[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-333663-105":59,"doc-detail-333663-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-progression-and-prospects-of-the-gene-expression-profiling-in-ovarian-epithelial-cancer-review-article","The Progression and Prospects of the Gene Expression Profiling in Ovarian Epithelial Cancer - Review Article","","Ovarian cancer is among the most common female cancers and carries high mortality worldwide, driven by complex, heterogeneous pathogenesis and progression. Understanding disease mechanisms is critical for enabling personalized therapy and improving outcomes. Gene expression profiling and the creation of gene signatures are highlighted as a route to targeted treatment across diverse histological and molecular ovarian cancer subtypes. However, gene signatures require logical clinical utility through rigorous validation to support appropriate treatment decisions and prognosis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-progression-and-prospects-of-the-gene-expression-profiling-in-ovarian-epithelial-cancer-review-article/333663/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-progression-and-prospects-of-the-gene-expression-profiling-in-ovarian-epithelial-cancer-review-article/333663.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is individualized therapy important in ovarian cancer?","Question",{"text":112,"@type":113},"Ovarian cancer shows complex heterogeneity and varied progression, making effective treatment challenging and increasing mortality. Personalized therapy depends on understanding pathogenesis and reliable prognostic tools.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role do gene expression profiling and gene signatures play?",{"text":117,"@type":113},"Gene expression profiling supports the development of gene signatures that can improve prognosis assessment, risk stratification, and survival prediction. Validated signatures can assist clinicians in selecting appropriate treatment lines.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is validation necessary for gene signatures?",{"text":121,"@type":113},"The document notes that clinical utility of gene signatures may not be logical unless validated. Validated signatures help ensure that research findings can be translated into dependable clinical practice.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333663,1791216069,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Gynecology and Minimally Invasive Therapy 13 (2024) 141-145  \n\n| Review Article |\n| --- |\n|  |\n\nThe Progression and Prospects of the Gene Expression Profiling  \nin Ovarian Epithelial Cancer  \nBanushree Chandrasekhar Srinivasamurthy1*, Subhashini Ramamoorthi2  \n1Department of Pathology, Indira Gandhi Medical College and Research Institute, 2Department of Pathology, JIPMER, Puducherry, India  \nAbstract  \nOvarian cancer is one of the most common cancers with a high mortality rate among females worldwide. The understanding of the pathogenesis of the disease is highly important to provide personalized therapy to the patients. Ovarian cancer is as heterogeneous as colon and breast cancer which makes it difficult to treat. The development of gene signature is the only hope in providing targeted therapy to improve the survival of ovarian cancer patients. Malignant epithelial carcinomas are the most common cancers ofthe ovary with different histological and molecular subtypes and clinical behavior. The development of precursor lesions of ovarian carcinoma in the tubes and endometrium has provided a new dimension to the origin of ovarian cancers. The clinical utility of various gene signatures may not be logical unless validated. Validated gene signatures can aid the clinician in deciding the appropriate line of treatment.  \nKeywords: Chemoresistance, gene signature, high-grade serous carcinoma, ovarian cancer, prognosis, validation  \nIntRoductIon  \nOvarian cancer is one of the most common cancers with a high mortality rate among females worldwide.[1,2] The incidence and mortality rate of ovarian cancer patients is increasing every year as the tumor is heterogeneous with complex pathogenesis and progression. This complexity has led to failure to effectively treat and prevent ovarian cancer.[3-5]Among ovarian cancer, malignant epithelial tumor constitutes around 95% and the other 5% is nonepithelial tumors. The high-grade serous carcinoma is the most common comprising around 70% of all ovarian cancers.[6,7] The advancement in the understanding of malignant epithelial tumor pathogenesis has led to Type I and Type II classification. The mucinous, low-grade serous, clear cell carcinomas are indolent with better survival chances, designated as Type I. The more aggressive tumors like high-grade serous, undifferentiated, and carcinosarcomas are designated as Type II.[8,9] A recent International Federation of Gynecology and Obstetrics (FIGO) staging system divides  \nArticle History:  \nSubmitted: 24-Jan-2023  \nRevised: 15-Sep-2023  \nAccepted: 22-Sep-2023  \nPublished: 18-Jul-2024  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code:\u003Cbr>| Website:\u003Cbr>[https://journals.lww.com/gmit](https://journals.lww.com/gmit) |\n|  | DOI:\u003Cbr>10.4103/gmit.gmit_ 13_23 |\n\novarian carcinoma into four stages with the integration of the fallopian tube and peritoneal involvement and recommends the institution of chemotherapy for high-grade tumor Stage Ic and Stage II–IV ovarian cancer.[10] The controversy persists regarding the benefits of chemotherapy as ovarian cancers are heterogeneous. The microarray gene signature analysis carried out on Stage I to Stage IV ovarian cancer has provided new prognostic indicators, risk stratification, and prediction of survival.[11] The gene expression profiling of ovarian cancer started as early as 2003, and large data sets are available to develop gene signatures. However, a prospective study is required to validate and translate the research data to clinical use.[12,13] The prognostic gene signature can bridge the gap between the average 5-year survival rate of early (90%) and advanced (10%–20%) ovarian cancer. [14,15] The early gene signature study was able to divide malignant epithelial  \nAddress for correspondence: Dr. Banushree Chandrasekhar Srinivasamurthy,  \nDepartment of Pathology, Indira Gandhi Medical College and Research Institute, Puducherry ‑ 605 009, India.  \nE‑mail: [drbanushree15@hotmail.com](drb","cbCaimXS3EJgE6P2","https://ap.wps.com/l/cbCaimXS3EJgE6P2","pdf",505192,"English","# Abstract\n# Introduction\n# Discussion","[{\"question\":\"Why is individualized therapy important in ovarian cancer?\",\"answer\":\"Ovarian cancer shows complex heterogeneity and varied progression, making effective treatment challenging and increasing mortality. Personalized therapy depends on understanding pathogenesis and reliable prognostic tools.\"},{\"question\":\"What role do gene expression profiling and gene signatures play?\",\"answer\":\"Gene expression profiling supports the development of gene signatures that can improve prognosis assessment, risk stratification, and survival prediction. Validated signatures can assist clinicians in selecting appropriate treatment lines.\"},{\"question\":\"Why is validation necessary for gene signatures?\",\"answer\":\"The document notes that clinical utility of gene signatures may not be logical unless validated. Validated signatures help ensure that research findings can be translated into dependable clinical practice.\"}]","The Progression and Prospects of the Gene Expression Profiling in Ovarian Epithelial Cancer - Review Article | PDF",1790003539,13]