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This study examined SSIs among individuals with ovarian and uterine cancers and assessed how infections affected time to adjuvant treatment and subsequent oncologic outcomes. Patients treated surgically from 1 January 2015 to 30 September 2017 were analyzed using NSQIP data and chart review. Among 371 patients, time to therapy differed by modality, while SSI associations varied by cancer type.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-relation-between-post-operative-surgical-site-infection-and-time-to-start-adjuvant-treatment-in-ovarian-and-uterine-cancers/374737/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-relation-between-post-operative-surgical-site-infection-and-time-to-start-adjuvant-treatment-in-ovarian-and-uterine-cancers/374737.png","ImageObject",300,407,{"name":92,"@type":93},"Dipper","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main objective of this study?","Question",{"text":112,"@type":113},"To evaluate whether surgical site infections are associated with the time to start adjuvant treatment after surgery and how this relates to oncologic outcomes in ovarian and uterine cancers.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients selected for the analysis?",{"text":117,"@type":113},"Patients underwent surgery between 1 January 2015 and 30 September 2017 and were included using institutional NSQIP data and chart reviews.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find regarding SSIs and treatment delays?",{"text":121,"@type":113},"A statistically significant difference in time to start treatment was observed between chemotherapy versus radiotherapy and related groups, but no significant difference was seen in time to start treatment for patients with or without SSIs.",{"name":123,"@type":110,"acceptedAnswer":124},"What impact did SSIs have on recurrence and survival?",{"text":125,"@type":113},"In uterine cancer patients, SSIs were linked to higher recurrence risk and poorer overall survival, while no survival difference related to SSIs was found for ovarian cancer patients.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},374737,1790576403,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149},1374404997633,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Article  \nThe Relation Between Post-Operative Surgical Site Infection and Time to Start Adjuvant Treatment in Ovarian and Uterine Cancers  \nKarlijn M. C. Cornel 1, Julie My Van Nguyen 2, Lilian T. Gien 1,3, Allan Covens 1,3 and Danielle Vicus 1,3, *  \nReceived: 17 June 2025  \nRevised: 25 July 2025  \nAccepted: 3 August 2025  \nPublished: 21 August 2025  \nCitation: Cornel, K.M.C.; Nguyen, J.M.V.; Gien, L.T.; Covens, A.; Vicus, D. The Relation Between Post-Operative Surgical Site Infection and Time to Start Adjuvant Treatment in Ovarian and Uterine Cancers. Curr. Oncol. 2025, 32, 474. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/curroncol32080474](10.3390/curroncol32080474)  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Division of Gynecologic Oncology, University of Toronto, Toronto, ON M5G 1E2, Canada; [karlijncornel@gmail.com](karlijncornel@gmail.com) (K.M.C.C.); [lilian.gien@sunnybrook.ca](lilian.gien@sunnybrook.ca) (L.T.G.); [al.covens@sunnybrook.ca](al.covens@sunnybrook.ca) (A.C.)  \n2 Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Juravinski Hospital and Cancer Centre, McMaster University, Hamilton, ON L8S 4L8, Canada; [nguyenjmv@hhsc.ca](nguyenjmv@hhsc.ca)  \n3 Division of Gynecologic Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada  \n* Correspondence: [danielle.vicus@sunnybrook.ca](danielle.vicus@sunnybrook.ca); Tel.: +1-416-480-4378; Fax: +1-416-480-6002  \nSimple Summary  \nOvarian and uterine cancers are mainly treated with a combination of surgery followed by adjuvant chemotherapy treatment and/or radiation treatment. Post-surgical complications, including surgical site infection, might influence the time to start adjuvant treatment, with a possible impact on patients’ outcomes. In this study, we evaluated the time to start adjuvant treatment after surgery, comparing patients with a surgical site infection to those without. A statistically significant difference in time to start treatment was found between patients with ovarian and uterine cancer, as well as between the time to start chemotherapy treatment compared to radiation treatment. Although no difference was seen between patients with or without a surgical site infection. Patients with uterine cancer and a surgical site infections had a significantly higher rate of recurrent disease and a poorer overall survival compared to patients without a surgical site infection. No difference was seen for recurrence-free and overall survival in patients with ovarian cancer. Since surgery is a significant part of treatment in patients with gynecologic malignancies, it is crucial to further investigate the impact of surgical-related complications on adjuvant treatment and oncologic outcomes. With the goal of improving and evolving oncological care for patients with gynecologic malignancies.  \nAbstract  \nSurgical site infections (SSIs) occur in 10–15% of patients and are linked to up to 29% of delays in starting adjuvant treatment. This study assessed the association between SSIsin patients with ovarian and uterine cancer and their impact on time to adjuvant therapy and oncologic outcomes. Patients who underwent surgery from 1 January 2015 to 30 September 2017 were included, using institutional National Surgical Quality Improvement Program (NSQIP) data and chart reviews. Among 371 patients (median followup 4.1 years), 243 (65.5%) received adjuvant treatment. The median time to start was 39 days for chemotherapy, 61 days for radiotherapy, and 42 days for combined therapy (p \u003C 0.001) . Patients with ovarian cancer began treatment sooner than those with uterine cancer (39 vs. 52 days, p \u003C 0.001), b","cbCaigskOTXnLhQR","https://ap.wps.com/l/cbCaigskOTXnLhQR","pdf",1019742,14,"English","# Simple Summary\n# Abstract\n# Keywords\n# Introduction","[{\"question\":\"What is the main objective of this study?\",\"answer\":\"To evaluate whether surgical site infections are associated with the time to start adjuvant treatment after surgery and how this relates to oncologic outcomes in ovarian and uterine cancers.\"},{\"question\":\"How were patients selected for the analysis?\",\"answer\":\"Patients underwent surgery between 1 January 2015 and 30 September 2017 and were included using institutional NSQIP data and chart reviews.\"},{\"question\":\"What did the study find regarding SSIs and treatment delays?\",\"answer\":\"A statistically significant difference in time to start treatment was observed between chemotherapy versus radiotherapy and related groups, but no significant difference was seen in time to start treatment for patients with or without SSIs.\"},{\"question\":\"What impact did SSIs have on recurrence and survival?\",\"answer\":\"In uterine cancer patients, SSIs were linked to higher recurrence risk and poorer overall survival, while no survival difference related to SSIs was found for ovarian cancer patients.\"}]","The Relation Between Post-Operative Surgical Site Infection and Time to Start Adjuvant Treatment in Ovarian and Uterine Cancers | PDF",1790202294,35]