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This study summarizes current clinical literature to assess whether Xihuang pill is safe and effective for various cancers, and to explore possible clinical dosage ranges and therapeutic effects. Searches across major Chinese and English databases identified 78 studies evaluating 3151 patients.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-prospect-of-xihuang-pill-in-the-treatment-of-cancers-research-article-abstract-methods-results-and-conclusion/405599/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-prospect-of-xihuang-pill-in-the-treatment-of-cancers-research-article-abstract-methods-results-and-conclusion/405599.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of the study on Xihuang pill?","Question",{"text":112,"@type":113},"To summarize current clinical literature and provide evidence on whether Xihuang pill is safe and effective for treating various cancers as Huoxuehuayu therapy.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were studies selected and analyzed?",{"text":117,"@type":113},"Publications on Xihuang pill and cancer were searched in seven Chinese and English databases (e.g., PubMed, CNKI, Google Scholar). Extracted data from inclusion-criteria studies were analyzed using SAS statistical software version 9.4.",{"name":119,"@type":110,"acceptedAnswer":120},"What overall therapeutic effects were reported for Xihuang pill?",{"text":121,"@type":113},"The therapeutic effects were mainly reflected in improving complete or partial response, reducing adverse reactions, improving quality of life, regulating immunity, alleviating pain, prolonging survival, reducing metastasis and recurrence, reducing inflammation, regulating estrogen levels, decreasing hypercoagulability, and reducing tumor markers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},405599,1790938652,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Heliyon 9 (2023) e15490  \nContents lists available at ScienceDirect  \nHeliyon  \njournal [homepage:](homepage: www.cell.com/heliyon)[ www.cell.com/heliyon](homepage: www.cell.com/heliyon)  \n| Research article\u003Cbr>The prospect of Xihuang pill in the treatment of cancers Zehui Chena, *, Zhiming Lib, Shuo Yanga, **, Yue Wei b, Jing An b\u003Cbr>a Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China b The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, 100029, China |  |  | |\n| --- | --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |  |\n| Keywords:\u003Cbr>Xihuang pill\u003Cbr>Safety and effectiveness Cancer\u003Cbr>Huoxuehuayu therapy Traditional Chinese medicine |  | Background: Xihuang pill, a Traditional Chinese Medicine (TCM) prescription and a representative of Huoxuehuayu therapy (one of the TCM therapies to promote blood circulation and remove blood stasis), has been widely used in breast cancer treatments. Although some evidence suggests the efficacy and safety of the Xihuang pill in treating certain cancer, the overall efficacy of the Xihuang pill in other cancer treatment is uncertain.\u003Cbr>Objective: This study aimed to summarize the current clinical literature and provided evidence support for addressing the research question of whether the Xihuang pill is safe and effective in the treatment of various cancers as Huoxuehuayu therapy, and possibly identify the clinical dosage range and therapeutic effect of Xihuang pills.\u003Cbr>Method: Seven Chinese and English databases such as PubMed, CNKI, and Google Scholar were searched to collect the publications on Xihuang pill and cancer. Then the researchers extracted data from the articles that met the inclusion criteria and used SAS statistical program version 9.4 (by SAS Institute, Cary, North Carolina, USA) for statistical statistics.\u003Cbr>Results: Our search identified 78 studies, including 69 RCTs (randomized control trials), 6 NRCCs (non-randomized concurrent control trials), and 3 BAS (before-after study), evaluating 3151 patients in total. The daily doses of Xihuang pills/capsule were between 2 g and 60 g, and duration between 2 weeks and 5 years, mostly used in the middle or late stage of cancer. The therapeutic effect of the Xihuang pill was mainly reflected in improving Complete Response (CR, a term from The Response Evaluation Criteria In Solid Tumors) or Partial Response (PR, a term from The Response Evaluation Criteria In Solid Tumors), reducing adverse reactions, promoting quality of life (QoL), regulating immunity, alleviating pain, prolonging survival, reducing metastasis and recurrence, reducing inflammation, regulating estrogen levels, decreasing hypercoagulative status, and reducing tumor markers.\u003Cbr>Conclusion: Xihuang pill representing Huoxuehuayu therapy has a good prospect in the treatment of cancer. |  |\n\n1. Introduction  \nCancer incidence and mortality are rapidly growing worldwide. In 2020, an estimated 19.3 million new cancer cases had been diagnosed worldwide, with around 10.0 million cancer deaths. In 2040, there will be an estimated 28.4 million cancer cases expected  \n* Corresponding author.  \n** Corresponding author.  \nE-mail addresses: [chenzh@mail.cintcm.ac.cn](chenzh@mail.cintcm.ac.cn) (Z. Chen), [y1y6y3@139.com](y1y6y3@139.com) (S. Yang).  \n[https://doi.org/10.1016/j.heliyon.2023.e15490](https://doi.org/10.1016/j.heliyon.2023.e15490)  \nReceived 18 November 2022; Received in revised form 1 April 2023; Accepted 12 April 2023 Available online 14 April 2023  \n2405-8440/© 2023 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license  \n([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)).  \nto happen globally [1]. Given its relapsing and fatal features, curing cancer seems to be insurmountable for the patients. Currently, common cancer therapeutics include surgery, chemotherapy, ","cbCaihNTkETqqB4F","https://ap.wps.com/l/cbCaihNTkETqqB4F","pdf",5383388,14,"English","# Introduction\n# Background\n# Objective\n# Method\n# Results\n# Conclusion","[{\"question\":\"What is the main purpose of the study on Xihuang pill?\",\"answer\":\"To summarize current clinical literature and provide evidence on whether Xihuang pill is safe and effective for treating various cancers as Huoxuehuayu therapy.\"},{\"question\":\"How were studies selected and analyzed?\",\"answer\":\"Publications on Xihuang pill and cancer were searched in seven Chinese and English databases (e.g., PubMed, CNKI, Google Scholar). Extracted data from inclusion-criteria studies were analyzed using SAS statistical software version 9.4.\"},{\"question\":\"What overall therapeutic effects were reported for Xihuang pill?\",\"answer\":\"The therapeutic effects were mainly reflected in improving complete or partial response, reducing adverse reactions, improving quality of life, regulating immunity, alleviating pain, prolonging survival, reducing metastasis and recurrence, reducing inflammation, regulating estrogen levels, decreasing hypercoagulability, and reducing tumor markers.\"}]","The prospect of Xihuang pill in the treatment of cancers - Research article - Abstract, methods, results, and conclusion | PDF",1790560891,35]