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Searches across Scopus, Web of Science, PubMed, and Google Scholar identified 20 included studies. Women with ovarian cancer showed a significantly higher colorectal cancer incidence (SIR 1.69; 95% CI 1.39-1.98), including colon and rectal subtypes. Bidirectional risk was observed: ovarian cancer in women with colorectal cancer (SIR 1.48; 95% CI 1.17-1.79). Findings highlight the need for advanced genetic research and vigilant cancer surveillance.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-relationship-between-ovarian-and-colorectal-cancers-a-systematic-review-and-meta-analysis/371095/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-relationship-between-ovarian-and-colorectal-cancers-a-systematic-review-and-meta-analysis/371095.png","ImageObject",300,407,{"name":92,"@type":93},"anakgang17","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study’s primary aim regarding ovarian and colorectal cancers?","Question",{"text":113,"@type":114},"To examine the relationship between ovarian cancer and colorectal cancer, with a particular focus on the standardized incidence ratio (SIR).","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How many studies were included in the meta-analysis, and how were they selected?",{"text":118,"@type":114},"A comprehensive search across multiple databases (Scopus, Web of Science, PubMed, and Google Scholar) identified 20 studies for the final analysis.",{"name":120,"@type":111,"acceptedAnswer":121},"What did the results show about colorectal cancer risk in women with ovarian cancer?",{"text":122,"@type":114},"Women with ovarian cancer had a significantly higher incidence of colorectal cancer (SIR 1.69; 95% CI 1.39–1.98), including increased risk for both colon and rectal cancers.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},371095,1790309205,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962090883568,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Korean Journal of Clinical Oncology 2025;21:150-158 [https://doi.org/10.14216/kjco.25355](https://doi.org/10.14216/kjco.25355)  \n[pISSN 1738-8082](pISSN 1738-8082) ∙ eISSN 2288-4084  \nOriginal Article  \nThe relationship between ovarian and colorectal cancers: a systematic review and meta-analysis  \nHeba Ramadan  \nDepartment of Pharmacy, Agamy Medical District, Ministry of Health and Population, Alexandria, Egypt  \nPurpose: This systematic review and meta-analysis aimed to examine the relationship between ovarian and colorectal cancer, with a particular focus on the standardized incidence ratio (SIR).  \nMethods: A comprehensive search was conducted across multiple databases, including Scopus, Web of Science, PubMed, and Google Scholar. A total of 20 studies were included in the final analysis.  \nResults: The results indicated that women with ovarian cancer had a significantly higher incidence of colorectal cancer (SIR, 1.69; 95% confidence interval [CI], 1.39–1.98), with an increased risk for both colon (SIR, 1.57; 95% CI, 1.14–1.99) and rectal cancers (SIR, 1.58; 95% CI, 1.38–1.78). Subgroup analysis of borderline ovarian tumor revealed an SIR for colorectal cancer of 1.27 (95% CI, 0.99–1.55), with a significant risk in the serous subtype (SIR, 1.38; 95% CI, 1.09–1.67). Conversely, studies examining ovarian cancer in women diagnosed with colorectal cancer showed an SIR of 1.48 (95% CI, 1.17–1.79). Specifically, women with colon cancer had a higher incidence of ovarian cancer (SIR, 1.64; 95% CI, 1.25–2.03), while women with rectal cancer showed a decreased risk (SIR, 0.88; 95% CI, 0.77–0.99). The results underscore the potential bidirectional relationship between ovarian and colorectal cancers, which may be influenced by genetic predispositions. Conclusion: Future advanced genetic studies are needed to better understand the underlying molecular mechanisms. Additionally, the results emphasize the importance of careful cancer surveillance and early detection strategies for women with a history of either ovarian cancer or colorectal cancer.  \nKeywords: Colonic neoplasms, Colorectal neoplasms, Ovarian neoplasms, Rectal neoplasms, Standardized incidence ratio  \nINTRODUCTION  \nBackground and clinical relevance  \nOvarian and colorectal cancers are two of the most prevalent malignancies globally, representing significant public health burdens for women. Ovarian cancer is one of the leading causes of cancer-related mortality among women. Colorectal cancer, affecting both men and women, is the third most commonly diagnosed cancer and the second leading cause of cancer death globally [1,2]. While ovarian cancer and colorectal cancer (colon or rectal cancers) are often studied separately, there is emerging evidence suggesting a possible link between these two cancers, raising the ques-  \nReceived: Jun 13, 2025 Revised: Jul 18, 2025 Accepted: Aug 28, 2025  \nCorrespondence to: Heba Ramadan  \nDepartment of Pharmacy, Agamy Medical District, Ministry of Health and Population, Alexandria 21575, Egypt  \nTel: +20-3020899 Fax: +20-3020899  \nE-mail: [hebaramadan_24884@yahoo.com](hebaramadan_24884@yahoo.com)  \n© 2025 Korean Society of Surgical Oncology  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([http://creativecommons.org/licenses/by-nc/4.0](http://creativecommons.org/licenses/by-nc/4.0)) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \ntion of whether a genetic factor may predispose individuals to both types of malignancies [3]. In this context, terms such as secondary cancer and second primary malignancies are important to differentiate. Secondary cancer refers to malignancies that arise as a direct consequence of an earlier cancer, while second primary malignancies refer to new and distinct cancers that develop independently of the original malignancy. While secondary cancers are ","cbCaikkZIli3sJho","https://ap.wps.com/l/cbCaikkZIli3sJho","pdf",679767,"English","# Introduction\n## Background and clinical relevance\n## Knowledge gaps and rationale for the study\n# Purpose\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What was the study’s primary aim regarding ovarian and colorectal cancers?\",\"answer\":\"To examine the relationship between ovarian cancer and colorectal cancer, with a particular focus on the standardized incidence ratio (SIR).\"},{\"question\":\"How many studies were included in the meta-analysis, and how were they selected?\",\"answer\":\"A comprehensive search across multiple databases (Scopus, Web of Science, PubMed, and Google Scholar) identified 20 studies for the final analysis.\"},{\"question\":\"What did the results show about colorectal cancer risk in women with ovarian cancer?\",\"answer\":\"Women with ovarian cancer had a significantly higher incidence of colorectal cancer (SIR 1.69; 95% CI 1.39–1.98), including increased risk for both colon and rectal cancers.\"}]","The relationship between ovarian and colorectal cancers - a systematic review and meta-analysis | PDF",1790191232,23]