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Methods: Immunohistochemical assessment of SALL4 and fascin was performed in 54 primary CRC adenocarcinoma cases. Results: SALL4 positivity appeared in 16.7% and moderate-to-high fascin in 38.9%. SALL4 correlated with lymphovascular invasion, while fascin associated with advanced pT stage, lymph node spread, and LVI, and both were linked. Conclusion: Findings suggest a potential interplay and marker potential, requiring further molecular study.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-relationship-between-sall4-and-fascin-expression-and-the-progression-of-colorectal-carcinoma-research-article/352079/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-relationship-between-sall4-and-fascin-expression-and-the-progression-of-colorectal-carcinoma-research-article/352079.png","ImageObject",300,407,{"name":92,"@type":93},"RuangKosong","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main objective of the study?","Question",{"text":112,"@type":113},"To evaluate the immunohistochemical expression of SALL4 and fascin in CRC cases and determine their relationship with clinicopathological parameters.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were SALL4 and fascin expression levels measured?",{"text":117,"@type":113},"SALL4 and fascin expression were assessed by immunohistochemistry on paraffin-embedded colectomy specimens using specific anti-fascin and anti-SALL4 antibodies, with scoring based on staining intensity and percentage of positive tumor cells.",{"name":119,"@type":110,"acceptedAnswer":120},"What associations were found between SALL4 and clinical features?",{"text":121,"@type":113},"SALL4 expression showed a significant positive relationship with lymphovascular invasion (LVI). It was also significantly associated with moderate-to-high fascin expression.",{"name":123,"@type":110,"acceptedAnswer":124},"What clinical parameters were associated with fascin expression?",{"text":125,"@type":113},"Moderate-to-high fascin expression was significantly associated with advanced pathological tumor stage (pT), lymph node spread, and LVI.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},352079,1790190310,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148},962090883219,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","RESEARCH ARTICLE  \n\n| Editorial Proc | ess: Submission:07/16/2025 Acceptance:01/29/2026 Published:02/06/2026 |\n| --- | --- |\n\nThe Relationship between SALL4 and Fascin Expression and the Progression of Colorectal Carcinoma  \nAya M. El-Iraqi1, Nagwa M. Abdel-Rhaman2, Azza Kamal Taha2 *  \nAbstract  \nObjective: SALL4 (Spalt-like transcription factor 4) is a stem cell transcription factor that is reactivated in various tumor tissues and has a proven pro-metastatic role in colorectal cancer (CRC). However, the mechanism of its reactivation in CRC remains elusive. fascin is an actin-bundling protein linked to CRC progression. Independent of this activity, fascin regulates stemness and embryonic stem cell-related genes in some cancers. Data on the role offascin in regulating stem cell transcription factors in CRC are scarce, and the relationship between fascin and SALL4 expression in CRChas not been investigated. This study aims to evaluate the immunohistochemical expression of SALL4 and fascin in fifty-four CRC cases and their relationship with clinicopathological parameters. Methods: The expression ofSALL4 and Fascin determined using immunohistochemistry in 54 paraffin-embedded colectomy specimens from patients with primary colorectal adenocarcinoma. Result: SALL4-positive expression was detected in 9 cases (16.7%), while moderate-to-high fascin expression was found in 21 cases (38.9%) . A significant positive relationship was identified between SALL4 expression and lymphovascular invasion (LVI) (P = 0.033). Moderate-to-high fascin expression was significantly associated with advanced pathological tumor (pT) stage (P = 0.023), lymph node (LN) spread (P = 0.031), and LVI (P = 0.010). Furthermore, a significant association was observed between SALL4 positivity and moderate-tohigh fascin expression (P = 0.009). Conclusion: This is the first study to demonstrate a significant association between SALL4 and fascin expression in CRC patients, suggesting a potential interplay between them. Both proteins may represent potential markers of CRC progression. Molecular studies are required to further investigate the interaction between SALL4 and fascin in CRC.  \nKeywords: SALL4-Fascin-Colorectal cancer  \nAsian Pac J Cancer Prev, 27 (2), 637-642  \nIntroduction  \nColorectal cancer (CRC) is the third most frequent cancer and the second leading cause of malignancy-related death worldwide [1] . Strong evidence suggests that neoplasms originate and progress with the aid of cancer stem cells (CSCs), which exhibit features of normal stem cells, such as self-renewal and resistance to therapy. Investigating the mechanisms that regulate and maintain CSCs is, therefore, essential [2] .  \nSALL4, a transcription factor related to the SALL gene family, serves as a CSC marker in various tumors [3, 4] . It is highly expressed in the serum and tissues ofCRC, and its expression level correlates with lymph node spread [5] . However, the underlying mechanism ofSALL4 expression in CRC remains unclear [3] .  \nfascin is a 55 kDa actin-binding protein that stabilizes cell protrusions like filopodia. Its expression in neoplastic cells increases migration, infiltration, and lymph node spread [6]. Several actin-independent, pro-metastatic roles  \noffascin have also been reported. For example, fascin maintains or increases cancer stemness in melanoma and mammary CSCs independently of its actin-binding function [2, 7, 8] .  \nData on the role offascin in regulating transcription factors associated with pluripotency and self-renewal in CRC are limited. Moreover, the relationship between SALL4 and fascin in CRC has not been described. Therefore, this study aims to investigate the relationship between SALL4 and fascin expression in CRC and their association with clinicopathological features using immunohistochemistry.  \nMaterials and Methods  \nStudy design and setting  \nAcross-sectional retrospective study was conducted in the pathology laboratory of Al-Zahraa University Hospit","cbCaikqy90eP9REp","https://ap.wps.com/l/cbCaikqy90eP9REp","pdf",1195111,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Cancer stem cells and CRC\n## SALL4 in tumors\n## Fascin and CRC progression\n## Study rationale\n# Materials and Methods\n## Study design and setting\n## Study materials\n## Inclusion and Exclusion criteria\n## Methods\n## Immunohistochemistry\n## Evaluation of immunohistochemistry","[{\"question\":\"What was the main objective of the study?\",\"answer\":\"To evaluate the immunohistochemical expression of SALL4 and fascin in CRC cases and determine their relationship with clinicopathological parameters.\"},{\"question\":\"How were SALL4 and fascin expression levels measured?\",\"answer\":\"SALL4 and fascin expression were assessed by immunohistochemistry on paraffin-embedded colectomy specimens using specific anti-fascin and anti-SALL4 antibodies, with scoring based on staining intensity and percentage of positive tumor cells.\"},{\"question\":\"What associations were found between SALL4 and clinical features?\",\"answer\":\"SALL4 expression showed a significant positive relationship with lymphovascular invasion (LVI). It was also significantly associated with moderate-to-high fascin expression.\"},{\"question\":\"What clinical parameters were associated with fascin expression?\",\"answer\":\"Moderate-to-high fascin expression was significantly associated with advanced pathological tumor stage (pT), lymph node spread, and LVI.\"}]","The Relationship between SALL4 and Fascin Expression and the Progression of Colorectal Carcinoma - Research Article | PDF",1790097588,15]