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Methods: Retrospective cohort of women with FIGO 2009 IB cervical cancer meeting inclusion criteria, treated by radical hysterectomy and pelvic lymphadenectomy (1985–2020); expert pathologists revised specimens; logistic regression calculated odds ratios. Results: 10/389 had confirmed LNM (2.6%); LNM associated with LVSI, not with clinical visibility. Conclusion: Consider pelvic lymph node assessment when DOI >3 mm and/or LVSI is present.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-risk-of-lymph-node-metastasis-in-the-new-figo-2018-stage-ia-cervical-cancer-with-7-mm-diameter-original-article/380601/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-risk-of-lymph-node-metastasis-in-the-new-figo-2018-stage-ia-cervical-cancer-with-7-mm-diameter-original-article/380601.png","ImageObject",300,407,{"name":92,"@type":93},"Aran","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What patient group was analyzed in this study?","Question",{"text":113,"@type":114},"Women with cervical cancer classified as FIGO 2018 stage IA defined by ≤5 mm depth of invasion (DOI) and tumor diameter >7 mm.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How often did lymph node metastasis occur?",{"text":118,"@type":114},"Among 389 included patients, 10 had pathologically confirmed LNM, for an incidence of 2.6% (95% CI 1.3%–4.5%).",{"name":120,"@type":111,"acceptedAnswer":121},"Which factors were associated with lymph node metastasis?",{"text":122,"@type":114},"LNM risk increased with lymphovascular space invasion (LVSI) in univariate analysis, while no difference in LNM was found between microscopy-diagnosed lesions and clinically visible lesions.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},380601,1790649198,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},137455076865,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","J Gynecol Oncol. 2023 Nov;34(6):e75 [https://doi.org/10.3802/jgo.2023.34.e75](https://doi.org/10.3802/jgo.2023.34.e75)[ ](https://doi.org/10.3802/jgo.2023.34.e75)pISSN 2005-0380·eISSN 2005-0399  \nOriginal Article  \nReceived: Nov 28, 2022  \nRevised: May 15, 2023  \nAccepted: Jun 22, 2023  \nPublished online: Jul 7, 2023  \nCorrespondence to  \nConstantijne H. Mom  \nDepartment of Gynecological Oncology, Amsterdam University Medical Center, PO box 22660, 1100 DD Amsterdam Zuidoost, The Netherlands.  \nEmail: [c.mom@amsterdamumc.nl](c.mom@amsterdamumc.nl)  \n© 2023. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([https://](https://)[ ](https://)[creativecommons.org/licenses/by-nc/4.0/](creativecommons.org/licenses/by-nc/4.0/)) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nORCID iDs  \nLaure Nicolai  [https://orcid.org/0000-0003-3705-7900](https://orcid.org/0000-0003-3705-7900)[ ](https://orcid.org/0000-0003-3705-7900)Refika Yigit  [https://orcid.org/0000-0001-7379-2203](https://orcid.org/0000-0001-7379-2203)[ ](https://orcid.org/0000-0001-7379-2203)Maaike C.G. Bleeker  [https://orcid.org/0000-0001-9610-8064](https://orcid.org/0000-0001-9610-8064)[ ](https://orcid.org/0000-0001-9610-8064)Joost Bart  [https://orcid.org/0000-0002-0985-071X](https://orcid.org/0000-0002-0985-071X)[ ](https://orcid.org/0000-0002-0985-071X)Jacobus van der Velden  [https://orcid.org/0000-0002-5985-1163](https://orcid.org/0000-0002-5985-1163)  \nThe risk of lymph node metastasis in the new FIGO 2018 stage IA cervical cancer with >7 mm diameter  \nLaure Nicolai ,1 Refika Yigit ,2 Maaike C.G. Bleeker ,3 Joost Bart ,4 Jacobus van der Velden ,1 Constantijne H. Mom  1  \n1Amsterdam UMC location University of Amsterdam, Center for Gynecological Oncology, Amsterdam, The Netherlands  \n2University of Groningen, University Medical Center Groningen, Department of Gynecological Oncology, University Medical Center Groningen, Groningen, The Netherlands  \n3Amsterdam UMC location University of Amsterdam, Gynecological Pathology, Amsterdam, The Netherlands  \n4University of Groningen, University Medical Center Groningen, Department of Pathology, University Medical Center Groningen, Groningen, The Netherlands  \nABSTRACT  \nObjective: In the 2018 FIGO staging system, cervical cancers with ≤5 mm depth of invasion (DOI) and a diameter of >7 mm, first classified as stage IB, are classified as stage IA. In this group, it is unclear what the risk of lymph node metastasis (LNM) is. This retrospective cohort study aims to determine the incidence of LNM and to study the association between disease-related characteristics and LNM.  \nMethods: Women diagnosed with FIGO 2009 IB cervical cancer, with ≤5 mm DOI and a diameter >7 mm, treated with a radical hysterectomy and pelvic lymphadenectomy between 1985 and 2020 were selected from the databases ofthe Amsterdam University Medical Center and the University Medical Center Groningen. The specimens of patients with LNM were revised by expert pathologists. The incidence of LNM was calculated. The associations between LNM and DOI, diameter, histological type, clinical visibility and lymphovascular space invasion (LVSI) were evaluated by calculating odds ratios using logistic regression. Results: Of the 389 patients included, 10 had pathologically confirmed LNM (2.6%, 95% confidence interval=1.3%–4.5%). In case of LVSI, univariate analysis showed an increased risk of LNM (p=0.003 and p=0.012, respectively) . No difference in LNM was found between lesions diagnosed by microscopy and clinically visible lesions. No LNM were found inpatients without LVSI and a DOI of ≤3 mm.  \nConclusion: For patients with stage IA cervical cancer with a diameter >7 mm, we recommend consider","cbCaiu4VvgDzezxd","https://ap.wps.com/l/cbCaiu4VvgDzezxd","pdf",2267042,11,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n## FIGO staging update and rationale","[{\"question\":\"What patient group was analyzed in this study?\",\"answer\":\"Women with cervical cancer classified as FIGO 2018 stage IA defined by ≤5 mm depth of invasion (DOI) and tumor diameter \\u003e7 mm.\"},{\"question\":\"How often did lymph node metastasis occur?\",\"answer\":\"Among 389 included patients, 10 had pathologically confirmed LNM, for an incidence of 2.6% (95% CI 1.3%–4.5%).\"},{\"question\":\"Which factors were associated with lymph node metastasis?\",\"answer\":\"LNM risk increased with lymphovascular space invasion (LVSI) in univariate analysis, while no difference in LNM was found between microscopy-diagnosed lesions and clinically visible lesions.\"}]","The risk of lymph node metastasis in the new FIGO 2018 stage IA cervical cancer with >7 mm diameter - Original Article | PDF",1790240891,28]