[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-366901-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-366901-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-role-of-cstf2-in-gastric-cancer-implications-for-therapy","The role of CSTF2 in gastric cancer - implications for therapy","","Gastric cancer is a lethal malignancy often diagnosed at advanced stages, with limited effective treatments. This study investigates whether the RNA-binding protein CSTF2 influences gastric cancer biology and patient outcomes. Gastric tumor and adjacent tissues were analyzed for CSTF2 levels, and CSTF2 knockdown in cell models assessed effects on proliferation, migration, and invasion. Mechanistically, CSTF2 controls TGM2 mRNA stability, and TGM2 overexpression partially restores CSTF2-loss inhibition. CSTF2 correlates with poor prognosis and suggests a therapeutic target.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-role-of-cstf2-in-gastric-cancer-implications-for-therapy/366901/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-role-of-cstf2-in-gastric-cancer-implications-for-therapy/366901.png","ImageObject",300,407,{"name":42,"@type":43},"hdkawk","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is CSTF2, and why study it in gastric cancer?","Question",{"text":63,"@type":64},"CSTF2 is an RNA-binding protein linked to prognosis in several cancers. 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CSTF2 knockdown accelerates TGM2 mRNA decay, and restoring TGM2 partially rescues inhibited proliferation and colony formation.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},366901,1790342293,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},3985747859855,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Feng et al. European Journal  \nEuropean Journal of Medical Research (2025) 30:1304  \n[https://doi.org/10.1186/s40001-025-03570-8](https://doi.org/10.1186/s40001-025-03570-8 of Medical Research)[ of Medical Research](https://doi.org/10.1186/s40001-025-03570-8 of Medical Research)  \n RESEARCH Open Access  \nThe role of CSTF2 in gastric cancer: implications for therapy  \nLiang Feng1†, Zhiguo Cao2†, Xiaoqi Shi3†, Wenhao Liu1, Weiwei Xu1, Changjun Yu1, Jie Ning4* and Changyu Chen1*  \nAbstract  \nBackground Gastric cancer is a fatal malignancy that is frequently diagnosed at an advanced stage worldwide, and current treatments are limited. The RNA-binding protein CSTF2 is associated with the prognosis of many cancers, but the role it plays in gastric cancer remains unknown.  \nMethods We collected tissues of gastric cancer and adjacent ones paired adjacent non-tumor tissues at the First Affiliated Hospital of Anhui Medical University. CSTF2 expression was initially detected using immunohistochemistry and Western blotting, and its association with clinicopathological features was assessed. Knockdown of CSTF2 in gastric carcinoma cell models was conducted to examine the effect on cell proliferation, migration, and invasion. The mRNA stability of downstream targets was assessed by actinomycin D assay. Further RNA sequencing analysis revealed the downstream influential genes of CSTF2, especially TGM2 . Afterwards, the function ofTGM2 and its interactions with CSTF2 were further verified.  \nResults The production of CSTF2 was markedly higher in gastric cancer tissues compared to adjacent noncancerous tissues and showed a strong correlation with poor patient prognosis. CSTF2 inhibition significantly suppressed gastric cancer cell growth, proliferation, migration, and invasion. Mechanistically, CSTF2 knockdown accelerated the decay ofTGM2 mRNA, indicating that CSTF2 post-transcriptionally stabilizesTGM2 transcripts. Further gene expression analysis revealed that TGM2 might serve as a key downstream effector of CSTF2 . Ectopic expression ofTGM2 partially rescued the inhibitory effect of CSTF2 deficiency on cell proliferation and colony formation.  \nConclusions CSTF2 promotes gastric cancer progression by post-transcriptionally stabilizing TGM2 mRNA, and its overexpression is closely related to poor prognosis. The elucidated CSTF2–TGM2 regulatory axis may offer a promising and innovative therapeutic target for gastric carcinoma treatment.  \nKeywords CSTF2, Gastric cancer, TGM2, RNA-binding protein  \n† Liang Feng, Zhiguo Cao, and Xiaoqi Shi are contributed equally to this work.  \n*Correspondence: Jie Ning [nj830921@126.com](nj830921@126.com)[ ](nj830921@126.com)Changyu Chen  \n[chenchangyu1987@163.com](chenchangyu1987@163.com)  \n1 Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei 230022, Anhui, China  \n2 Department of General Surgery, The Second People’s Hospital of Lu’an, Lu’an 237000, Anhui, China  \n3 Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei 230022, Anhui, China  \n4 Department of Oncology, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei 230022, Anhui, China  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If materi","cbCainUxy4of8jmX","https://ap.wps.com/l/cbCainUxy4of8jmX","pdf",3030389,13,"English","# Introduction\n## Background and unmet clinical needs\n## Current treatment landscape and challenges\n# Abstract\n## Background\n## Methods\n## Results\n## Conclusions","[{\"question\":\"What is CSTF2, and why study it in gastric cancer?\",\"answer\":\"CSTF2 is an RNA-binding protein linked to prognosis in several cancers. Its specific role in gastric cancer was previously unknown.\"},{\"question\":\"How was CSTF2 expression measured and related to clinical features?\",\"answer\":\"CSTF2 expression was detected in paired gastric tumor and adjacent non-tumor tissues using immunohistochemistry and Western blotting, and associations with clinicopathological features and prognosis were assessed.\"},{\"question\":\"What mechanism connects CSTF2 to gastric cancer progression?\",\"answer\":\"CSTF2 promotes progression by post-transcriptionally stabilizing TGM2 mRNA. CSTF2 knockdown accelerates TGM2 mRNA decay, and restoring TGM2 partially rescues inhibited proliferation and colony formation.\"}]","The role of CSTF2 in gastric cancer - implications for therapy | PDF",1790168168,33]