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The review addresses unresolved questions about screening-related benefits and harms across participant groups. It synthesizes evidence from eligible studies that assessed anxiety and related patient-reported psychological impacts, stratified by detection route and timing, and evaluates study quality using the Mixed Methods Appraisal Tool.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-psychological-impact-of-screen-detected-cancer-a-systematic-review/344653/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-psychological-impact-of-screen-detected-cancer-a-systematic-review/344653.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-24","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main question of this systematic review?","Question",{"text":112,"@type":113},"How the psychological impact of cancer diagnosed through screening compares with cancers diagnosed through other routes where symptoms or incidental findings are involved.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were studies selected and quality assessed?",{"text":117,"@type":113},"Eligible studies examining psychological outcomes of screen-detected cancer were identified via PubMed, Embase, and PsycINFO, then screened by two reviewers and assessed using the Mixed Methods Appraisal Tool.",{"name":119,"@type":110,"acceptedAnswer":120},"What do the findings suggest about psychological outcomes after screen-detected diagnosis?",{"text":121,"@type":113},"Screen-detected diagnoses were associated with small to moderate increases in short-term adverse psychological outcomes, but most route-comparison studies found no meaningful differences or only small effects.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},344653,1790292517,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","Psycho‐Oncology  \nThe Psychological Impact of Screen‐Detected Cancer: A Systematic Review  \nEmma Lidington1,2 | Divyadharshini Ragupathy2 | Ninian Schmeising‐Barnes1,2  | Amanda Dibden1 | Jo Waller1,2 | Laura Marlow1,2  \n1Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, London,  \nUK | 2School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK Correspondence: Emma Lidington ([e.lidington@qmul.ac.uk](e.lidington@qmul.ac.uk))  \nReceived: 24 July 2025 | Revised: 29 October 2025 | Accepted: 5 December 2025  \nKeywords: anxiety | cancer | early detection of cancer | mass screening | oncology | patient reported outcome measures | psychology  \nABSTRACT  \nBackground: The benefits and harms of cancer screening must be balanced for all participant groups, including those who goon to have cancer diagnosed. The psychological impact of having cancer diagnosed through screening, rather than via another route, is currently unclear.  \nAims: We conducted a systematic review to describe the psychological impact of detecting cancer through screening (screen‐ detected) compared to other routes (non‐screen‐detected) .  \nMethods: Eligible studies investigated the psychological impact of screen‐detected cancer. PubMed, Embase, and PsycINFO were searched. Two reviewers independently screened all titles, abstracts and full texts. We assessed quality using the Mixed Methods Appraisal Tool. Psychological outcome data were extracted for groups with screen‐detected and non‐screen‐detected cancers, calculating Cohen's d where relevant. Results were narratively synthesized.  \nResults: We included 33 papers presenting quantitative results from 31 studies. All were considered medium to high quality. Studies measured psychological outcomes across six cancer screening programmes (breast, prostate, colorectal, lung, cervical and ovarian) using 31 different outcome measures. Receiving a screen‐detected cancer diagnosis seemed to be associated with a small or moderate short‐term increase in adverse psychological outcomes. In studies comparing outcomes by detection route, most found no difference (n = 16 studies), or that patients with screen‐detected cancers fared better than those with non‐screen‐ detected cancers (n = 11 studies), but effect sizes were small.  \nConclusions: A screen‐detected cancer diagnosis can lead to short‐term adverse psychological outcomes; however, there is no strong evidence for a difference in psychological outcomes by detection route. Greater consistency of measures and timepoints would facilitate between‐study comparisons.  \nPROSPERO registration: PROSPERO 2017 CRD42017075269 .  \n1 | Introduction  \nFor most cancers, early‐stage diagnosis improves survival by increasing the chance of successful treatment [1, 2] . Screening  \nprovides an opportunity to detect cancer at an early stage by identifying individuals with cancer or a pre‐cancerous condition before symptoms occur [2, 3] . Evidence has shown that national screening programmes can reduce cancer‐specific mortality [4, 5] .  \n\n| The first two authors contributed equally to this article. |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.\u003Cbr>© 2026 The Author(s) . Psycho‐Oncology published by John Wiley & Sons Ltd. |\n\nPsycho‐Oncology, 2026; 35:e70358 1 of 32  \n[https://doi.org/10.1002/pon.70358](https://doi.org/10.1002/pon.70358)  \nCurrently, the UK has population‐based screening programmes for bowel, breast and cervical cancers, and a targeted programme for those at elevated risk of lung cancer [3] .  \nAs screening is offered to ‘healthy’ individuals, rather than those seeking help for symptoms, the benefits must outweigh any potential harms [6] . Screening can result in false negat","cbCainPTNx7VWdOj","https://ap.wps.com/l/cbCainPTNx7VWdOj","pdf",1457063,32,"English","# Introduction\n## Screening benefits and potential harms\n## Psychological benefits and adverse outcomes\n## Rationale for comparing detection routes\n# Abstract\n## Background and aims\n## Methods\n## Results\n## Conclusions","[{\"question\":\"What is the main question of this systematic review?\",\"answer\":\"How the psychological impact of cancer diagnosed through screening compares with cancers diagnosed through other routes where symptoms or incidental findings are involved.\"},{\"question\":\"How were studies selected and quality assessed?\",\"answer\":\"Eligible studies examining psychological outcomes of screen-detected cancer were identified via PubMed, Embase, and PsycINFO, then screened by two reviewers and assessed using the Mixed Methods Appraisal Tool.\"},{\"question\":\"What do the findings suggest about psychological outcomes after screen-detected diagnosis?\",\"answer\":\"Screen-detected diagnoses were associated with small to moderate increases in short-term adverse psychological outcomes, but most route-comparison studies found no meaningful differences or only small effects.\"}]","The Psychological Impact of Screen-Detected Cancer - A Systematic Review | PDF",1790054766,81]