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Methods: retrospective collection and analysis of 8340 hospitalized thyroid cancer cases from January 2018 to December 2020; χ2 test, rank-sum test, and multiple logistic regression were used. A nomogram prediction model was built and validated with receiver operating characteristic, calibration curves, and decision-curve analysis. Results: 3.6% developed temporary VCP; multiple factors and independent risks were identified. Conclusion: higher T stage, multifocal carcinoma, and prolonged surgery time may independently increase transient VCP risk.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-risk-factors-for-postoperative-temporary-vocal-cord-paralysis-after-thyroid-cancer-surgery-an-observational-retrospective-cohort-study/331156/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-risk-factors-for-postoperative-temporary-vocal-cord-paralysis-after-thyroid-cancer-surgery-an-observational-retrospective-cohort-study/331156.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study objective regarding vocal cord paralysis after thyroid cancer surgery?","Question",{"text":112,"@type":113},"The study analyzes potential factors influencing new-onset postoperative transient vocal cord paralysis (VCP) in thyroid cancer patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the data and factors analyzed in this retrospective cohort study?",{"text":117,"@type":113},"Case information of 8340 thyroid cancer patients hospitalized from January 2018 to December 2020 was collected retrospectively. Factors were tested with a χ2 test and rank-sum test, and independent risks were assessed using multiple logistic regression.",{"name":119,"@type":110,"acceptedAnswer":120},"Which factors were identified as independent risk factors for postoperative transient VCP?",{"text":121,"@type":113},"Independent risk factors were T stage (OR 1.411), multifocal carcinoma (OR 1.532), and duration of surgery (OR 1.009).",{"name":123,"@type":110,"acceptedAnswer":124},"How was the clinical prediction model constructed and validated?",{"text":125,"@type":113},"A nomogram was used to construct the clinical prediction model, validated in the validation set using receiver operating characteristic, calibration curves, and decision-curve analysis.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},331156,1790179374,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","’Retrospective Cohort Study  \nThe risk factors for postoperative temporary vocal cord paralysis after thyroid cancer surgery: an observational retrospective cohort study  \nYujia Han, MSca , Yishen Zhao, PhDa , Jiedong Kou, MSca , Jingting Li, PhDa , Fang Li, PhDa , Rui Du, PhDa , Gianlorenzo Dionigi, PhDb , Francesco Frattini, PhDb , Nan Liang, PhDa,* , Hui Sun, PhDa,*  \nObjective: To analyze the potential factors influencing new-onset postoperative transient vocal cord paralysis (VCP) in thyroid cancer patients.  \nMethods: Case information of 8340 thyroid cancer patients hospitalized at China-Japan Union Hospital of Jilin University, Jilin Province, China, in the Thyroid Surgery Department from January 2018 to December 2020 was collected retrospectively and analyzed. The possible influencing factors were analyzed using a χ2 test, rank-sum test, and multiple logistic regression analysis. Anomogram was used to construct the clinical prediction model that was validated in the validation set by receiver operating characteristic, calibration curves, and Decision curve analysis.  \nResults: The strengthening the reporting of cohort, cross-sectional, and case–control studies in surgery (STROCSS) guideline was followed to conduct a retrospective cohort study. A total of 8340 patients, including 1817 (21 .8%) men and 6523 (78 .2%) women, were enrolled in this study. The rate of temporary VCP was 3 .6%(308/8340) . Based on the results of postoperative laryngoscopy, the patients were divided into VCP group and non-VCP group. Comparative analysis between the groups revealed that potential factors associated with postoperative transient VCP were tumor location on the dorsal side of the gland (P = 0.042), ultrasound showing a maximum nodal diameter > 1cm (P = 0.002), multifocal carcinoma (P \u003C 0.001), invasion of surrounding tissue (P = 0.005), lymph node metastases in the central compartment (P = 0.034), lateral cervical lymph node metastasis (P \u003C 0.001), and prolonged operation (P \u003C 0.001) . A multiple logistic regression analysis showed that the independent risk factors in postoperative transient VCP were T stage (OR = 1.411, P = 0.013, 95% CI: 1 .075–1.853), multifocal carcinoma (OR = 1.532, P = 0.013, 95% CI: 1 .095–2. 144), and duration of surgery (OR = 1.009, P \u003C 0.001, 95% CI: 1 .006–1.012) . Finally, a clinical prediction model was established via anomogram and was validated in the validation set, although its diagnostic efficacy needs to be improved further.  \nConclusion: HighT stage, multifocal carcinoma, and prolonged operation time may be independent risk factors for the occurrence of postoperative transient VCP in patients undergoing initial surgery for thyroid cancer.  \nKeywords cancer, influencing factors, thyroid surgery, vocal cord paralysis  \nIntroduction  \nDe novo vocal cord paralysis (VCP) is a common complication after thyroid surgery and is associated with increased morbidity, mortality, prolonged hospitalization, and high costs[1–4] . It leads to impaired vocal cord function and atrophy, often manifested by symptoms such as altered speech, difficulty in pronunciation and swallowing, and shortness of breath[1] . Injury to recurrent laryngeal  \nnerve (RLN) is a common cause of postoperative VCP, especially inpatients who have undergone surgery for malignant thyroid tumors[2–4]. According to the literature, the incidence rate of permanent RLN injury is 0.5%[5], while temporary RLN injury is 3%[6] . Temporary VCP occurs at a high rate of 2–13% within 2 weeks of thyroid surgery[7]. The factors influencing VCP after thyroid surgery are yet to be identified, requiring a large amount of data for evidence-based medicine. However, most of the  \naDivision of Thyroid Surgery, The China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun Cit","cbCairx0Z9RwVXDR","https://ap.wps.com/l/cbCairx0Z9RwVXDR","pdf",501881,"English","# Objective\n# Methods\n# Results\n# Conclusion\n# Introduction","[{\"question\":\"What is the study objective regarding vocal cord paralysis after thyroid cancer surgery?\",\"answer\":\"The study analyzes potential factors influencing new-onset postoperative transient vocal cord paralysis (VCP) in thyroid cancer patients.\"},{\"question\":\"How were the data and factors analyzed in this retrospective cohort study?\",\"answer\":\"Case information of 8340 thyroid cancer patients hospitalized from January 2018 to December 2020 was collected retrospectively. Factors were tested with a χ2 test and rank-sum test, and independent risks were assessed using multiple logistic regression.\"},{\"question\":\"Which factors were identified as independent risk factors for postoperative transient VCP?\",\"answer\":\"Independent risk factors were T stage (OR 1.411), multifocal carcinoma (OR 1.532), and duration of surgery (OR 1.009).\"},{\"question\":\"How was the clinical prediction model constructed and validated?\",\"answer\":\"A nomogram was used to construct the clinical prediction model, validated in the validation set using receiver operating characteristic, calibration curves, and decision-curve analysis.\"}]","The risk factors for postoperative temporary vocal cord paralysis after thyroid cancer surgery: an observational retrospective cohort study | PDF",1789991970,23]