[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-415362-en":59,"doc-seo-415362-105":80},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":72,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":72,"language":73,"language_code":74,"site_id":75,"html_lang":74,"table_of_contents":76,"faqs":77,"seo_title":78,"seo_description":66,"update_tm":79,"read_time":41,"preview_page_count":4},415362,962084926284,"Aria Callaghan","https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","The role of Akkermansia muciniphila in the regulation of inflammatory bowel disease: intestinal immunity and metabolism - Review","Inflammatory bowel disease (IBD) is closely associated with Akkermansia muciniphila, a resident gut bacterium being developed as a next-generation probiotic. Accumulated evidence indicates that live and pasteurized A. muciniphila, along with its components and secretions, can protect and ameliorate IBD. However, the regulatory mechanisms remain insufficiently understood, limiting insights into IBD etiology and targeted therapies.","TYPE Review  \nPUBLISHED 19 December 2025 DOI 10.3389/fimmu.2025.1653472  \nOPEN ACCESS  \nEDITED BY  \nSilvia Turroni,  \nUniversity of Bologna, Italy  \nREVIEWED BY  \nZhiming Li,  \nBeijing Genomics Institute (BGI), China Jefferson Elias-Oliveira,  \nUniversidade Federal de Jata (UFJ), Brazil  \n*CORRESPONDENCE  \nShufa Zheng  \n [zsfzheng@zju.edu.cn](zsfzheng@zju.edu.cn)[ ](zsfzheng@zju.edu.cn)Nanping Wu  \n [wunanping@jnl.ac.cn](wunanping@jnl.ac.cn)  \nRECEIVED 25 June 2025  \nREVISED 04 November 2025  \nACCEPTED 08 December 2025  \nPUBLISHED 19 December 2025  \nCITATION  \nXu W, Li A, Jing H, Zhang X, Dong X, Song Z, Wu N and Zheng S (2025) The role of Akkermansia muciniphila in the regulation of inflammatory bowel disease: intestinal immunity and metabolism.  \nFront. Immunol. 16:1653472 .  \ndoi: 10.3389/fimmu.2025.1653472  \nCOPYRIGHT  \n© 2025 Xu, Li, Jing, Zhang, Dong, Song, Wu and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nThe role of Akkermansiamuciniphila in the regulation of inflammatory bowel disease: intestinal immunity and metabolism  \nWang Xu 1, Aijing Li 1, Huijuan Jing 1, Xiaoping Zhang 1, Xucheng Dong 1, Zhiqiang Song 1, Nanping Wu 1,2* and Shufa Zheng 1,2*  \n1Jinan Microecological Biomedicine Shandong Laboratory, Jinan, China, 2State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China  \nInflammatory bowel disease (IBD) is closely associated with the abundance of Akkermansia muciniphila (A. muciniphila), a resident member of the intestinal tract that is being developed as a next-generation probiotic. Accumulated evidence has indicated that the live and pasteurized A. muciniphila, as well as its components and secretions, have exhibited protective and ameliorative functions in IBD. Nevertheless, the precise and intricate regulatory mechanisms of A. muciniphilain IBD remain unclear, which is crucial for investigating the etiology of IBD and searching for innovative, targeted therapeutic strategies. In this review, we discuss the reciprocal influence between A. muciniphila and intestinal immunity in IBD, encompassing the roles of immune cells, intestinal epithelial cells (IECs), and intestinal stem cells (ISCs) . Subsequently, we outline the mutual regulatory interactions between A. muciniphila and intestinal metabolism, focusing on tryptophan (Trp) metabolism, short-chain fatty acids (SCFAs) metabolism, and bile acids (BAs) metabolism. Understanding how A. muciniphila interacts with its host is a vital step for facilitating its application in IBD therapy.  \nKEYWORDS  \nAkkermansia muciniphila, inflammatory bowel disease, gut microbiota, intestinal immunity, immune cells, metabolism  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \n1 Introduction  \nThe IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disease driven by inappropriate intestinal immune activation. The etiology of IBD is complex and multifactorial, primarily involving genetic and environmental factors, which perturb the homeostasis between the gut microbiome and the host immune system (Figure 1) (1, 2). The burden of IBD across the globe is still considerable (3) . Patients with IBD have an increased risk of colorectal cancer, which is the third most common cancer in the world (9.6% of all cancers globally) (4–6) . Convent","cbCaiviP1wysV73R","https://ap.wps.com/l/cbCaiviP1wysV73R","pdf",1107110,12,"English","en",105,"# Introduction\n## Akkermansia muciniphila and IBD link\n## Regulatory mechanisms and therapeutic potential\n# Intestinal immunity and metabolism interplay","[{\"question\":\"What is the relationship between Akkermansia muciniphila and inflammatory bowel disease?\",\"answer\":\"IBD is closely associated with the abundance of Akkermansia muciniphila. Evidence links altered A. muciniphila levels with IBD in patients and model mice compared with healthy controls.\"},{\"question\":\"How might Akkermansia muciniphila affect IBD according to this review?\",\"answer\":\"The review discusses reciprocal influence between A. muciniphila and intestinal immunity in IBD, including immune cells, intestinal epithelial cells, and intestinal stem cells.\"},{\"question\":\"Which metabolic pathways are emphasized for Akkermansia muciniphila in IBD?\",\"answer\":\"The review outlines mutual regulation between A. muciniphila and intestinal metabolism, focusing on tryptophan metabolism, short-chain fatty acid metabolism, and bile acid metabolism.\"}]","The role of Akkermansia muciniphila in the regulation of inflammatory bowel disease: intestinal immunity and metabolism - Review | PDF",1790601117,{"code":4,"msg":81,"data":82},"ok",{"site_id":75,"language":74,"slug":83,"title":65,"keywords":84,"description":66,"schema_data":85,"social_meta":139,"head_meta":141,"extra_data":143,"updated_unix":144},"the-role-of-akkermansia-muciniphila-in-the-regulation-of-inflammatory-bowel-disease-intestinal-immunity-and-metabolism-review","",{"@graph":86,"@context":138},[87,101,121],{"@type":88,"itemListElement":89},"BreadcrumbList",[90,94,96,99],{"item":91,"name":92,"@type":93,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":95,"name":9,"@type":93,"position":14},"https://docshare.wps.com/document/",{"item":97,"name":35,"@type":93,"position":98},"https://docshare.wps.com/document/healthcare/",3,{"item":100,"name":65,"@type":93,"position":19},"https://docshare.wps.com/document/the-role-of-akkermansia-muciniphila-in-the-regulation-of-inflammatory-bowel-disease-intestinal-immunity-and-metabolism-review/415362/",{"url":100,"name":65,"@type":102,"image":103,"author":108,"headline":65,"publisher":110,"fileFormat":113,"inLanguage":74,"description":66,"dateModified":114,"datePublished":115,"encodingFormat":113,"isAccessibleForFree":116,"interactionStatistic":117},"DigitalDocument",{"url":104,"@type":105,"width":106,"height":107},"https://docshare.wps.com/thumbnails/the-role-of-akkermansia-muciniphila-in-the-regulation-of-inflammatory-bowel-disease-intestinal-immunity-and-metabolism-review/415362.png","ImageObject",300,407,{"name":63,"@type":109},"Person",{"url":91,"name":111,"@type":112},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":118,"interactionType":119,"userInteractionCount":72},"InteractionCounter",{"@type":120},"ViewAction",{"@type":122,"mainEntity":123},"FAQPage",[124,130,134],{"name":125,"@type":126,"acceptedAnswer":127},"What is the relationship between Akkermansia muciniphila and inflammatory bowel disease?","Question",{"text":128,"@type":129},"IBD is closely associated with the abundance of Akkermansia muciniphila. Evidence links altered A. muciniphila levels with IBD in patients and model mice compared with healthy controls.","Answer",{"name":131,"@type":126,"acceptedAnswer":132},"How might Akkermansia muciniphila affect IBD according to this review?",{"text":133,"@type":129},"The review discusses reciprocal influence between A. muciniphila and intestinal immunity in IBD, including immune cells, intestinal epithelial cells, and intestinal stem cells.",{"name":135,"@type":126,"acceptedAnswer":136},"Which metabolic pathways are emphasized for Akkermansia muciniphila in IBD?",{"text":137,"@type":129},"The review outlines mutual regulation between A. muciniphila and intestinal metabolism, focusing on tryptophan metabolism, short-chain fatty acid metabolism, and bile acid metabolism.","https://schema.org",{"og:url":100,"og:type":140,"og:title":65,"og:site_name":111,"og:description":66},"article",{"robots":142,"canonical":100},"index,follow",{"doc_id":61,"site_id":75},1790806507]