicine, Yeditepe University Hospital, Yeditepe University, Istanbul, Turkey 3Department of Medical Biology, Faculty of Medicine, Yeditepe University Hospital, Yeditepe University, Istanbul, Turkey 4Pharmaceutical Sciences, University of Strathclyde, Glasgow, UK\u003Cbr>5Faculty of Medicine, Yeditepe University Hospital, Yeditepe University, Istanbul, Turkey\u003Cbr>Corresponding Author:\u003Cbr>Baker Alsheikh, Department of Molecular Medicine, Faculty of Medicine, Yeditepe University, Kayıda˘gı, ˙Innü Mahallesi, Kayıda˘gı Cd., Ataehir/˙Istanbul 34755, Turkey.\u003Cbr>Email: [bakermohammadamro.alsheikh@std.yeditepe.edu.tr](bakermohammadamro.alsheikh@std.yeditepe.edu.tr) |  |\n","cbCaifE3005N2kxG","https://ap.wps.com/l/cbCaifE3005N2kxG","pdf",901250,"English","# Abstract\n# Introduction and Purpose\n# Glutathione Peroxidase 1 (GPX1) and Rationale\n# Objective\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What was the objective of this study?\",\"answer\":\"To examine the association between the GPX1 (rs1050450) polymorphism and ovarian cancer risk in a Turkish population.\"},{\"question\":\"How was rs1050450 genotyped?\",\"answer\":\"The study used real-time PCR (RT-PCR) to perform genotyping of the GPX1 (rs1050450) polymorphism.\"},{\"question\":\"Which GPX1 rs1050450 genotypes were linked to ovarian cancer susceptibility?\",\"answer\":\"The CC genotype was associated with a reduced risk, whereas the TT genotype and the T allele were linked to increased risk.\"}]","The Role of GPX1 (rs1050450) Variants in Ovarian Cancer Susceptibility Within a Turkish Population | PDF",1790160634,25]