[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-375669-105":59,"doc-detail-375669-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-promise-of-piperine-in-cancer-chemoprevention","The Promise of Piperine in Cancer Chemoprevention","","Cancer is driven by uncontrolled growth and spread of malignant cells, forming a complex multistage disease shaped by biochemical and genetic alterations. Cancer chemoprevention uses pharmacologically active agents to block, suppress, prevent, or reverse invasive development, reducing impact on healthcare systems. Piperine, a nitrogen-containing alkaloid, is highlighted for antioxidant, anti-inflammatory, and immunomodulatory actions. The review details how piperine interferes with cancer molecular events and signaling pathways across stages, while also improving conventional therapies such as UV-phototherapy and TRAIL-based therapy, and addresses long-term safety, side effects, and the need for clinical trials.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-promise-of-piperine-in-cancer-chemoprevention/375669/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-promise-of-piperine-in-cancer-chemoprevention/375669.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does cancer chemoprevention play in managing cancer impact?","Question",{"text":112,"@type":113},"Cancer chemoprevention uses pharmacologically active agents to block, suppress, prevent, or reverse invasive cancer development, helping mitigate cancer’s impact on healthcare systems.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is piperine considered promising for cancer prevention and treatment?",{"text":117,"@type":113},"Piperine is a nitrogen-containing alkaloid with antioxidant, anti-inflammatory, and immunomodulatory effects, and it can inhibit cancer-related molecular processes and signaling pathways.",{"name":119,"@type":110,"acceptedAnswer":120},"How might piperine improve existing treatment approaches?",{"text":121,"@type":113},"The review discusses how piperine enhances the effectiveness of conventional treatments such as UV-phototherapy and TRAIL-based therapy, potentially creating synergistic cancer management strategies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},375669,1790694542,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","cancers   \nReview  \nThe Promise of Piperine in Cancer Chemoprevention  \nSalma Benayad 1, Hicham Wahnou 2, Riad El Kebbaj 1, Bertrand Liagre 3, Vincent Sol 3, Mounia Oudghiri 2, El Madani Saad 1, Raphaël Emmanuel Duval 4, * and Youness Limami 1,2, *  \nCitation: Benayad, S.; Wahnou, H.; El Kebbaj, R.; Liagre, B.; Sol, V.;  \nOudghiri, M.; Saad, E.M.; Duval, R.E.; Limami, Y. The Promise of Piperine in Cancer Chemoprevention. Cancers 2023, 15, 5488. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/cancers15225488](10.3390/cancers15225488)  \nAcademic Editor: Komal Raina  \nReceived: 13 October 2023  \nRevised: 14 November 2023  \nAccepted: 16 November 2023  \nPublished: 20 November 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University of Settat, Settat 26000, Morocco; [salmabenayad6@gmail.com](salmabenayad6@gmail.com) (S.B.); [elkebbajriad@gmail.com](elkebbajriad@gmail.com) (R.E.K.); [saad.elmadani@uhp.ac.ma](saad.elmadani@uhp.ac.ma) (E.M.S.)  \n2 Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, Casablanca 20100, Morocco; [hwwahnou@gmail.com](hwwahnou@gmail.com) (H.W.); [mounia.oudghiri@univh2c.ma](mounia.oudghiri@univh2c.ma) (M.O.)  \n3 Le Laboratoire des Agroressources, Biomol²cules et Chimie pour l'Innovation en Sant² (LABCiS), University Limoges, UR 22722, F-87000 Limoges, France; [bertrand.liagre@unilim.fr](bertrand.liagre@unilim.fr) (B.L.); [vincent.sol@unilim.fr](vincent.sol@unilim.fr) (V.S.)  \n4 The Franch Center for Scientific Research (CNRS), Universit² de Lorraine, L2CM, F-54000 Nancy, France  \n* Correspondence: [raphael.duval@univ-lorraine.fr](raphael.duval@univ-lorraine.fr) (R.E.D.); [youness.limami@uhp.ac.ma](youness.limami@uhp.ac.ma) (Y.L.)  \nSimple Summary: With 19.3 million new cancer cases worldwide and nearly 10.0 million cancerrelated deaths cancer is a global health challenge. Cancer is a disease caused by a variety of factors that lead to uncontrolled cell growth. Cancer chemoprevention using natural or synthetic compounds is a critical strategy to mitigate the impact of cancer on healthcare systems. One of the naturally occurring compounds, piperine, has shown potential in preventing cancer. Piperine is a nitrogen-containing alkaloid molecule with pleiotropic therapeutic effects, including antioxidant, anti-inflammatory, and immunomodulatory properties. With its various health benefits, piperine shows promise in inhibiting cancer-related molecular processes and enhancing existing treatments. This review explores piperine's potential in cancer prevention and treatment, suggesting it could be a valuable tool in managing cancer.  \nAbstract: Cancer, characterized by the unregulated growth and dissemination of malignantly transformed cells, presents a significant global health challenge. The multistage process of cancer development involves intricate biochemical and genetic alterations within target cells. Cancer chemoprevention has emerged as a vital strategy to address this complex issue to mitigate cancer's impact on healthcare systems. This approach leverages pharmacologically active agents to block, suppress, prevent, or reverse invasive cancer development. Among these agents, piperine, an active alkaloid with a wide range of therapeutic properties, including antioxidant, anti-inflammatory, and immunomodulatory effects, has garnered attention for its potential in cancer prevention and treatment. This comprehensive review explores piperine's multifaceted role in inhibiting the molecular events and signaling pathways associated with various sta","cbCairHlLSXc8nJX","https://ap.wps.com/l/cbCairHlLSXc8nJX","pdf",3326347,18,"English","# Introduction\n## Cancer as a global health challenge\n## Chemoprevention strategy and active agents\n## Piperine: therapeutic properties and rationale\n## Piperine mechanisms across stages of cancer\n## Synergy with conventional therapies\n## Safety considerations and need for clinical trials","[{\"question\":\"What role does cancer chemoprevention play in managing cancer impact?\",\"answer\":\"Cancer chemoprevention uses pharmacologically active agents to block, suppress, prevent, or reverse invasive cancer development, helping mitigate cancer’s impact on healthcare systems.\"},{\"question\":\"Why is piperine considered promising for cancer prevention and treatment?\",\"answer\":\"Piperine is a nitrogen-containing alkaloid with antioxidant, anti-inflammatory, and immunomodulatory effects, and it can inhibit cancer-related molecular processes and signaling pathways.\"},{\"question\":\"How might piperine improve existing treatment approaches?\",\"answer\":\"The review discusses how piperine enhances the effectiveness of conventional treatments such as UV-phototherapy and TRAIL-based therapy, potentially creating synergistic cancer management strategies.\"}]","The Promise of Piperine in Cancer Chemoprevention | PDF",1790215714,45]