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Method: Systematically reviewed articles from 2013 to 2024 across five major databases, applying inclusion criteria for gastric cancer cell-line studies and andrographolide extraction or standard treatment; non-matching languages, reviews, and non-primary formats were excluded. Result: 93 records yielded six relevant studies. Conclusion: Findings indicate andrographolide can inhibit the cell cycle, suppress proliferation, reduce oxidative stress, and trigger apoptosis to limit gastric cancer growth.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-role-of-andrographolide-as-a-potential-anticancer-agent-against-gastric-cancer-cell-lines-a-systematic-review/331553/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-role-of-andrographolide-as-a-potential-anticancer-agent-against-gastric-cancer-cell-lines-a-systematic-review/331553.png","ImageObject",300,407,{"name":92,"@type":93},"Seraphina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study’s main objective regarding andrographolide?","Question",{"text":112,"@type":113},"The study aims to critically analyse literature on andrographolide’s anticancer properties in in vitro experiments using gastric cancer cells.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which studies were included or excluded in the systematic review?",{"text":117,"@type":113},"Included studies assessed andrographolide in gastric cancer cell lines using extracted andrographolide from Andrographis paniculata or standard andrographolide sources. Excluded were studies in different languages and non-primary formats such as review articles, book chapters, conference articles, and scientific reports.",{"name":119,"@type":110,"acceptedAnswer":120},"What anticancer effects do the selected studies report for andrographolide?",{"text":121,"@type":113},"The studies suggest andrographolide can hinder the cell cycle, suppress proliferation, alleviate oxidative stress, and induce apoptosis in gastric cancer cells.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331553,1791696386,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},962075114101,"https://ap-avatar.wpscdn.com/avatar/e000253a75eb197efd?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780044092746381165","Submitted 25 June 2024  \nAccepted 21 October 2024 Published 20 November 2024  \nCorresponding author Tuan Noorkorina Tuan Kub, [tnkorina@gmail.com](tnkorina@gmail.com)  \nAcademic editor Liang Wang  \nAdditional Information and Declarations can be found on page 14  \nDOI 10.7717/peerj.18513 Copyright  \n2024 Anis Amiera et al.  \nDistributed under  \nCreative Commons CC-BY 4.0  \nThe role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review  \nMuhamad Alojid Anis Amiera 1, Tuan Noorkorina Tuan Kub 1, Azian Harun 1, Rohimah Mohamud2, Nur Rina Alissa Razian 1, Yasmin Khairani Muhammad Ismadi 1, Wan AlifSyazwani Wan Alias 1, Mohammed Hussain Abdulrazak1 and Ernawati Teni3  \n1 Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia  \n2 Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia  \n3 National Research and Innovation Agency (BRIN), Research Centre for Pharmaceutical Ingredients and Traditional Medicines, Yogjakarta, Indonesia  \nABSTRACT  \nObjective: To critically analyse literature on the anticancer properties of  \nandrographolide in in vitro studies on gastric cancer cells.  \nMethod: This study systematically reviewed articles from 2013 to 2024 across five prominent databases; PubMed, Google Scholar, Web of Science, Scopus, and Science Direct, EMBASE, Cochrane library and DOAJ. The study eligibility criteria include original studies assessing using gastric cancer cell lines and articles utilizing extracted andrographolide from Andrographis paniculata or standard andrographolide source treatment. The following exclusion criteria were articles written in a different language, review articles, book chapters, conference articles, scientific reports.  \nDuplicated articles were removed using Mendeley software.  \nResult: Out of 93 articles, six were relevant, primarily focusing on in vitro analyses with gastric adenocarcinoma cell lines.  \nConclusion: These studies indicate that andrographolide can hinder the cell cycle, suppress cell proliferation, alleviate oxidative stress, and induce apoptosis by prompting gastric cancer cells to undergo self-destruction, which is a crucial mechanism for controlling and eliminating cancerous growths.  \nSubjects Cell Biology, Microbiology, Immunology, Pharmacology  \nKeywords Andrographis paniculata, Andrographolide, In vitro, Gastric cancer cell lines, Anticancer INTRODUCTION  \nCancer poses a significant global public health challenge. According to the International Agency for Research on Cancer, the number of cancer patients worldwide is projected to reach 28.4 million by 2040, a 47% increase from 2020, solidifying its position as one of the leading causes of death (Hu et al., 2024) . Among all cancer types, gastric cancer ranks fifthin global diagnoses and is the third leading cause of cancer-related deaths, accounting for over a million new cases annually. It carries particularly high mortality rates in regions such as South America, Eastern Europe, and East Asia (Smyth et al., 2020;  \nHow to cite this article Anis Amiera MA, Tuan Kub TN, Harun A, Mohamud R, Razian NRA, Muhammad Ismadi YK, Wan Alias WAS, Abdulrazak MH, Teni E. 2024. The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic  \nreview. PeerJ 12:e18513 DOI 10.7717/peerj.18513  \nBray et al., 2018) . Gastric cancer, commonly known as stomach cancer, arises from the stomach lining and often progresses without early symptoms, making early detection challenging. Key risk factors include Helicobacter pylori infection, dietary choices, smoking, and genetic susceptibility (Mamun, Younus & Rahman, 2024) . The prognosis for gastric cancer remains poor, especially in cases diagnosed at later stages. With the high hospital burden, severe oncological and surgical resource constraints, chemotherapy treatment is only","cbCaioqa3c609KBU","https://ap.wps.com/l/cbCaioqa3c609KBU","pdf",5537401,16,"English","# Abstract\n## Objective\n## Method\n## Result\n## Conclusion\n# Introduction","[{\"question\":\"What is the study’s main objective regarding andrographolide?\",\"answer\":\"The study aims to critically analyse literature on andrographolide’s anticancer properties in in vitro experiments using gastric cancer cells.\"},{\"question\":\"Which studies were included or excluded in the systematic review?\",\"answer\":\"Included studies assessed andrographolide in gastric cancer cell lines using extracted andrographolide from Andrographis paniculata or standard andrographolide sources. Excluded were studies in different languages and non-primary formats such as review articles, book chapters, conference articles, and scientific reports.\"},{\"question\":\"What anticancer effects do the selected studies report for andrographolide?\",\"answer\":\"The studies suggest andrographolide can hinder the cell cycle, suppress proliferation, alleviate oxidative stress, and induce apoptosis in gastric cancer cells.\"}]","The role of andrographolide as a potential anticancer agent against gastric cancer cell lines - a systematic review | PDF",1789993954]