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It summarizes evidence on incidence, histologic patterns, diagnostic limitations of preoperative imaging, and resulting management implications. Studies show neoplasm rates below 2% in uncomplicated cases, but 10–15% in abscess-complicated cohorts, with diagnosis often incidental on postoperative histopathology. Age is the strongest predictor, with notable risk above 35–40 years.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-risk-of-neoplasms-in-appendiceal-abscess-what-emergency-surgeons-should-know/360115/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-risk-of-neoplasms-in-appendiceal-abscess-what-emergency-surgeons-should-know/360115.png","ImageObject",300,407,{"name":92,"@type":93},"Chumphorn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does the risk of appendiceal neoplasms differ between uncomplicated and abscess-complicated acute appendicitis?","Question",{"text":113,"@type":114},"The review reports a low incidence in uncomplicated acute appendicitis, generally below 2%. In contrast, appendicitis complicated by periappendiceal abscess shows substantially higher neoplasm rates, reaching about 10–15% in population-based cohorts and selected interval appendectomy series.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why can preoperative imaging fail to reliably detect tumors in patients with periappendiceal abscess?",{"text":118,"@type":114},"Because preoperative imaging has limited accuracy for tumor detection, the optimal management strategy remains debated. As a result, most tumors are diagnosed incidentally on postoperative histopathology.",{"name":120,"@type":111,"acceptedAnswer":121},"What management approach does the review support for older adults with appendiceal abscess?",{"text":122,"@type":114},"It concludes that interval appendectomy after successful non-operative management provides diagnostic certainty and oncologic safety in adults aged 35 years or older, where the risk of underlying neoplasia is clinically relevant.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},360115,1790640506,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},2336475401981,"https://ap-avatar.wpscdn.com/avatar/22000c94efd8d5204d?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786935347598174694","TYPE Review  \nPUBLISHED 04 May 2026  \nDOI 10.3389/fonc.2026.1767622  \nOPEN ACCESS  \nEDITED BY  \nJuan Jose´ Segura-Sampedro, University Hospital La Paz, Spain  \nREVIEWED BY  \nFulvio Tagliabue,  \nAlessandro Manzoni Hospital, Italy Carlos Armando Navarro Castañeda, Hospital Angeles Acoxpa, Mexico  \n*CORRESPONDENCE  \nMauro Podda  \n [mauropodda@ymail.com](mauropodda@ymail.com)  \nRECEIVED 14 December 2025  \nREVISED 04 March 2026  \nACCEPTED 17 March 2026  \nPUBLISHED 04 May 2026  \nCITATION  \nMontori G, Podda M, Giordano A, Procida G, Butera V, Murzi V,  \nFugazzola P, Bergamini C, Catena F, Ansaloni L, Pisanu A and Agresta F (2026)  \nThe risk of neoplasms in appendiceal abscess: what emergency surgeons should know.  \nFront. Oncol. 16:1767622 .  \ndoi: 10.3389/fonc.2026.1767622  \nCOPYRIGHT  \n© 2026 Montori, Podda, Giordano, Procida, Butera, Murzi, Fugazzola, Bergamini, Catena, Ansaloni, Pisanu and Agresta. This is an open-access article distributed under the terms of the  \nCreative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nThe risk of neoplasms in appendiceal abscess:  \nwhat emergency surgeons should know  \nGiulia Montori 1, Mauro Podda 2*, Alessio Giordano 3, Giuseppa Procida 1, Vittoria Butera 1, Valentina Murzi 2, Paola Fugazzola 4, Carlo Bergamini 3, Fausto Catena 5, Luca Ansaloni 4, Adolfo Pisanu 2 and Ferdinando Agresta 1  \n1 Department of General Surgery, Ulss2 Marca Trevigiana, Vittorio Veneto, Treviso, Italy, 2 Department of Surgical Science, University of Cagliari, Cagliari, Italy, 3 Emergency Surgery Unit, Careggi University Hospital, Florence, Italy, 4 Department of Clinical, Surgical, Diagnostic & Pediatric Sciences, University of Pavia, Pavia, Italy, 5 Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy  \nIntroduction: A subset of patients with acute appendicitis presents with complicated disease characterized by periappendiceal abscess . Although appendiceal neoplasms are rare in uncomplicated appendicitis, recent evidence suggests a higher incidence in patients with appendicitis complicated by abscess, particularly in older adults. Because preoperative imaging has limited accuracy for tumor detection, the optimal management strategy remains debated. This narrative review summarizes current evidence on the incidence, histology, diagnostic limitations, and management implications of appendiceal neoplasms in patients with appendiceal abscess.  \nMethods: A literature search was conducted in MEDLINE (PubMed) and the Cochrane Central Register of Controlled Trials from inception to November 2025. Eligible studies included randomized controlled trials, prospective and retrospective cohort studies, and case–control studies addressing complicated acute appendicitis with periappendiceal abscess and the incidence or characteristics of appendiceal neoplasms. Data were synthesized qualitatively through a narrative approach.  \nResults: Primary studies show a low incidence of appendiceal neoplasms in uncomplicated acute appendicitis, generally below 2% . Patients with appendicitis complicated by periappendiceal abscess demonstrate substantially higher neoplasm rates, reaching 10–15% in population-based cohorts and selected interval appendectomy series. Most tumors are diagnosed incidentallyon postoperative histopathology. Neuroendocrine tumors are more frequently identified in patients with uncomplicated acute appendicitis, whereas low-grade appendiceal mucinous neoplasms predominate in cases complicated by periappendiceal abscess. Invasive adenocarcinoma is also reported across both clinical presentations, with a higher prevalence in older patients. Age is t","cbCaiaWCiL8PmYe2","https://ap.wps.com/l/cbCaiaWCiL8PmYe2","pdf",664176,11,"English","# Introduction\n# Methods\n# Results\n# Conclusions","[{\"question\":\"How does the risk of appendiceal neoplasms differ between uncomplicated and abscess-complicated acute appendicitis?\",\"answer\":\"The review reports a low incidence in uncomplicated acute appendicitis, generally below 2%. In contrast, appendicitis complicated by periappendiceal abscess shows substantially higher neoplasm rates, reaching about 10–15% in population-based cohorts and selected interval appendectomy series.\"},{\"question\":\"Why can preoperative imaging fail to reliably detect tumors in patients with periappendiceal abscess?\",\"answer\":\"Because preoperative imaging has limited accuracy for tumor detection, the optimal management strategy remains debated. As a result, most tumors are diagnosed incidentally on postoperative histopathology.\"},{\"question\":\"What management approach does the review support for older adults with appendiceal abscess?\",\"answer\":\"It concludes that interval appendectomy after successful non-operative management provides diagnostic certainty and oncologic safety in adults aged 35 years or older, where the risk of underlying neoplasia is clinically relevant.\"}]","The risk of neoplasms in appendiceal abscess - what emergency surgeons should know | PDF",1790138779,28]